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Cited by 172Viral gastroenteritis research and epidemiologyParasitic Infections and DiagnosticsSalmonella and Campylobacter epidemiology

Prevalence of Gastrointestinal Pathogens in Developed and Developing Countries: Systematic Review and Meta-Analysis

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Fletcher, Stephanie M., McLaws, Mary-Louise, Ellis, John T.·2013·Journal of Public Health Research
DOI 10.4081/jphr.2013.e9PMC PMC4140330
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Abstract

Diarrhoeal illness is a leading cause of child mortality and morbidity worldwide. There are no precise or current estimates of the types and prevalence of pathogens associated with diarrheal illnesses in developed and developing settings. This systematic review assessed data from 60 studies published in the English language from five developing regions and developed countries worldwide to provide regional estimates of enteric pathogens affecting children. The random-effect method was used to establish the weighted average prevalence of pathogens in adults and children for each region. Significantly more pathogens were reported by studies from developing regions compared with Organisation for Economic Co-operation and Development countries (P<0.016). The identification rates of pathogens from community based and hospital based studies were similar (58.5% and 58.1% respectively, P<0.619). The overall detection of enteric pathogens in developing countries was higher in adults (74.8%; 95% CI 63.1-83.8%) compared with children (56.7%; 95% CI 53.0-60.4%) (P<0.001). Rotavirus was the most frequently detected pathogen in all regions with the highest rate, 24.8% (95% CI 18.0-33.1%), detected in the developed countries. This systematic review is the first to provide an estimate of the prevalence of enteric pathogens associated with diarrhoeal illnesses in adults and children in developed and developing settings. While pathogen detection rate is greater in developing regions the consistently high prevalence of rotavirus in both developed and developing settings underscores the urgent need for access to rotavirus vaccines. Increased travel between developing and developed countries increases disease risk, and hence developed countries have a vested interest in supporting vaccine accessibility in developing settings.

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Cited by

Sorted by citations

Authors
Fletcher, S. M., McLaws, M.-L., & Ellis, J. T.
Affiliations
University of Technology Sydney (AU)
Corresponding author
Fletcher, Stephanie M.
ORCID
Venue
Journal of Public Health Research
Publisher
SAGE Publications
Published
2013-03
Volume
2
Issue
1
Pages
42-53
ISSN
2279-9036 (ISSN-L)
DOI
10.4081/jphr.2013.e9
PMC
PMC4140330
OpenAlex
W1995269116
Cited by
172
References
2
Citations by year
2026: 8 · 2025: 10 · 2024: 22 · 2023: 11 · 2022: 18 · 2021: 23 · 2020: 22 · 2019: 22 · 2018: 11 · 2017: 10 · 2016: 6 · 2015: 7 · 2014: 1
FWCI
0.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Public Health Research (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Journal of Public Health Research (submittedVersion)
  • OPUS - Open Publications of UTS Scholars (University of Technology Sydney) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
enteric pathogens, diarrheal disease, rotavirus, pathogen prevalence, children, adults, developing countries, developed countries, rotavirus vaccination, pathogen detection rate

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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