A multicomponent yoga-based, breath intervention program as an adjunctive treatment in patients suffering from generalized anxiety disorder with or without comorbidities
Open accessAbstract
OBJECTIVES: The aim of this study is to evaluate the efficacy and tolerability of Sudarshan Kriya Yoga (SKY) course in generalized anxiety disorder (GAD) outpatients, who after eight weeks of an appropriate dose of traditional therapy had not yet achieved remission. SUBJECTS: The adult participants (18-65 years) were outpatients with a primary diagnosis of GAD with or without comorbidities on the Mini-International Neuropsychiatric Interview (MINI). Participants had a minimum of eight weeks standard treatment with an appropriate dose of a standard prescription anxiolytic, a clinician global impression-severity (CGI-S) score of 5-7, a Hamilton anxiety scale (HAM-A) total score ≥20 including a score of >2 on the anxious mood and tension items. MATERIALS AND METHODS: Forty-one patients were enrolled in an open-label trial of the SKY course as an adjunct to standard treatment of GAD at the START Clinic for Mood and Anxiety Disorders, a tertiary care mood and anxiety disorder clinic in Toronto. The SKY course was administered over five days (22 h total). Subjects were encouraged to practice the yoga breathing techniques at home for 20 min per day after the course and were offered group practice sessions for 2 h once a week led by certified yoga instructors. The primary outcome measure was the mean change from pre-treatment on the HAM-A scale. Psychological measures were obtained at baseline and four weeks after completing the intervention. RESULTS: Thirty-one patients completed the program (mean age 42.6 ± 13.3 years). Among completers, significant reductions occurred in the pre- and post-intervention mean HAM-A total score (t=4.59; P<0.01) and psychic subscale (t=5.00; P≤0.01). The response rate was 73% and the remission rate 41% as measured on the HAM-A. CONCLUSION: The results of this small pilot trial suggest that the SKY course represents a potentially valuable adjunct to standard pharmacotherapy in patients with GAD or treatment-resistant GAD, and warrants further investigation. In particular, changes in worry and body symptoms showed significant improvements that may further our understanding of the mechanism of change in the tolerance of anxiety and worry.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The higher costs of pharmacological therapies gave rise to the use of alternative methods of treatment.
“The higher costs of pharmacological therapies, gave rise to the use of alternative methods of treatment [46] .”
From Alternative Medicine: New Ways to Treat Diseases and Therapies (2021) · cites this paper as [46]
The Introduction describes limitations of medication for generalized anxiety disorder, including side effects and variable response, and the Conclusion reports a yoga-based intervention used alongside standard treatment. Neither section says that high costs of pharmacological therapies gave rise to alternative treatments; that causal explanation is unsupported. Page numbers are unavailable in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 62 · Cited by 89
Research works printed but not linked: 47
- [1]Kessler RC Berglund P Demler O Jin R Merikangas KR Walters EE Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication Arch Gen Psychiatry 2005 62 593 602 15939837
- [2]Kessler RC Chiu WT Demler O Walters EE Prevalence, severity, and comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication Arch Gen Psychiatry 2005b 62 617 27 15939839 PMC2847357
- [6]Wittchen HU Generalized Anxiety Disorder: Prevalence Burden, and Cost to Society Depress Anxiety 2002 16 162 71 12497648
- [7]Wittchen HU Zhao S Kessler RC Eaton WW DSM-III-R generalized anxiety disorder in the National Comorbidity Survey Arch Gen Psychiatry 1994 51 355 64 8179459
- [8]Massion AO Warshaw MG Keller MB Quality of life and psychiatric morbidity in panic disorder and generalized anxiety disorder Am J Psychiatry 1993 150 600 7 8465877
- [9]Olfson M Fireman B Weissman MM Leon AC Sheehan DV Kathol RG Mental disorders and disability among patients in a primary care group practice Am J Psychiatry 1997 154 1734 40 9396954
- [10]Brawman-Mintzer O Lydiard RB Generalized anxiety disorder: Issues in epidemiology J Clin Psychiatry 1996 57 Suppl 7 3 8 8690694
