A relapse in pedophilic sex offending and subsequent suicide attempt during luteinizing hormone-releasing hormone treatment
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Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.Sir: In 1998, Rösler and Witztum1 published the first systematic study of antihormonal treatment of paraphilias with luteinizing hormone-releasing hormone (LHRH) agonists. Since the publication of their promising results, there has been an increasing interest in this new form of treatment.2 Our recently published review3 in the Journal revealed that 118 patients did not relapse if they remained on LHRH treatment.
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There has been at least one case report of treatment failure and attempted suicide associated with GnRH use (Briken 2004).
“and there has been at least one case report of treatment failure and attempted suicide associated with GnRH use (Briken 2004).”
From Pharmacological interventions for those who have sexually offended or are at risk of offending (2015) · cites this paper as Briken 2004
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Cites
Poulin, J., Daoust, A.-M., Forest, G., Stip, E., & Godbout, R. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00346-8 · Cited by 160 · see citing works
Sleep loss and postpartum psychosis
Sharma, V., & Mazmanian, D. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00015.x · Cited by 150 · see citing works
Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia
Chemerinski, E., Ho, B.-C., Flaum, M., Arndt, S., Fleming, F., & Andreasen, N. C. (2002) · Comprehensive Psychiatry · doi:10.1053/comp.2002.34627 · Cited by 101 · see citing works
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- Rösler A, Witztum E. Treatment of men with paraphilia with a long-acting analogue of gonadotropin-releasing hormone. N Engl J Med 1998;338:416-422
- Fagan PJ, Wise TN, Schmidt CW Jr, et al. Pedophilia. JAMA 2002;288:2458-2465
- Briken P, Hill A, Berner W. Pharmacotherapy of paraphilias with long-acting agonists of luteinizing hormone-releasing hormone: a systematic review. J Clin Psychiatry 2003;64:890-897
- Rösler A, Witztum E. Pharmacotherapy of the paraphilias in the next millennium. Behav Sci Law 2000;18:43-56
- Briken P, Nika E, Berner W. Treatment of paraphilia with luteinizing hormone-releasing hormone agonists. J Sex Marital Ther 2001;27: 45-55 REFERENCES
- Cavallaro R, Cocchi F, Angelone SM, et al. Cabergoline treatment of risperidone-induced hyperprolactinemia: a pilot study. J Clin Psychiatry 2004;56:187-190
- Ling LH, Ahlskog JE, Munger TM, et al. Constrictive pericarditis and pleuropulmonary disease linked to ergot dopamine agonist therapy (cabergoline) for Parkinson's disease. Mayo Clin Proc 1999;74:371-375
- Danoff SK, Grasso ME, Terry PB, et al. Pleuropulmonary disease due to pergolide use for restless legs syndrome. Chest 2001;120:313-316
- Flowers CM, Racoosin JA, Lu SL, et al. The US Food and Drug Administration's registry of patients with pergolide-associated valvular heart disease. Mayo Clin Proc 2003;78:730-731
- Bankowski BJ, Zacur HA. Dopamine agonist therapy for hyperprolactinemia. Clin Obstet Gynecol 2003;46:349-362 REFERENCES
- Ling LH, Ahlskog JE, Munger TM, et al. Constrictive pericarditis and pleuropulmonary disease linked to ergot dopamine agonist therapy (cabergoline) for Parkinson's disease. Mayo Clin Proc 1999;74:371-375
- Rains CP, Bryson HM, Fitton A. Cabergoline: a review of its pharmacological properties and therapeutic potential in the treatment of hyperprolactinaemia and inhibition of lactation. Drugs 1995;49: 255-279
- Bhatt MH, Keenan SP, Fleetham JA, et al. Pleuropulmonary disease associated with dopamine agonist therapy. Ann Neurol 1991;30: 613-616
- Flowers CM, Racoosin JA, Lu SL, et al. The US Food and Drug Administration's registry of patients with pergolide-associated valvular heart disease. Mayo Clin Proc 2003;78:730-731
- Frans E, Dom R, Demedts M. Pleuropulmonary changes during treatment of Parkinson's disease with a long-acting ergot derivative, cabergoline. Eur Respir J 1992;5:263-265
- Fritsch PO, Ruiz-Maldonado R. Stevens-Johnson syndrome: toxic epidermal necrolysis. In: Freedberg IM, Eisen AZ, Wolff K, et al. Fitzpatrick's Dermatology in General Medicine, vol 1. 5th ed. New York, NY: McGraw Hill; 1999:644-653
