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Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial

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Seyed Mansoor Rayegani, Seyed Ahmad Raeissadat, Morteza Sanei Taheri, Marzieh Babaee, Mohammad Hassan Bahrami, Dariush Eliaspour, Elham Ghorbani·2014·Orthopedic Review
DOI 10.4081/or.2014.5405PMC PMC4195987
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Abstract

We designed a randomized clinical trial with control group, to investigate the effects of platelet rich plasma (PRP) on pain, stiffness, function and quality of life in patients with knee osteoarthritis. Patients were randomly divided in two groups. For both groups of participants, therapeutic exercise was prescribed. In the PRP group, two courses of leukocyte rich PRP (5.6 fold higher platelet concentration) with a 4-week interval was injected. For each participant, Western Ontario and McMaster University's Arthritis Index (WOMAC) and the SF-36 questionnaire (Farsi version) were filled at the baseline and 6 months after treatments. Thirty-one patients in the PRP group and 31 patients in the control group were studied. Mean changes of total WOMAC, physical component summery and mental component summery of Short Form-36 in PRP group showed better improvement than control group (P<0.05). This study showed that intra articular PRP knee injection combined with therapeutic exercise can be more effective in pain reduction and improvement of stiffness and quality of life, compared with therapeutic exercise alone.

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  • In patients with knee osteoarthritis (KL grade 1-4), PRP resulted in a VAS change of Δ-53.9% compared to exercise only.

    “WOMAC: PRP Δ-55.3%; VAS: Δ-53.9%.”

    From Management of platelet-rich plasma and stem cells versus conventional treatments in musculoskeletal injury repair: A systematic review (2025) · cites this paper as [28]

    The Methods and Results report WOMAC and SF-36 measurements, and the Discussion says pain reduction was greater with PRP plus exercise than in the control group. They do not report a VAS outcome or a −53.9% VAS change; the cited sentence’s −55.3% WOMAC figure is also not established by these passages. The Methods identify the comparator as exercise with as-needed acetaminophen, rather than exercise only. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • In patients with knee osteoarthritis (KL grade 1-4), PRP resulted in a WOMAC change of Δ-55.3% compared to exercise only.

    “WOMAC: PRP Δ-55.3%; VAS: Δ-53.9%.”

    From Management of platelet-rich plasma and stem cells versus conventional treatments in musculoskeletal injury repair: A systematic review (2025) · cites this paper as [28]

    The Materials and Methods include patients with Kellgren–Lawrence grades 1–4, and the Results report greater improvement in total WOMAC with PRP plus exercise than with exercise alone. The Results do not give a −55.3% WOMAC change. The paper reports WOMAC and SF-36 outcomes for its own trial, not the cited sentence’s −53.9% VAS change. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 29

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Metadata

Authors
Rayegani, S. M., Raeissadat, S. A., Taheri, M. S., Babaee, M., Bahrami, M. H., Eliaspour, D., & Ghorbani, E.
Affiliations
Shahid Beheshti University (IR)
ORCID
Venue
Orthopedic Review
Publisher
Open Medical Publishing
Published
2014-08-08
Volume
6
Issue
3
Pages
5405-5405
ISSN
2035-8164 (ISSN-L)
DOI
10.4081/or.2014.5405
PMC
PMC4195987
OpenAlex
W2064954118
Cited by
112
References
0
Citations by year
2026: 3 · 2025: 4 · 2024: 14 · 2023: 8 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 10 · 2018: 14 · 2017: 8 · 2016: 10 · 2015: 6 · 2014: 1
FWCI
10.60
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Orthopedic Reviews (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
Keywords
platelet-rich plasma, knee osteoarthritis, intra-articular injection, exercise therapy, analgesia, joint stiffness, functional improvement, quality of life, WOMAC, SF-36, leukocyte-rich PRP

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