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Cited by 121Treatment of Major DepressionDementia and Cognitive Impairment ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Paroxetine and Fluoxetine Effects On Mood and Cognitive Functions in Depressed Nondemented Elderly Patients

Cassano, Giovanni Battista, Puca, Francomichele, Scapicchio, Pier Luigi, Trabucchi, Marco, Italian Study Group on Depression in Elderly Patients·2002·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v63n0504
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Abstract

BACKGROUND: A large proportion of the elderly population complains of depressive symptoms. The ideal antidepressant for these patients, who often suffer from numerous concomitant diseases, should not worsen their cognitive functions and should be free of contraindications. METHOD: To assess the effects of 2 selective serotonin reuptake inhibitors on cognitive functions in elderly depressed patients (ICD-10 criteria), we conducted a double-blind, randomized, parallel-group, multicenter study comparing paroxetine (20-40 mg daily) and fluoxetine (20-60 mg daily) treatment for 1 year. Cognitive performance was evaluated by means of the Buschke Selective Reminding Test, the Blessed Information and Memory Test, the Clifton Assessment Schedule, the Cancellation Task Test, and the Wechsler Paired Word Test; the Hamilton Rating Scale for Depression (HAM-D) and the Clinical Anxiety Scale were administered to assess the course of depressive and anxiety symptoms, respectively. RESULTS: 242 patients were enrolled (mean +/- SD age = 75.4 +/- 6.6 years). During the study, no deterioration of cognition was observed; on the contrary, most of the tested cognitive functions improved. Good antidepressant efficacy was maintained for over 1 year with both drugs, based on the percentage of responders to treatment (patients achieving a HAM-D total score < 10; 60%). Both drugs showed a good tolerability and safety profile. CONCLUSION: The 2 antidepressants proved to be suitable for the long-term treatment of depression in the elderly and to be devoid of detrimental effects on the tested cognitive functions.

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Metadata

Authors
Cassano, G. B., Puca, F., Scapicchio, P. L., Trabucchi, M., & Italian Study Group on Depression in Elderly Patients
Affiliations
University of Pisa (IT)
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2002-05-15
Volume
63
Issue
5
Pages
396-402
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v63n0504
OpenAlex
W2046119291
Cited by
121
References
0
Citations by year
2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 9 · 2013: 7 · 2012: 8
FWCI
4.24
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
paroxetine, fluoxetine, selective serotonin reuptake inhibitors, geriatric depression, cognitive function, long-term antidepressant treatment, antidepressant efficacy, safety and tolerability, anxiety symptoms
MeSH terms
Affect, Age Factors, Aged, Ambulatory Care, Anxiety Disorders, Cognition, Depressive Disorder, Double-Blind Method, Female, Fluoxetine, Humans, Male, Psychiatric Status Rating Scales, Survival Analysis, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Paroxetine

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