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Cited by 29Neurological disorders and treatmentsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Striatal topographical organization: Bridging the gap between molecules, connectivity and behavior

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Basile, Gianpaolo Antonio, Bertino, Salvatore, Bramanti, Alessia, Ciurleo, Rosella, Anastasi, Giuseppe Pio, Milardi, Demetrio, Cacciola, Alberto·2021·European Journal of Histochemistry
DOI 10.4081/ejh.2021.3284PMC PMC8524362
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Abstract

The striatum represents the major hub of the basal ganglia, receiving projections from the entire cerebral cortex and it is assumed to play a key role in a wide array of complex behavioral tasks. Despite being extensively investigated during the last decades, the topographical organization of the striatum is not well understood yet. Ongoing efforts in neuroscience are focused on analyzing striatal anatomy at different spatial scales, to understand how structure relates to function and how derangements of this organization are involved in various neuropsychiatric diseases. While being subdivided at the macroscale level into dorsal and ventral divisions, at a mesoscale level the striatum represents an anatomical continuum sharing the same cellular makeup. At the same time, it is now increasingly ascertained that different striatal compartments show subtle histochemical differences, and their neurons exhibit peculiar patterns of gene expression, supporting functional diversity across the whole basal ganglia circuitry. Such diversity is further supported by afferent connections which are heterogenous both anatomically, as they originate from distributed cortical areas and subcortical structures, and biochemically, as they involve a variety of neurotransmitters. Specifically, the cortico-striatal projection system is topographically organized delineating a functional organization which is maintained throughout the basal ganglia, subserving motor, cognitive and affective behavioral functions. While such functional heterogeneity has been firstly conceptualized as a tripartite organization, with sharply defined limbic, associative and sensorimotor territories within the striatum, it has been proposed that such territories are more likely to fade into one another, delineating a gradient-like organization along medio-lateral and ventro-dorsal axes. However, the molecular and cellular underpinnings of such organization are less understood, and their relations to behavior remains an open question, especially in humans. In this review we aimed at summarizing the available knowledge on striatal organization, especially focusing on how it links structure to function and its alterations in neuropsychiatric diseases. We examined studies conducted on different species, covering a wide array of different methodologies: from tract-tracing and immunohistochemistry to neuroimaging and transcriptomic experiments, aimed at bridging the gap between macroscopic and molecular levels.

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  • The putamen receives topographically organized connections from various cortical regions, including the PMV and intraparietal areas, and the territories of innervation of these two regions show strong convergence.

    “As part of the dorsal striatum, the putamen receives topographically organized connections from various cortical regions (Cacciola et al. 2017; Milardi et al. 2019; Bertino et al. 2020; Quartarone et al. 2020; Basile et al. 2021), including the PMV and intraparietal areas; the territories of innervation of these two regions show strong convergence (Gerbella et al. 2016), in line with the”

    From Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition (2024) · cites this paper as Basile et al. 2021

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Authors
Basile, G. A., Bertino, S., Bramanti, A., Ciurleo, R., Anastasi, G. P., Milardi, D., & Cacciola, A.
Affiliations
  • University of Messina (IT)
  • University of Salerno (IT)
  • Centro Neurolesi Bonino Pulejo (IT)
Corresponding author
  • Basile, Gianpaolo Antonio
  • Bertino, Salvatore
  • Bramanti, Alessia
  • Ciurleo, Rosella
  • Anastasi, Giuseppe Pio
  • Milardi, Demetrio
  • Cacciola, Alberto
ORCID
Venue
European Journal of Histochemistry
Publisher
PAGEPress Publications
Published
2021-10-13
Volume
65
Issue
s1
ISSN
  • 1121-760X (ISSN-L)
  • 2038-8306
DOI
10.4081/ejh.2021.3284
PMC
PMC8524362
OpenAlex
W3207965988
Cited by
29
References
180
Citations by year
2026: 6 · 2025: 9 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 1
FWCI
0.45
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Histochemistry (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
striatum, topographic organization, basal ganglia, striatal gene expression, neurotransmitters, neuropsychiatric disorders, structure-function relationship, neural tracing, transcriptomics
MeSH terms
Animals, Cerebral Cortex, Corpus Striatum, Humans, Neural Pathways, Transcriptome, Connectome

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