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Cited by 21Fibromyalgia and Chronic Fatigue Syndrome ResearchMigraine and Headache StudiesBalance, Gait, and Falls Prevention

Relevance of lactate level detection in migrane and fibromyalgia

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Proia, Patrizia, Amato, Alessandra, Contrò, Valentina, Lo Monaco, Alessandra, Brusa, Jessica, Brighina, Filippo, Messina, Giuseppe·2019·European Journal of Translational Myology
DOI 10.4081/ejtm.2019.8202PMC PMC6615065
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Abstract

The aim of this study was to determine the blood lactate levels in healthy and pathological subjects, particularly with migraine and fibromyalgia. Moreover we investigated the possible correlation between lactate concentration, postural stability and balance disorders; the composition of the groups were: migraine (n = 25; age 49.7 ± 12.5), fibromyalgia (n = 10; age 43.7 ± 21.2), control group (n = 16 age 28.52 ± 2.4). The results showed that patients with fibromyalgia (FG) had higher lactate levels compared to migraine (MG) and control group (CG) (mean ± sd: FG = 1.78 ± 0.9 mmol/L; MG = 1.45±1 mmol/L; CG = 0,85 ± 0,07 mmol/L). The same situation was highlighted about the sway path length with eyes closed (FG = 518 ± 195 mm; MG = 465 ± 165 mm; CG = 405 ± 94,72 mm) and with eyes open (FG = 430 ± 220 mm; MG = 411 ± 143 mm; CG = 389 ± 107 mm). This can be explained by the fact that energy-intensive postural strategies must be used to optimize both static and dynamic coordination, in particular with repeated contractions of tonic oxidative muscle cells responsible for postural control.

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  • FM has been characterized by an increase in lactate levels, which appeared to facilitate the response of neuronal voltage-insensitive sodium channels.

    “FM has been characterized by an increase in lactate levels, which appeared to facilitate the response of neuronal voltage-insensitive sodium channels.15”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [15]

    The section labeled “Ethical Publication Statement” says fibromyalgia is characterized by increased lactate and that lactate appears to facilitate the response of ASICs, which it identifies as neuronal voltage-insensitive sodium channels. It qualifies that proposed effect as occurring together with ATP following exposure to low pH; the citing sentence omits those conditions. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Fibromyalgia patients exhibit reduced blood flow and degenerative changes in the muscles.

    “FM patients exhibit reduced blood flow and degenerative changes in the muscles, presumably due to local hypoxia, creating higher levels of free radicals that induce apoptosis, reduce ATP and increase lactate concentrations in muscle cells, leading to muscle weakness and pain.7,15”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [15]

    The References list a study of decreased muscle blood flow in fibromyalgia patients during standardized exercise, offering limited support for that part of the claim. But the paper’s background discussion reports another study finding no significant blood-flow difference, and its Discussion proposes hypervascularization in some muscles. No passage found describes degenerative changes in fibromyalgia patients’ muscles. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • The reduced blood flow and degenerative muscle changes in fibromyalgia are presumably due to local hypoxia, creating higher levels of free radicals that induce apoptosis, reduce ATP and increase lactate concentrations in muscle cells, leading to muscle weakness and pain.

    “FM patients exhibit reduced blood flow and degenerative changes in the muscles, presumably due to local hypoxia, creating higher levels of free radicals that induce apoptosis, reduce ATP and increase lactate concentrations in muscle cells, leading to muscle weakness and pain.7,15”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [15]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured

  • Motor control deficits in balance and postural control have been demonstrated in patients with FM.

    “Motor control deficits in balance and postural control have been demonstrated in patients with FM,8,15”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [15]

  • Aerobic or resistance training programs may be challenging for patients with FM due to poor movement confidence and competence and increased baseline lactate concentrations.

    “Aerobic or resistance training programs may be challenging for patients with FM due to poor movement confidence and competence17 and increased baseline lactate concentrations.15”

    From A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment (2025) · cites this paper as [15]

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Research works printed but not linked: 25

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Cited by

Sorted by citations

Authors
Proia, P., Amato, A., Contrò, V., Lo Monaco, A., Brusa, J., Brighina, F., & Messina, G.
Affiliations
University of Palermo (IT)
Corresponding author
  • Proia, Patrizia
  • Amato, Alessandra
  • Contrò, Valentina
  • Brusa, Jessica
  • Brighina, Filippo
  • Messina, Giuseppe
ORCID
Venue
European Journal of Translational Myology
Publisher
PAGEPress Publications
Published
2019-05-09
Volume
29
Issue
2
Pages
8202-8202
ISSN
  • 2037-7452 (ISSN-L)
  • 2037-7460
DOI
10.4081/ejtm.2019.8202
PMC
PMC6615065
OpenAlex
W2944610545
Cited by
21
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 2
FWCI
3.39
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Translational Myology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords
blood lactate, migraine, fibromyalgia, postural stability, balance disorders, postural control, energy metabolism

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