Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 15Oral and gingival health researchOral microbiology and periodontitis researchOral Health Pathology and Treatment

The DOI matches its Crossref record.

Sodium valproate induced gingival enlargement with pre-existing chronic periodontitis

Open access
Joshipura, Vaibhavi·2012·Journal of Indian Society of Periodontology
DOI 10.4103/0972-124x.99277PMC PMC3459514
Open this paper in CoChat — free account

Abstract

Gingival enlargement is a common clinical feature of gingival and periodontal diseases. Currently, more than 20 prescription medications are associated with gingival enlargement. Although the mechanisms of action may be different, the clinical and microscopic appearance of drug-induced gingival enlargement is similar with any drug. Gingival enlargement produces esthetic changes, and clinical symptoms including pain, tenderness, bleeding, speech disturbances, abnormal tooth movement, dental occlusion problems, enhancement of caries development and periodontal disorders. Sodium valproate is considered to produce gingival enlargement, but very rarely. This case report features sodium valproate induced gingival enlargement in a patient with pre-existing chronic periodontitis, who came to the Dental Department, Chinmaya Mission Hospital, Bangalore. The case is special as the patient did not develop the enlargement in spite of taking phenytoin for 1 year and developed enlargement with sodium valproate within 6 months.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4103/0972-124x.99277

Cites

Statistics

Figures

Figure 1 Sodium valproate induced gingival enlargement
Figure 1 Sodium valproate induced gingival enlargementCC BY-NC-SA · PubMed Central
Figure 2 Right side preoperative view
Figure 2 Right side preoperative viewCC BY-NC-SA · PubMed Central
Figure 3 Left side preoperative view
Figure 3 Left side preoperative viewCC BY-NC-SA · PubMed Central
Figure 4 OPG showing moderate to severe bone loss
Figure 4 OPG showing moderate to severe bone lossCC BY-NC-SA · PubMed Central
Figure 5 Right side postoperative view
Figure 5 Right side postoperative viewCC BY-NC-SA · PubMed Central
Figure 6 Left side postoperative view
Figure 6 Left side postoperative viewCC BY-NC-SA · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 10

  1. [1]Dongari-Bagtzoglou A Drug-Associated Gingival Enlargement J Periodontol 2004 75 1424 31 15562922
  2. [2]Hallmon WW Rossmann JA The role of drugs in the pathogenesis of gingival overgrowth Periodontol 2000 1999 21 176 10551182
  3. [3]Seymour RA Thomason JM Ellis JS The pathogenesis of drug-induced gingival overgrowth J Clin Periodontol 1996 23 165 75 8707974
  4. [5]Brunet L Miranda J Farre M Berini L Mendieta C Gingival enlargement induced by dugs Drug Saf 1996 15 219 31 8879976
  5. [6]Tan H Gürbüz T Dağsuyu IM Gingival Enlargement in Children Treated With Antiepileptics J Child Neurol 2004 19 958 63 15704870
  6. [7]Seymour RA Smith DG Turnbull DN The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients J Clin Periodontol 1985 12 413 9 3926831
  7. [8]Armitage GC Develpoment of a classification system for periodontal diseases and conditions Ann Periodontol 1999 4 1 6 10863370
  8. [9]Seymour RA Effects of medications on the periodontal tissues in health and disease Periodontol 2000 2006 40 120 9 16398689
  9. [10]Kato T Okahashi N Ohno T Inaba H Kawai S Amano A Effect of phenytoin on collagen accumulation by human gingival fibroblasts exposed to TNF-alpha in vitro Oral Dis 2006 12 156 62 16476037
  10. [11]Kataoka M Kido J Shinohara Y Nagata T Drug - induced gingival overgrowth – A review Biol Pharm Bull 2005 28 1817 21 16204928

Cited by

See all 15

Metadata

Authors
Joshipura, V.
Corresponding author
Joshipura, Vaibhavi
Venue
Journal of Indian Society of Periodontology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012
Volume
16
Issue
2
Pages
278
ISSN
0972-124X (ISSN-L)
DOI
10.4103/0972-124x.99277
PMC
PMC3459514
OpenAlex
W2042863482
Cited by
15
References
0
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 6 · 2014: 2
FWCI
1.50
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Journal of Indian Society of Periodontology (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral and gingival health research
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords
drug-induced gingival hyperplasia, valproic acid, chronic periodontitis, phenytoin, antiepileptic drugs, gingival hyperplasia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Sodium valproate induced gingival enlargement with pre-existing chronic periodontitis. https://app.cochat.ai/papers/10.4103/0972-124x.99277
The paper
Joshipura, V. (2012). Sodium valproate induced gingival enlargement with pre-existing chronic periodontitis. Journal of Indian Society of Periodontology. https://doi.org/10.4103/0972-124x.99277

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.