How Interpersonal Psychotherapy Changes the Brain: A Study of fMRI in Borderline Personality Disorder
Open accessAbstract
Background: Recent guidelines and systematic reviews suggest that disorder-specific psychotherapeutic interventions are the first choice in the treatment of borderline personality disorder (BPD). The aim of this study is to examine brain activity changes in BPD patients ( DSM-5 ) who received a revised BPD-adapted interpersonal psychotherapy (IPT-BPD-R) compared with patients on the waiting list. Methods: Forty-three patients with a BPD diagnosis ( DSM-5 ) were randomly assigned to IPT-BPD-R (n = 22 patients) or the waiting list with clinical management (n = 21 patients) for 10 months. Both groups were tested before and after treatment with the Social and Occupational Functioning Assessment Scale (SOFAS), the Clinical Global Impressions-Severity of Illness scale (CGI-S), the Borderline Personality Disorder Severity Index (BPDSI), the Barratt Impulsiveness Scale-version 11 (BIS-11), and the Autobiographical Interview. Both groups underwent pre- and posttreatment functional magnetic resonance imaging (fMRI) testing. The fMRI task consisted of the presentation of resolved and unresolved life events compared to a neutral condition. All structural and functional images were analyzed using Statistical Parametric Mapping 12 software, which interfaces with MATLAB. Clinical data were analyzed using analysis of variance for repeated measures. Patients were recruited between September 2017 and April 2019. Results: In clinical results, for the 4 rating scales, a significant between-subje…
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References 48 · Cited by 11
- Authors
- Bozzatello, P., Morese, R., Valentini, M. C., Rocca, P., & Bellino, S.
- Affiliations
- University of Turin (IT)
- Università della Svizzera italiana (CH)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2021-11-16
- Volume
- 83
- Issue
- 1
- ISSN
- 0160-6689 (ISSN-L)
- 1555-2101
- OpenAlex
- W4288072538
- Cited by
- 11
- References
- 48
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- borderline personality disorder, interpersonal psychotherapy, brain activity changes, temporoparietal junction, anterior cingulate cortex, mentalization, impulsivity, functional MRI, psychotherapy outcome, waitlist control, social and occupational functioning, autobiographical memory, autobiographical interviews, disease severity
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