Effect of surgical and non-surgical periodontal debridement on vascular thrombotic markers in hypertensives
Open accessAbstract
BACKGROUND: Periodontal debridement has an impact on the vascular thrombotic markers in healthy individuals. This study aimed to investigate changes in several vascular thrombotic markers after surgical and non-surgical periodontal debridement in hypertensives with periodontitis. MATERIALS AND METHODS: 40 hypertensives, 27 males and 13 females, 37-68 year old, mean 51.2 years, with moderate to severe periodontitis, were divided into two groups, (n = 20 for each); the first received comprehensive one session non-surgical periodontal debridement, (pockets 4-6 mm), while the second received comprehensive supragingival scaling with surgical debridement at one quadrant, (Pockets > 6 mm). Periodontal parameters included; plaque index (PI), gingival inflammation (GI), bleeding on probing (BOP), pocket probing depth (PPD). Vascular thrombotic tests included; platelets count (Plt), fibrinogen (Fib), Von Willebrand factor antigen activity (vWF:Ag), and D-dimers (DD). RESULTS: PI, GI, BOP, PPD, decreased significantly (P = 0.001) after 6 weeks of periodontal debridement in both groups, while BOP and PPD remained higher in the surgical one (P < 0.05). Thrombotic vascular markers changes through the three-time intervals were significant in each group (P = 0.001), and time-group interception effect was significant for vWF:Ag (P = 0.005), while no significant differences between groups after treatment (P > 0.05). CONCLUSION: Periodontal debridement, surgical and non-surgical, improved the periodontal status in hypertensives. Periodontal treatment activated the coagulation system in hypertensives and recessed later while the treatment modality did not affect the degree of activation.
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Platelet count, fibrinogen, vWF:Ag, and D-Dimer levels increased after 48 h of treatment and decreased after 6 weeks in hypertensive patients with periodontitis, with no significant differences between groups.
“Platelet count, fibrinogen, Von Willebrand factor antigen (vWF:Ag), and D-Dimer levels increased after 48 h of treatment (scaling of the teeth including subgingival root debridement for half of the patients and surgical periodontal therapy for the other 20) and decreased after 6 weeks (P < 0.05), with no significant differences between groups (P > 0.05).”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [57]
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References 27 · Cited by 7
Research works printed but not linked: 8
- [1]Al Tayebb W Evaluating periodontitis role as a risk factor in atherosclerosis PhD, Thesis 2007 Damascus University of Damascus 120 33
- [11]Topol EJ Califf RM Textbook of Vascular Medicine 2002 2nd ed Philadelphia Lippincott Williams and Wilkins 91 122
- [12]Newman M Newman M Palisano R Carranza F Taka H Classification of diseases and conditions affecting the periodontium Clinical Periodontology 2006 10th ed Missouri Saunders Elsevier 100 9
- [17]Dacie S Lewis B Practical Haematology 2001 9th ed Philadelphia Churchill Livingstone Elsevier 353 60
- [18]Henry JB Clinical diagnosis and management by laboratory methods 2001 1 20th ed Philadelphia W.B. Saunders Company 821 48
- [19]Lewandrowski K Clinical chemistry: Laboratory management and clinical correlations 2002 Philadelphia Lippincott Williams and Willkins 365 74
- [31]AlBush MM Khattab R Studying vascular thrombotic markers in chronic periodontitis with hypertension J Damascus Univ Med Sci 2011 In Press
- [33]AlBush MM Khattab R Effect of non-surgical and surgical periodontal debridement on vascular thrombotic markers in chronic periodontitis J Damascus Univ Med Sci 2011 In Press
- Authors
- Al Bush, M., Razan, K., & Raed, A. D.
- Affiliations
- Damascus University (SY)
- Venue
- Journal of Indian Society of Periodontology
- Published
- 2013
- Volume
- 17
- Issue
- 3
- Pages
- 324
- ISSN
- 0972-124X (ISSN-L)
- PMC
- PMC3768182
- OpenAlex
- W2093574423
- Cited by
- 7
- References
- 27
- Citations by year
- 2025: 1 · 2023: 3 · 2021: 2 · 2019: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Indian Society of Periodontology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- scaling and root planing, periodontitis, hypertension, von Willebrand factor, fibrinogen, D-dimer, platelet count, supragingival scaling, surgical debridement, coagulation activation, periodontal parameters
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