Cited by 69Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

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Residual Symptoms in Depression: Prevalence and Impact

Nierenberg, Andrew A.·2015·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.13097tx1c

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Abstract

Article Abstract Residual symptoms are experienced by most patients being treated for depression, including those who have achieved remission. These symptoms prevent individuals from fully recovering and feeling truly "well." Often, symptoms that are related to deficits in positive affect (such as anhedonia, pessimism, and lack of motivation) persist after the other symptoms of depression (such as irritability, distress, and low mood) have resolved. Clinicians must assess patients for residual symptoms using rating scales (eg, the Patient Health Questionnaire, Clinical Positive Affect Scale) and adjust treatment to improve patients†sense of well-being and normalcy. From the Department of Psychiatry and the Depression Clinical Research Program, Harvard Medical School and Massachusetts General Hospital, Boston. This CME activity is expired. For more CME activities, visit cme.psychiatrist.com. Find more articles on this and other psychiatry and CNS topics: The Journal of Clinical Psychiatry The Primary Care Companion for CNS Disorders

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Authors: Nierenberg, A. A.
Affiliations: Harvard University (US)
Corresponding author: Nierenberg, Andrew A.
ORCID: Nierenberg, Andrew A.
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2015-11-25
Volume: 76
Issue: 11
Pages: e1480-e1480
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.13097tx1c
OpenAlex: W2190250750
Cited by: 66
References: 0
Citations by year: 2026: 8 · 2025: 18 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2
FWCI: 1.68
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords: residual symptoms, depression, remission, anhedonia, pessimism, lack of motivation, positive affect, Patient Health Questionnaire, treatment modification, well-being
MeSH terms: Affect, Major Depressive Disorder, Depressive Disorder, Major, Humans, Remission Induction, Prevalence, Apathy, Anhedonia

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Residual Symptoms in Depression: Prevalence and Impact

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