Reverse phase high performance liquid chromatographic method for the analysis of letrozole in pharmaceutical dosage forms
Open accessAbstract
A rapid and sensitive reverse phase high performance liquid chromatographic method is depicted for the qualitative and quantitative assay of letrozole in pharmaceutical dosage forms. Letrozole was chromatographed on a reverse phase C18 column with a mobile phase consisting of acetonitrile and phosphate buffer (pH 7.8) in the ratio of 70:30 v/v. The mobile phase was pumped at a flow rate of 1 ml/min. Acenaphthene was used as an internal standard and the eluents were monitored at 232 nm. The retention time of the drug was 3.385 min. With this method, linearity was observed in the range of 10-100 mug/ml. The LOD and LOQ were found to be 0.51 mug/ml and 1.52 mug/ml, respectively. The method was found to be applicable for analysis of drug in tablets. The results of the analysis were validated statistically.
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Research works printed but not linked: 4
- [1]Barrows LR Gennaro AR Antineoplastic and immunoactive drugs Remington: The Science and Practice of Pharmacy 2000 Vol II 20th ed Philadelphia, PA Lippincott Williams and Wilkins Company 1477 506
- [2]Lamb HM Adkins JC Letrozole: A review of its use in postmenopausal women with advanced breast cancer Drugs 1998 56 6 1125 40 9878997
- [4]Mouridsen H Gershanovich M Sun Y Superior efficacy of Letrozole versus Tamoxifen as first line therapy for postmenopausal women with advanced breast cancer J Clin Oncol 2001 19 10 2596 606 11352951
- [6]Itoh T Karlsberg K Kijima I Yuan YC Smith D Letrozole: A microarray Approach Mol Cancer Res 2005 3 4 203 18 15831674
Cited by
Sorted by citations
Acharjya, S., Mallick, P., Panda, P., Kumar, K., & Annapurna, M. (2010) · Journal of Advanced Pharmaceutical Technology & Research · doi:10.4103/0110-5558.72425 · Cited by 46 · see citing works
“On a detailed literature survey, it was found that letrozole could be estimated by spectrophotometry,[3-4] Highperformance liquid chromatography (HPLC),[5-10] the microarray approach,[11] capillary gas chromatographic method with flame ionization detector,[12] and by gas chromatography – mass sprectrometry (GC / MS)[1…”
MethodHegde, A. R., Padya, B. S., Soman, S., & Mutalik, S. (2021) · Journal of Analytical Science and Technology · doi:10.1186/s40543-021-00276-4 · Cited by 17 · see citing works
“…al. 2012) Several analytical techniques such as UV spectropho- tometry, liquid chromatography, gas chromatography, and mass spectrophotometry have been reported for the estimation of LTZ either alone or in combination (Berzas et al. 2003; Mareck et al. 2005; Mondal et al. 2007; Laha et al. 2008).”
Method
- Authors
- Sen, S., Laha, T., & Patnaik, R.
- Corresponding author
- Sen, S
- Venue
- Indian Journal of Pharmaceutical Sciences
- Publisher
- OMICS Publishing Group
- Published
- 2008
- Volume
- 70
- Issue
- 3
- Pages
- 401
- ISSN
- 0250-474X (ISSN-L)
- PMC
- PMC2792508
- OpenAlex
- W2084069543
- Cited by
- 17
- References
- 0
- Citations by year
- 2025: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 3
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by
- Locations
- Indian Journal of Pharmaceutical Sciences (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Keywords
- letrozole, reversed-phase HPLC, pharmaceutical dosage forms, tablets, method validation, C18 column
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