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Clozapine and Associated Diabetes Mellitus
Abstract
BACKGROUND: Clozapine is an effective therapy for the treatment of refractory psychosis. Clozapine-associated adverse effects include sedation, weight gain, sialorrhea, palpitations, seizures, and hematologic changes such as agranulocytosis. METHOD: We present a four-case series in which clozapine use was associated with either a de novo onset or severe exacerbation of preexisting diabetes mellitus. RESULTS: The change in glycemic control was not significantly related to weight gain. Three of the patients have been able to continue on clozapine therapy and have experienced a reduction in psychotic symptoms. CONCLUSION: Patients with a family history of diabetes mellitus or with preexisting diabetes mellitus may need to have blood sugar monitored closely during initiation of clozapine treatment.
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Cited by
Antipsychotic-induced weight gain: a comprehensive research synthesis
Allison, D. B., Mentore, J. L., Heo, M., Chandler, L. P., Cappelleri, J. C., Infante, M. C., & Weiden, P. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1686 · Cited by 2,382
Association of Diabetes Mellitus With Use of Atypical Neuroleptics in the Treatment of Schizophrenia
Sernyak, M. J., Leslie, D. L., Alarcon, R. D., Losonczy, M. F., & Rosenheck, R. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.561 · Cited by 623
Metadata
- Authors
- Popli, A. P., Konicki, P. E., Jurjus, G. J., Fuller, M. A., & Jaskiw, G. E.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 1997-03-15
- Volume
- 58
- Issue
- 3
- Pages
- 108-111
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2039239004
- Cited by
- 185
- References
- 0
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clozapine and Associated Diabetes Mellitus. https://app.cochat.ai/papers/10.4088/jcp.v58n0304
- The paper
- Popli, A. P., Konicki, P. E., Jurjus, G. J., Fuller, M. A., & Jaskiw, G. E. (1997). Clozapine and Associated Diabetes Mellitus. The Journal of Clinical Psychiatry. https://doi.org/10.4088/jcp.v58n0304
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
