CoChat
Sign Up
Cited by 172Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesHistorical and Modern Theater Studies

The DOI matches its Crossref record.

The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder

McIntyre, Roger S., Best, Michael W., Bowie, Christopher R., Carmona, Nicole E., Cha, Danielle S., Lee, Yena, Subramaniapillai, Mehala, Mansur, Rodrigo B., Barry, Harry, Baune, Bernhard T., Culpepper, Larry, Fossati, Philippe, Greer, Tracy L., Harmer, Catherine, Klag, Esther, Lam, Raymond W., Wittchen, Hans-Ulrich, Harrison, John·2017·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.16m11329
Open this paper in CoChat — free account

Abstract

OBJECTIVE: To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). METHODS: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D). RESULTS: The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P < .001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received. CONCLUSIONS: The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02508493.

Overview

Integrity signals

Registry

Crossref · 10.4088/jcp.16m11329

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cited by

Sorted by citations

See all 172

Related

Metadata

Authors
McIntyre, R. S., Best, M. W., Bowie, C. R., Carmona, N. E., Cha, D. S., Lee, Y., Subramaniapillai, M., Mansur, R. B., Barry, H., Baune, B. T., Culpepper, L., Fossati, P., Greer, T. L., Harmer, C., Klag, E., Lam, R. W., Wittchen, H.-U., & Harrison, J.
Affiliations
  • University Health Network (CA)
  • Queen's University (CA)
  • Centre for Addiction and Mental Health (CA)
  • The University of Adelaide (AU)
  • Boston University (US)
  • Centre National de la Recherche Scientifique (FR)
  • The University of Texas Southwestern Medical Center (US)
  • Warneford Hospital (GB)
  • University of British Columbia (CA)
  • King's College London (GB)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2017-08-23
Volume
78
Issue
7
Pages
873-881
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.16m11329
OpenAlex
W2747517649
Cited by
172
References
0
Citations by year
2026: 21 · 2025: 20 · 2024: 17 · 2023: 22 · 2022: 26 · 2021: 16 · 2020: 15 · 2019: 16 · 2018: 15 · 2017: 4
FWCI
9.54
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
cognitive impairment, major depressive disorder, screening tool, computerized cognitive assessment, concurrent validity, Trail Making Test, Digit Symbol Substitution Test, functional disability
MeSH terms
Adolescent, Adult, Aged, Cognition Disorders, Major Depressive Disorder, Diagnosis, Computer-Assisted, Female, Humans, Male, Mass Screening, Middle Aged, Neuropsychological Tests, Psychometrics, Recurrence, Reference Values, Reproducibility of Results, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review