Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent

Fu, Dong-Jing; Ionescu, Dawn F.; Li, Xiang; Lane, Rosanne; Lim, Pilar; Sanacora, Gerard; Hough, David; Manji, Husseini; Drevets, Wayne C.; Canuso, Carla M.

doi:10.4088/jcp.19m13191

Esketamine Nasal Spray for Rapid Reduction of Major Depressive Disorder Symptoms in Patients Who Have Active Suicidal Ideation With Intent

OBJECTIVE To compare esketamine to placebo, each in addition to standard-of-care treatment, for rapidly reducing major depressive disorder symptoms, including suicidal ideation. METHODS This phase 3, double-blind, multicenter study (ASPIRE I), conducted between June 2017 and December 2018, enroll…