- [11]Ballenger JC Update on anxiety disorders Arch Intern Med 1991 151 857 9 2025132
- [12]Montgomery SA Pregabalin for the treatment of generalised anxiety disorder Expert Opin Pharmacother 2006 7 2139 54 17020438
- [13]Kennedy SH Eisfeld BS Cooke RG Quality of life: An important dimension in assessing the treatment of depression J Psychiatry Neurosci 2001 26 Suppl S23 8 11590966 PMC2553258
- [14]Kennedy SH Dickens SE Eisfeld BS Bagby RM Sexual dysfunction before antidepressant therapy in major depression J Affect Disord 1999 56 201 8 10701478
- [15]Michelini S Cassano GB Frare F Perugi G Long-term use of benzodiazepines: Tolerance, dependence and clinical problems in anxiety and mood disorders Pharmacopsychiatry 1996 29 127 34 8858711
- [16]Baldwin DS Nair RV Escitalopram in the treatment of generalized anxiety disorder Expert Rev Neurother 2005 5 443 9 16026227
- [17]Gelenberg AJ Lydiard RB Rudolph RL Aguiar L Haskins JT Salinas E Efficacy of venlafaxine extended-release capsules in nondepressed outpatients with generalized anxiety disorder: A 6-month randomized controlled trial JAMA 2000 283 3082 8 10865302
- [18]Pollack MH Zaninelli R Goddard A McCafferty JP Bellew KM Burnham DB Paroxetine in the treatment of generalized anxiety disorder: Results of a placebo-controlled, flexible-dosage trial J Clin Psychiatry 2001 62 350 7 11411817
- [19]Rickels K Downing R Schweizer E Hassman H Antidepressants for the treatment of generalized anxiety disorder.A placebo-controlled comparison of imipramine, trazodone, and diazepam Arch Gen Psychiatry 1993 50 884 95 8215814
- [20]Katzman MA Vermani M Jacobs L Marcus M Kong B Lessard S Quetiapine as an adjunctive pharmacotherapy for the treatment of non-remitting generalized anxiety disorder: A flexible-dose, open-label pilot trial J Anxiety Disord 2008 22 1480 6 18455360
- [21]Andrews G Sanderson K Slade T Issakidis C Why does the burden of disease persist.Relating the burden of anxiety and depression to effectiveness of treatment? Bull World Health Organ 2000 78 446 54 10885163 PMC2560749
- [22]Covin R Ouirret AJ Seeds PM Dozois DJ A meta-analysis of CBT for pathological worry among clients with GAD J Anxiety Disord 2008 22 108 16 17321717
- [23]Durham RC Chambers JA MacDonald RR Power KG Major K Does cognitive-behavioural therapy influence the long-term outcome of GAD.An 8-14 year follow-up of two clinical trials? Psychol Med 2003 33 499 509 12701670
- [24]Brown RP Gerbarg PL Sudarshan Kriya yogic breathing in the treatment of stress, anxiety, and depression: Part I-neurophysiologic model J Altern Complement Med 2005 11 189 201 15750381
- [26]Brown RP Gerbarg PL Sudarshan kriya yogic breathing in the treatment of stress, anxiety, and depression: Part II-Clinical applications and guidelines J Comp and Alt Med 2005 11 711 7 16131297
- [28]Lavey R Sherman T Mueser KT Osborne DD Currier M Wolfe R The effects of yoga on mood in psychiatric inpatients Psychiatr Rehabil J 2005 28 399 402 15895926
- [29]Ray US Mukhopadhyaya S Purkayastha SS Asnani V Tomer OS Prashad R Effect of yogic exercises on physical and mental health of young fellowship course trainees Indian J Physiol Pharmacol 2001 45 37 53 11211570
- [30]Malathi A Damodaran A Stress due to exams in medical students--role of yoga Indian J Physiol Pharmacol 1999 43 218 24 10365315
- [31]Janakiramaiah N Gangadhar BN Naga Venkatesha Murthy PJ Harish MG Subbakrishna DK Vedamurthachar A Antidepressant efficacy of Sudarshan Kriya Yoga (SKY) in melancholia: A randomized comparison with electroconvulsive therapy (ECT) and imipramine J Affect Disord 2000 57 255 9 10708840
- [33]Naga Venkatesha Murthy PJ Janakiramaiah N Gangadhar BN Subbakrishna DK P300 amplitude and antidepressant response to Sudarshan Kriya Yoga (SKY) J Affect Disord 1998 50 45 8 9716279
- [34]Vedamurthachar A Janakiramaiah N Hegde JM Shetty TK Subbakrishna DK Sureshbabu SV Antidepressant efficacy and hormonal effects of Sudarshan Kriya Yoga (SKY) in alcohol dependent individuals J Affect Disord 2006 94 249 53 16740317
- [35]Carter JJ Byrne GG Brown RP Gerbarg PL Multi-component Yoga Breath Based Program Reduces PTSD in Australian Vietnam War Veterans: A Randomized Controlled Trial 2009 Los Angeles, CA Symposium on Yoga Therapy and Research
