Cited by 103Attention Deficit Hyperactivity DisorderBipolar Disorder and TreatmentSchizophrenia research and treatment

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Attention-Deficit/Hyperactivity Disorder in Adults With Bipolar Disorder or Major Depressive Disorder: Results From the International Mood Disorders Collaborative Project

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McIntyre, Roger S., Kennedy, Sidney H., Soczynska, Joanna K., Nguyen, Ha T. T., Bilkey, Timothy S., Woldeyohannes, Hanna O., Nathanson, Jay A., Joshi, Shikha, Cheng, Jenny S. H., Benson, Kathleen M., Muzina, David J.·2010·The Primary Care Companion to The Journal of Clinical Psychiatry

DOI 10.4088/pcc.09m00861gryPMC PMC2947541

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Abstract

OBJECTIVE: Relatively few studies have evaluated the clinical implications of lifetime attention-deficit/hyperactivity disorder (ADHD) in adults with bipolar disorder or major depressive disorder (MDD). Herein, we sought to determine the prevalence as well as the demographic and clinical correlates of lifetime ADHD in persons with a mood disorder. METHOD: The first 399 patients enrolled in the International Mood Disorders Collaborative Project (IMDCP) were evaluated for lifetime ADHD using the Mini-International Neuropsychiatric Interview-Plus (MINI-Plus) as the primary instrument to derive current and lifetime DSM-IV diagnoses. All analyses of variables of interest were conducted utilizing the MINI-Plus, the Adult ADHD Self-Report Scale-v1.1, and the Wender Utah Rating Scale-Short Form. The effect of ADHD on clinical presentation, course of illness variables, comorbidity, anamnesis, treatment, and outcome are reported. The IMDCP is a joint initiative of the Mood Disorders Psychopharmacology Unit at the University Health Network, University of Toronto, Toronto, Ontario, Canada, and the Cleveland Clinic Center for Mood Disorders Treatment and Research at Lutheran Hospital, Cleveland, Ohio. All data for this study were procured between January 2008 and January 2009. RESULTS: The percentages of subjects with MDD or bipolar disorder meeting the DSM-IV criteria for lifetime adult ADHD were 5.4% and 17.6% (P < .001), respectively. Lifetime comorbid ADHD in both mood disorder populations was associated with earlier age at illness onset (MDD, P = .049; bipolar disorder, P = .005), a higher number of psychiatric comorbidities (eg, MDD and current panic disorder with agoraphobia [P = .002]; bipolar disorder and social phobia [P = .012]), and decreased quality of life (MDD, P = .018). CONCLUSIONS: The overarching findings herein are that the adult ADHD phenotype is commonly reported by individuals with MDD or bipolar disorder and is associated with a greater illness burden and complexity.

