Association between Depression and C-Reactive Protein
Open accessAbstract
Objective. Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism. The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP). Methods. Subjects consisted of 508 healthy adults (mean age 48.5 years; 49% women, 88% white) residing in central Massachusetts. Data were collected at baseline and at quarterly intervals over a one-year period per individual. Multivariable linear mixed models were used to assess the association for the entire sample and by gender. Results. The mean Beck Depression Inventory score was 5.8 (standard deviation (SD) 5.4; median 4.3), and average serum hs-CRP was 1.8 mg/L (SD 1.7; median 1.2). Results from the multivariable linear mixed models show that individuals with higher depression scores have higher levels of hs-CRP. Analyses by gender show persistence of an independent association among women, but not among men. Body mass index (BMI = weight(kg)/height(m)(2)) appears to be a partial mediator of this relationship. Conclusion. Depression score was correlated to hs-CRP levels in women. Further studies are required to elucidate the biological mechanisms underlying these associations and their implications.
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A longitudinal study found a positive association between BDI scores and serum hs-CRP levels only in women.
“A longitudinal study aimed at examining the association between depression and hs-CRP levels, found a positive association between BDI scores and serum hs-CRP levels only in women [90].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [90]
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References 27 · Cited by 61
- Authors
- Ma, Y., Chiriboga, D. E., Pagoto, S. L., Rosal, M. C., Li, W., Merriam, P. A., Hébert, J. R., Whited, M. C., & Ockene, I. S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- University of South Carolina (US)
- Corresponding author
- Ma, Yunsheng
- Venue
- Cardiology Research and Practice
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-8
- ISSN
- 2090-0597 (ISSN-L)
- PMC
- PMC3014664
- OpenAlex
- W2152071820
- Cited by
- 61
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 10 · 2012: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cardiology Research and Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion, cc-by)
- Scholar Commons (University of South Carolina) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (1R01 HL073194-01, 1 R21HL076796-01, 1 R21DK083700-01A1)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, C-reactive protein, high-sensitivity C-reactive protein, inflammation, cardiovascular risk, sex differences, body mass index, mediation, healthy adults
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