- Fritsch PO, Sidoroff A. Drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. Am J Clin Dermatol 2000;1:349-360
- Ghislain PD, Roujeau JC. Treatment of severe drug reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis and hyper- sensitivity syndrome. Dermatol Online J 2002;8:5. Available at: http://dermatology.cdlib.org/DOJvol8num1/reviews/drugrxn/ ghislain.html. Accessed Aug 22, 2004
- Roujeau JC. Stevens-Johnson syndrome and toxic epidermal necrolysis are severity variants of the same disease which differs from erythema multiforme. J Dermatol 1997;24:726-729
- Labreze CL, Lamireau T, Chawki D, et al. Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome. Arch Dis Child 2000;83:347-353
- Warnock CA, Azadian AG. Cross-sensitivity between paroxetine and sertraline. Ann Pharmacother 2002;36:631-633
- Jan V, Toledano C, Machet L, et al. Stevens-Johnson syndrome after sertraline [letter]. Acta Derm Venereol 2000;42:287
- Bodokh I, Lacour JP, Rosenthal E, et al. Lyell syndrome or toxic epidermal necrolysis and Stevens-Johnson syndrome after fluoxetine [in French] [letter]. Thérapie 1992;47:411
- Vincent A, Douville M, Baruch P. Serum sickness induced by fluoxe- tine [letter]. Am J Psychiatry 1991;148:1602-1603
- Wolkenstein P, Arevuz J, Diehl JL. Toxic epidermal necrolysis after fluvoxamine [letter]. Lancet 1993;342:304-305
- Tripathi A, Greenburger PA. Bupropion hydrochloride induced serum sickness-like reaction. Ann Allergy Asthma Immunol 1999;83: 165-166
- Bagshaw SM, Cload B, Gilmour J, et al. Drug-induced rash with eosinophilia and systemic symptoms syndrome with bupropion administration. Ann Allergy Asthma Immunol 2003;90:572-575
- Warnock JK, Knesevich JW. Adverse cutaneous reactions to antide- pressants. Am J Psychiatry 1988;145:425-430
- Gutierrez MA, Stimmel GL, Aiso JY. Venlafaxine: a 2003 update. Clin Ther 2003;25:2138-2154
- Beauclaire L, Radoi-Andraous D, Chouinard G. Selective serotonin- noradrenaline reuptake inhibitors. In: Sadock BJ, Sadock VA, eds. Comprehensive Textbook of Psychiatry. 7th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2000:2427-2432
- Thase ME. Effects of venlafaxine on blood pressure: a meta-analysis of original data from 3744 depressed patients. J Clin Psychiatry 1998; 59:502-508
- Rudolph RL, Derivan AT. The safety and tolerability of venlafaxine hydrochloride: analysis of the clinical trials database. J Clin Psychopharmacol 1996;16:54S-61S
- Sidwell RU, Swift S, Yan C-L, et al. Treatment of toxic epidermal necrolysis with intravenous immunoglobulin. Int J Clin Pract 2003;57:643-645 REFERENCES
- West JL, Jenzen HH, Lester BK. The psychosis of sleep deprivation. Ann N Y Acad Sci 1962;96:66-70
- Olney RK. Mescaline. Tex Med 1972;7:80-82
- Harley-Mason J, Laird AH, Smythies JR. The metabolism of mescalin in the human: delayed clinical reactions to mescalin. Confin Neurol 1958;18:152-155
- Aghajanian GK, Marek GJ. Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Res Brain Res Rev 2000;31:302-312
- Gove WR. Sleep deprivation: a cause of psychotic disorganization. AJS 1970;75:782-799
- McGuire BE, Basten CJ, Ryan CJ, et al. Intensive care unit syndrome. Arch Intern Med 2000;160:906-909
- Wright JBD. Mania following sleep deprivation. Br J Psychiatry 1993;163:679-680
- Herz MI, Melville C. Relapse in schizophrenia. Am J Psychiatry 1980;137:801-805
- King D. Pathological and therapeutic consequences of sleep loss: a review. Dis Nerv Syst 1977;11:873-879
- Snyder F. Dynamic aspects of sleep disturbance in relation to mental illness. Biol Psychiatry 1969;1:119-130
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Self-citation
- Authors
- Briken, P., Hill, A., & Berner, W.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2004-10-15
- Volume
- 65
- Issue
- 10
- Pages
- 1429
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2079870043
- Cited by
- 18
- References
- 0
- Citations by year
- 2022: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- pedophilic disorder, sexual offending, relapse, suicide attempts, GnRH agonist
- MeSH terms
- Adolescent, Adult, Fantasy, Humans, Gonadotropin-Releasing Hormone, Male, Pedophilia, Risk Factors, Sex Offenses, Suicide, Attempted, Treatment Outcome, Secondary Prevention
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