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Method
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Background
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Background
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“Studies have found that the adult ADHD phenotype is commonly reported by individuals with BD (McIntyre et al., 2010) and that children with ADHD have a higher risk of being diagnosed with BD later in life (Wang et al.”
Background
The Age of Onset of Bipolar Disorders
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Bartoli, F., Callovini, T., Calabrese, A., Cioni, R. M., Riboldi, I., Crocamo, C., & Carrà, G. (2021) · Brain Sciences · doi:10.3390/brainsci12010038 · Cited by 12
“Three studies were conducted in Turkey [30,31,38], two in India [29,34], two in North America [32,33], and the others in different European countries, namely Italy [36,37], Spain [39], and Switzerland [35].”
BackgroundResultInfluential
Treatment Patterns Among Patients with Attention-Deficit/Hyperactivity Disorder and Comorbid Anxiety and/or Depression in the United States: A Retrospective Claims Analysis
Schein, J. R., Childress, A. C., Gagnon‐Sanschagrin, P., Maitland, J., Bedard, J., Cloutier, M., & Guérin, A. (2023) · Advances in Therapy · doi:10.1007/s12325-023-02458-5 · Cited by 12
The relationship between auditory evoked potentials and symptoms of attention-deficit/hyperactivity disorder in adult patients with major depressive disorder
Kim, J. S., Kim, D.-W., Kwon, Y., Lee, H.-Y., Kim, S., & Shim, S. H. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.06.008 · Cited by 12
Validity of the ADHD module of the Mini International Neuropsychiatric Interview PLUS for screening of adult ADHD in treatment seeking substance use disorder patients: ADHD screening with MINI-Plus
Palma-Álvarez, R. F., Barta, C., Carpentier, P. J., CARRUTHERS, S. J., Crunelle, C. L., Demetrovics, Z., Dom, G., Faraone, S. V., Franck, J., Johnson, B., et al. (2020) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2020.04.013 · Cited by 12
Helpful family climate moderates the relationship between perceived family support of ADHD symptoms and depression: a conditional process model
Pojanapotha, P., Boonnag, C., Siritikul, S., Chalanunt, S., Kuntawong, P., Wongpakaran, N., & Wongpakaran, T. (2021) · BMC Psychology · doi:10.1186/s40359-021-00615-5 · Cited by 10
“ADHD symptoms can affect learning and work efficiency and decrease the likelihood of achievement and happiness in many aspects of life [10– 12], including quality of life [13, 14].”
Background
Suicide mortality after discharge from inpatient care for bipolar disorder: A 14-year Swedish national registry study
Iliachenko, E. K., Ragazan, D. C., Eberhard, J., & Berge, J. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.05.008 · Cited by 11
Perceived Social Support on the Relationship Between ADD/ADHD and Both Anxious and Depressive Symptoms Among Canadian Adults
Connolly, R. D., Lamont, A., & Speed, D. (2022) · Journal of Attention Disorders · doi:10.1177/10870547221136227 · Cited by 12
“Individuals with comorbid ADHD and anxiety and/or depression experience a lower quality of life than those who have only anxiety or depression (McIntyre et al., 2010).”
Background
Social function of adult men with attention-deficit/hyperactivity disorder in the context of military service
Noh, G.-M., Lee, S. M., & Bahn, G. H. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s180806 · Cited by 10
“Individuals with comorbid ADHD and depression have high disease burden and lower self-reported quality of life, compared to those with major depressive disorder alone.(32) Lower prevalence of psychiatric comorbidities may be one of the main reasons explaining the higher proportions of employment among subjects in MS.”
Background
The Role of Self- and Informant-Reports on Symptoms and Impairments in the Clinical Evaluation of Adult ADHD
Guo, N., Fuermaier, A. B. M., Koerts, J., Mueller, B. W., Mette, C., Tucha, L., Scherbaum, N., & Tucha, O. M. (2021) · Sustainability · doi:10.3390/su13084564 · Cited by 10
Combined Methylphenidate and Selective Serotonin Reuptake Inhibitors in Adults With Attention-Deficit/Hyperactivity Disorder
Lee, D. Y., Kim, C., Shin, Y., & Park, R. W. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.38398 · Cited by 9
Suicidal and non-suicidal self-injurious behaviour in patients with bipolar disorder and comorbid attention deficit hyperactivity disorder after initiation of central stimulant treatment: a mirror-image study based on the LiSIE retrospective cohort