- [36]Gerbarg PL Anderson FS Yoga and Neuro-psychoanalysis Bodies in Treatment: The Unspoken Dimension 2007 Hillsdale NJ The Analytic Press Inc 132 3
- [37]Sageman S Breaking through the despair: Spiritually oriented group therapy as a means of healing women with severe mental illness J Am Acad Psychoanal Dyn Psychiatry 2004 32 125 41 15132194
- [38]Descilo T Vedamurtachar A Gerbarg PL Nagaraja D Gangadhar BN Damodaran B Effects of a yoga-breath intervention alone and in combinations with an exposure therapy for PTSD and depression in survivors of the 2004 Southeast Asian tsunami Acta Psychiatr Scand 2010 12 289 300 19694633
- [40]Bhatia M Kumar A Kumar N Pandey RM Kochupillai V Electrophysiologic evaluation of Sudarshan Kriya: An EEG, BAER, P300 study Indian J Physiol Pharmacol 2003 47 157 63 15255618
- [41]Sharma H Sen S Singh A Bhardwaj NK Kochupillai V Singh N Sudarshan Kriya practitioners exhibit better antioxidant status and lower blood lactate levels Biol Psychol 2003 63 281 91 12853172
- [43]Sheehan DV Lecrubier Y Sheehan KH Amorim P Janavs J Weiller E The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 J Clin Psychiatry 1998 59 suppl 20 22 33 9881538
- [44]Hamilton M The assessment of anxiety states by rating Br J Med Psychol 1959 32 50 5 13638508
- [45]Pollack MH Simon NM Zalta AK Worthington JJ Hoge EA Mick E Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: A placebo controlled study Biol Psychiatry 2006 59 211 21 16139813
- [46]Reiss S McNally RJ Reiss S McNally RJ The expectancy model of fear Theoretical issues in behavior therapy 1985 New York Academic Press 107 21
- [50]Beck AT Epstein N Brown G Steer RA An inventor for measuring clinical anxiety: Psychometric properties J Consult Clin Psychol 1988 56 893 7 3204199
- [52]Osman A Kopper BA Barrios FX Osman JR Wade T The Beck Anxiety Inventory: Reexamination of factor structure and psychometric properties J Clin Psychol 1997 53 7 14 9120035
- [57]Buhr K Dugas MJ The intolerance of uncertainty scale: Psychometric properties of the English version Behav Res Ther 2002 40 931 45 12186356
- [59]Hewitt PL Flett GL Perfectionism in the self and social contexts: Conceptualization, assessment, and association with psychopathology J Pers Soc Psychol 1991 60 456 70 2027080
- [61]Connor KM Davidson JR Churchill LE Sherwood A Foa E Weisler RH Psychometric properties of the Social Phobia Inventory (SPIN): New self rating scale Br J Psychiatry 2000 176 379 86 10827888
- [64]Stanley MA Wilson NL Nony DM Rhoades HM Wagener PD Greisinger AJ Cognitive behavioural therapy for generalized anxiety disorder among older adults in primary care: A randomized clinical trial JAMA 2009 301 1460 7 19351943 PMC3328789
- [66]Stein DJ Ahokas AA Bodinat C Efficacy of agomeltine in generalized anxiety disorder: A randomized, double-blind, placebo-controlled study J Clin Psychopharmacol 2008 28 561 6 18794654
- [67]Ferrero A Piero A Fassina S Massola T Lanteri A Daga GA A 12-month comparison of brief psychodynamic psychotherapy and pharmacotherapy treatment in subjects with generalized anxiety disorders in a community setting Eur Psychiatry 2007 22 530 9 17900875
- [68]Nimatoudis I Zissis NP Kogeorgos J Theodoropoulou S Vidalis A Kaprinis G Remission rates with venlafaxine extended release in Greek outpatients with generalized anxiety disorder. A double-blind, randomized, placebo controlled study Int Clin Psychopharmacol 2004 19 331 6 15486518
- Authors
- Katzman, M., Vermani, M., Gerbarg, P., Brown, R., Iorio, C., Davis, M., Cameron, C., & Tsirgielis, D.
- Affiliations
- START Clinic (CA)
- Columbia University (US)
- Lakehead University (CA)
- University of Guelph (CA)
- Venue
- International Journal of Yoga
- Published
- 2012
- Volume
- 5
- Issue
- 1
- Pages
- 57
- ISSN
- 0973-6131 (ISSN-L)
- PMC
- PMC3276935
- OpenAlex
- W1990876673
- Cited by
- 89
- References
- 62
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 11 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 2
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- International Journal of Yoga (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- Sudarshan Kriya Yoga, generalized anxiety disorder, adjunctive therapy, treatment-resistant anxiety, comorbid anxiety disorders, yoga breathing techniques, worry, tolerability, Hamilton Anxiety Rating Scale
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review