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MiR-146a in Immunity and Disease

Rusca, Nicole, Monticelli, Silvia·2011·Molecular Biology International
DOI 10.4061/2011/437301PMC PMC3200075
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Abstract

MicroRNAs (miRNAs) are regulatory molecules able to influence all aspects of the biology of a cell. They have been associated with diseases such as cancer, viral infections, and autoimmune diseases, and in recent years, they also emerged as important regulators of immune responses. MiR-146a in particular is rapidly gaining importance as a modulator of differentiation and function of cells of the innate as well as adaptive immunity. Given its importance in regulating key cellular functions, it is not surprising that miR-146a expression was also found dysregulated in different types of tumors. In this paper, we summarize recent progress in understanding the role of miR-146a in innate and adaptive immune responses, as well as in disease.

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Authors
Rusca, N., & Monticelli, S.
Affiliations
Institute for Research in Biomedicine, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
ORCID
Monticelli, Silvia
Venue
Molecular Biology International
Publisher
Wiley
Published
2011-04-07
Volume
2011
Pages
1-7
ISSN
2090-2190
DOI
10.4061/2011/437301
PMC
PMC3200075
Cited by
185
References
4
Language
en
Licence
creativecommons.org/licenses/by/3.0/ (unspecified)
Funders
  • Fundacja na rzecz Nauki Polskiej (TEAM/2009-4/2, D/09/42768, 229676)
  • German Academic Exchange Service (TEAM/2009-4/2, D/09/42768, 229676)
  • European Commission (TEAM/2009-4/2, D/09/42768, 229676)

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