Öhlund, L., Ott, M., Lundqvist, R., Sandlund, M., Renberg, E. S., & Werneke, U. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320947502 · Cited by 10
Relationship between bipolar disorder and attention deficit hyperkinetic disorder: An exploratory study.
Jhanda, S., Malhotra, S., & Grover, S. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.05.015 · Cited by 8
fNIRS Classification of Adults With ADHD Enhanced by Feature Selection
Hong, M., Dong, S.-Y., McIntyre, R. S., Chiang, S., & Ho, R. (2024) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2024.3522121 · Cited by 7
Self-citation
Evaluation of clinical and suicidal behavior characteristics among urban, Turkish middle-age depressive patients with comorbid attention deficit hyperactivity disorder
Erdoğan, E., Delibaş, D. H., & Gülseren, Ş. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_448_18 · Cited by 7
“ADHD, the reasons for an early onset of depression have not been fully clarified.[18,36,37] When the literature is examined,”
Background
The Burden of Attention-Deficit/Hyperactivity Disorder Traits in Adult Patients with Major Depressive Disorder in Japan
Kato, M., Tsuda, H., Chen, Y., Tsuji, T., & Nishigaki, N. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s399915 · Cited by 6
“This finding is in agreement with previous research suggesting that when ADHD is comorbid with depression, individuals have a higher disease burden and a lower quality of life than those affected by MDD alone.(41) In addition, both MDD and ADHD have previously been associated with functional impairments at work,(42,43…”
Result
Comorbidity and patterns of familial aggregation in attention-deficit/hyperactivity disorder and bipolar disorder in a family study of affective and anxiety spectrum disorders
Walsh, R. F. L., Sheppard, B. K., Cui, L., Brown, C., Meter, A. V., & Merikangas, K. R. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.08.017 · Cited by 8
The role of comorbid depressive symptoms on long-range temporal correlations in resting EEG in adults with ADHD
Huang, J., Ahlers, E., Bogatsch, H., Böhme, P., Ethofer, T., Fallgatter, A. J., Gallinat, J., Hegerl, U., Heuser, I., Hoffmann, K., et al. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01452-2 · Cited by 6
“In selfevaluating assessments, depressed aADHD patients, when compared to patients had only ADHD, report a higher demand for previous mental health care [8], experience lower occupational functioning [9, 10] and perceive consequently lower quality of life [11].”
Background
Is binge eating a cognitive disorder? Results from the International Mood Disorders Collaborative Project
Lee, Y. L., Carmona, N. E., Shekotikhina, M., Subramaniapillai, M., Mansur, R. B., Cha, D. S., Lee, J.-H., Lee, J., Zhou, A. J., Dale, R. M., et al. (2018) · Annals of Clinical Psychiatry · doi:10.1177/154733251803000105 · Cited by 6
Self-citation
Prevalence of adult attention deficit hyperactivity disorder in patients with bipolar affective disorder: A 1-year hospital-based cross-sectional study
Pattanshetti, N., Patil, N., & Tekkalaki, B. (2016) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/2349-5006.196325 · Cited by 6
Managing ADHD in Adults with Common Comorbidities
Sobanski, E., Paslakis, G., Schredl, M., Daffner, S., & Alm, B. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-248-3_8 · Cited by 6
Comorbidity
Fountoulakis, K. N. (2014) · Springer eBooks · doi:10.1007/978-3-642-37216-2_10 · Cited by 3
Laminar compartmentalization of attention modulation in area V4 aligns with the demands of visual processing hierarchy in the cortex
Wang, X., Nandy, A. S., & Jadi, M. P. (2023) · Scientific Reports · doi:10.1038/s41598-023-46722-8 · Cited by 4
A potential diagnostic blood test for attention deficit hyperactivity disorder
Woodruff, D. B., El-Mallakh, R., & Thiruvengadam, A. (2011) · Attention deficit and hyperactivity disorders · doi:10.1007/s12402-011-0057-z · Cited by 3
Treatment of cognitive dysfunction in adults with major depressive disorder
McIntyre, R. S., Syeda, K., & Cha, D. S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139860567.020 · Cited by 3
Self-citation
The Interplay between Maternal Depression and ADHD Symptoms in Predicting Emotional and Attentional Functioning in Toddlerhood
Levy, M., Berger, A., Egotubov, A., Gordon‐Hacker, A., Sheiner, E., & Gueron‐Sela, N. (2025) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-025-01332-y · Cited by 2
