Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder

Rink, Lena; Braun, Cora; Bschor, Tom; Henssler, Jonathan; Franklin, Jeremy; Baethge, Christopher

doi:10.4088/jcp.17r11693

Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder

OBJECTIVE To evaluate the efficacy and tolerability of dose increase compared to dose continuation of the initially prescribed antidepressant in antidepressant treatment failure (ATF). DATA SOURCES We searched CENTRAL, PubMed, Embase, and PsycINFO using generic terms for depression, dose increase…