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Impact of Major Depressive Disorder on Comorbidities: A Systematic Literature Review
Open accessAbstract
To summarize the breadth of data exploring the relationship between major depressive disorder (MDD) and both the incidence and the disease course of a range of comorbidities. The authors searched MEDLINE, Embase, PsycINFO, Cochrane Database of Systematic Reviews, and several prespecified congresses. Searches included terms related to MDD and several comorbidity categories, restricted to those published in the English language from 2005 onward. Eligibility criteria included observational studies within North America and Europe that examined the covariate-adjusted impact of MDD on the risk and/or severity of comorbidities. A total of 6,811 articles were initially identified for screening. : Two investigators extracted data and assessed study quality. < .05) associated with an increased incidence of dementia and Alzheimer's disease as well as cognitive decline in individuals with existing disease; increased incidence and worsening of cardiovascular disease/events (although mixed results were found for stroke); worsening of metabolic syndrome; increased incidence of diabetes, particularly among men, and worsening of existing diabetes; increased incidence of obesity, particularly among women; increased incidence and worsening of certain autoimmune diseases; increased incidence and severity of HIV/AIDS; and increased incidence of drug abuse and severity of both alcohol and drug abuse. The presence of MDD was identified as a risk factor for both the development and the worsening of a range of comorbidities. These results highlight the importance of addressing depression early in its course and the need for integrating mental and general health care.
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“The relationship between the onset of MDD and several diseases is complex and potentially bidirectional in nature. 44”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [44]
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Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2022) · doi:10.1176/appi.books.9780890425787 · Cited by 23,476
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Metadata
- Authors
- Arnaud, A. M., Brister, T. S., Duckworth, K., Foxworth, P., Fulwider, T., Suthoff, E. D., Werneburg, B., Aleksanderek, I., & Reinhart, M. L.
- Affiliations
- Sage Therapeutics (United States) (US)
- National Alliance on Mental Illness (US)
- Corresponding author
- Suthoff, Ellison D.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2022-10-19
- Volume
- 83
- Issue
- 6
- ISSN
- 0160-6689 (ISSN-L)
- 1555-2101
- OpenAlex
- W4306753808
- Cited by
- 149
- References
- 1
- Citations by year
- 2026: 42 · 2025: 54 · 2024: 39 · 2023: 13 · 2022: 1
- FWCI
- 25.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biogen
- Sage Therapeutics
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- major depressive disorder, comorbidities, dementia, Alzheimer's disease, cognitive decline, cardiovascular disease, stroke, metabolic syndrome, diabetes mellitus, obesity, autoimmune disease, HIV/AIDS, substance abuse, alcohol abuse, drug abuse, comorbidity risk factors
- MeSH terms
- Alzheimer Disease, Major Depressive Disorder, Female, Humans, Male, Comorbidity, Cognitive Dysfunction
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