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Cited by 160Treatment of Major DepressionBipolar Disorder and TreatmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record.

Combining Serotonin Reuptake Inhibitors and Bupropion in Partial Responders to Antidepressant Monotherapy

Bodkin, J. Alexander, Lasser, Robert A., Wines, James D., Gardner, David M., Baldessarini, Ross J.·1997·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v58n0401
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Abstract

BACKGROUND: Many patients with affective illness show partial or otherwise unsatisfactory responses to standard treatments, encouraging trials of combinations of pharmacologically dissimilar antidepressants. METHOD: Records of consecutive outpatients with affective disorders only partially responsive to treatment with a serotonin reuptake inhibitor (SRI) or bupropion, alone, were reviewed for changes in specific symptoms and risks of adverse events when an SRI and bupropion were combined. RESULTS: Greater symptomatic improvement was found in 19 (70%) of 27 subjects during a mean +/- SD of 11 +/- 14 months of combined daily use of bupropion (243 +/- 99 mg) with an SRI (31 +/- 16 mg fluoxetine-equivalents) than with either agent alone. Adverse effect risks were similar to those associated with each monotherapy, with a > 10% incidence of sexual dysfunction (N = 11, 41%), insomnia (N = 6, 22%), anergy (N = 4, 15%), and tremor (N = 3, 11%) during combined therapy; there were no seizures. CONCLUSION: With conservative dosing and close monitoring, combinations of SRIs with bupropion in this uncontrolled clinical series appeared to be safe and often more effective than monotherapy.

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Metadata

Authors
Bodkin, J. A., Lasser, R. A., Wines, J. D., Gardner, D. M., & Baldessarini, R. J.
Affiliations
Harvard University (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
1997-04-15
Volume
58
Issue
4
Pages
137-145
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v58n0401
OpenAlex
W1982954842
Cited by
159
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 6
FWCI
7.60
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k05mh047370-25)
  • National Institute of Mental Health (P01MH031154, MH-31154, MH47370)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
serotonin reuptake inhibitors, bupropion, antidepressant combination therapy, antidepressant monotherapy, mood disorders, adverse drug reactions, sexual dysfunction, insomnia, anergia, tremor, seizure risk
MeSH terms
Adult, Aged, Ambulatory Care, Anxiety Disorders, Depressive Disorder, Drug Administration Schedule, Drug Therapy, Combination, Epilepsy, Female, Fluoxetine, Humans, Male, Middle Aged, 1-Naphthylamine, Panic Disorder, Bupropion, Fluvoxamine, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Dysthymic Disorder, Sertraline

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