Gene co-expression networks in peripheral blood capture dimensional measures of emotional and behavioral problems from the Child Behavior Checklist (CBCL)
Hess, J., Nguyen, N. H., Suben, J., Meath, R. M., Albert, A. B., Orman, S. V., Anders, K. M., Forken, P. J., Roe, C. A., Schulze, T. G., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01007-w · Cited by 2
Assessment and treatment of depressive disorders in adults with ADHD
Prince, J. B. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139035491.009 · Cited by 1
Anxiety symptoms are distinctly related to working memory deficits in adults with ADHD
Rauch, A. A., Soble, J. R., & Silton, R. L. (2025) · Applied Neuropsychology Adult · doi:10.1080/23279095.2024.2449170 · Cited by 8
Persian Manuscript of Adult Attention Deficit Hyperactivity Disorder Rating Scale Expected Internal Consistency and Factor Structure in Iranian Medical Students
Shekari, H., Nahavandi, A., & Ahmadi, M. (2017) · Annals of Military and Health Sciences Research · doi:10.5812/amh.68579 · Cited by 1
Adult ADHD in Psychiatric Conditions
Pallanti, S., & Salerno, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-39051-8_6 · Cited by 1
Adult ADHD in Depressive Disorders
Pallanti, S., & Salerno, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-39051-8_10 · Cited by 1
Diagnostic de la comorbidité du Trouble de Déficit Attentionnel et d’Hyperactivité (TDAH) chez les patients bipolaires adultes
Boumendjel, M. D. (2014) · HAL
Sosyal Anksiyete Bozukluğu ve Dikkat Eksikliği Hiperaktivite Bozukluğu Birlikteliğiof Social Anxiety Disorder and Attention Deficit Hyperactivity Disorder
Koyuncu, A., & Binbay, Z. (2014)
ADHD Comorbidities with Depression, Anxiety, and Suicide
Sadek, J. R. (2016) · Springer eBooks · doi:10.1007/978-3-319-39794-8_4
When Bipolar Disorder Mimics ADHD
Baum, R., & Lindle, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-62393-7_12
Neurobiology and Management of Attention-Deficit/Hyperactivity Disorder and Co-Occurring Major Depressive Disorder: Complications and Strategies
Kayongo, B. (2020) · EAS Journal of Pharmacy and Pharmacology · doi:10.36349/easjpp.2020.v02i06.005
Major depressive disorder: how to evaluate and manage patients with psychiatric and medical comorbidities
Wang, S., & Pae, C. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198746638.003.0019
ADHD and Bipolar Disorder
Baum, R., & Lindle, L. (2025) · Springer eBooks · doi:10.1007/978-3-031-96950-8_13
Comorbidities and comedication among individuals in treatment for ADHD: a Danish nationwide study
Vestergaard, M., Hansen, R. F., Thomsen, P. H., Bentsen, A. H., & Falch-Joergensen, A. C. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-07824-5
Similitudes et différences entre le TDAH et le TSA, illustrées par l’étude du défaut d’inhibition
Septier, M. (2019) · theses.fr (ABES) · doi:10.70675/22fe83c2z678fz4b7ezac95z1af4554dfcbf
Retrospective childhood attention-deficit/hyperactivity disorder traits and their differential associations with mood disorder presentations in adulthood
Jwa, Y., Lee, J., Yu, H.-S., Lee, C.-W., Hur, H. J., Do, H. S., Lim, J., Lim, S.-W., Kim, J., Hwang, I.-A., et al. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02251-9

Authors: McIntyre, R. S., Kennedy, S. H., Soczynska, J. K., Nguyen, H. T. T., Bilkey, T. S., Woldeyohannes, H. O., Nathanson, J. A., Joshi, S., Cheng, J. S. H., Benson, K. M., & Muzina, D. J.
Affiliations: University of Toronto (CA)
Corresponding author: McIntyre, Roger S.
ORCID: McIntyre, Roger S.
Kennedy, Sidney H.
Soczynska, Joanna K.
Joshi, Shikha
Venue: The Primary Care Companion to The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2010-05-27
Volume: 12
Issue: 3
ISSN: 1523-5998 (ISSN-L)
1555-211X
DOI: 10.4088/pcc.09m00861gry
PMC: PMC2947541
OpenAlex: W2060511695
Cited by: 103
References: 3
Citations by year: 2026: 5 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 13 · 2013: 5 · 2012: 7
FWCI: 2.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Primary Care Companion to The Journal of Clinical Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: adult ADHD, bipolar disorder, major depressive disorder, comorbidities, age of onset, psychiatric comorbidity, quality of life, disease burden

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Attention-Deficit/Hyperactivity Disorder in Adults With Bipolar Disorder or Major Depressive Disorder: Results From the International Mood Disorders Collaborative Project

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