The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Ropivacaine: A review of its pharmacology and clinical use
Open accessAbstract
Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. The drug displays linear and dose proportional pharmacokinetics (up to 80 mg administered intravenously). It is metabolised extensively in the liver and excreted in urine. The present article details the clinical applications of ropivacaine and its current place as a local anaesthetic in the group.
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Cites
Knudsen, K., Beckman Suurküla, M., Blomberg, S., Sjövall, J., & Edvardsson, N. (1997) · British Journal of Anaesthesia · doi:10.1093/bja/78.5.507 · Cited by 1,009
Ropivacaine: A Review of its Use in Regional Anaesthesia and Acute Pain Management
Simpson, D., Curran, M. P., Oldfield, V., & Keating, G. M. (2005) · Drugs · doi:10.2165/00003495-200565180-00013 · Cited by 178
Disposition Kinetics of Ropivacaine in Humans
Lee, A. S. Y., Fagan, D., Lamont, M., Tucker, G. T., Halldin, M. M., & SCOTT, D. B. (1989) · Anesthesia & Analgesia · doi:10.1213/00000539-198912000-00008 · Cited by 146
Ekström, G., & Gunnarsson, U. B. (1996) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07489-6 · Cited by 83
Kindler, C. H., Paul, M., Zou, H. L., Liu, C., Winegar, B. D., Gray, A. T., & Yost, C. S. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049809 · Cited by 82
Wulf, H., Biscoping, J., Beland, B., Bachmann‐Mennenga, B., & Motsch, J. (1999) · Anesthesia & Analgesia · doi:10.1213/00000539-199907000-00019 · Cited by 75
Jayr, C., Beaussier, M., Gustafsson, U., et al. (1998) · British Journal of Anaesthesia · doi:10.1093/bja/81.6.887 · Cited by 51
Lorenzini, C., Moreira, L. B., & Ferreira, M. B. C. (2002) · Anaesthesia · doi:10.1046/j.0003-2409.2001.02393.x · Cited by 50
Cited by
Sawicki, C. M., Kim, J. K., Weber, M. D., Jarrett, B. L., Godbout, J. P., Sheridan, J. F., & Humeidan, M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.11.005 · Cited by 17
Metadata
- Authors
- Kuthiala, G., & Chaudhary, G.
- Venue
- Indian Journal of Anaesthesia
- Published
- 2011-03
- Volume
- 55
- Issue
- 2
- Pages
- 104-110
- ISSN
- 0019-5049 (ISSN-L)
- 0976-2817
- OpenAlex
- W1964895428
- Cited by
- 440
- References
- 8
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- diamond
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