The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Zolpidem induced delirium
Open accessAbstract
Use of non-benzodiazepine hypnotics like zolpidem for insomnia has become a popular practice because of better safety profile and low abuse potential. However, neuropsychiatric side-effects such as headache, depression, memory deficits and abnormal dreams with zolpidem use have been reported. Delirum is a rare side-effect associated with zolpidem use. Here, we report a case of delirium, which occurred with a single dose of zolpidem. Clinicians prescribing zolpidem for insomnia should look into the risk factors/pre-disposing factors such as old age, female gender, substance abuse/dependence, systemic infections, psychiatric illness and multiple drug interactions. It is recommended to stick to the lowest dose possible whenever indicated.
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“With increased Z-drug use, a range of serious adverse effects has been identified, including delirium, sleep-related eating disorder, amnesia, and complex behaviors such as sleep-driving; these effects may occur at therapeutic doses, and they are intensified by alcohol or other sedatives.”
From Z-drug abuse and dependence: Clinical guideline of the Brazilian Academy of Neurology for diagnosis and management (2025) · cites this paper as [13]
Citations
Cites
Hajak, G., Müller, W. E., Wittchen, H. U., Pittrow, D., & Kirch, W. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00491.x · Cited by 404
Addiction: Part I. Benzodiazepines--side effects, abuse risk and alternatives.
Longo, L. P., & Johnson, B. (2000) · PubMed · Cited by 302
Central Nervous System Side Effects Associated with Zolpidem Treatment
Toner, L. C., Tsambiras, B. M., Catalano, G., Catalano, M. C., & Cooper, D. S. (2000) · Clinical Neuropharmacology · doi:10.1097/00002826-200001000-00011 · Cited by 273
Victorri‐Vigneau, C., Dailly, E., Veyrac, G., & Jolliet, P. (2007) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.02861.x · Cited by 201
The safety and tolerability of zolpidem — an update
DARCOURT, G., Pringuey, D., Sallière, D., & Lavoisy, J. (1999) · Journal of Psychopharmacology · doi:10.1177/026988119901300109 · Cited by 139
Roger, M., Attali, P., & Jp, C. (1993) · PubMed · Cited by 86
Zolpidem dependence case series: possible neurobiological mechanisms and clinical management
Liappas, I., Malitas, P. N., Dimopoulos, N. P., Gitsa, O. E., Liappas, A., Nikolaou, C. K., & Christodoulou, G. N. (2003) · Journal of Psychopharmacology · doi:10.1177/0269881103017001723 · Cited by 80
Delirium Associated with Zolpidem
Brodeur, M. R., & Stirling, A. L. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.10385 · Cited by 51
Zolpidem-Induced Delirium With Mania in an Elderly Woman
Hill, K. P., Oberstar, J. V., & Dunn, E. R. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.1.88 · Cited by 22
Dependence syndrome and intoxication delirium associated with zolpidem.
Sharan, P., Bharadwaj, R. S., Grover, S., Padhy, S. K., Kumar, V., & Singh, J. (2007) · PubMed · Cited by 21
Research works printed but not linked: 1
- Freudenreich, 2000, Zolpidem-related delirium: A case report, J Clin Psychiatry, 449
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Sorted by citations
Abrupt Withdrawal From Chronic High-Dose Zolpidem Use: A Case Report of Resulting Delirium
Awasthi, H., & Vohra, A. (2023) · Cureus · doi:10.7759/cureus.49025 · Cited by 4
Stelzer, F. G., Bacelar, A., Éckeli, A. L., Negrão, A. B., Almeida, C. M. O., Franco, C. M. R., Pires, G. N., Gitaí, L. L. G., Sobreira-Neto, M. A., Assis, M., et al. (2025) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0045-1812323 · Cited by 1
Metadata
- Authors
- Chate, S., Nayak, R., Patil, N., & Chattopadhyay, S.
- Affiliations
- Jawaharlal Nehru Medical College (IN)
- Venue
- Journal of the Scientific Society
- Published
- 2013
- Volume
- 40
- Issue
- 3
- Pages
- 164
- ISSN
- 0974-5009 (ISSN-L)
- OpenAlex
- W1979882131
- Cited by
- 2
- References
- 10
- Citations by year
- 2025: 1 · 2023: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of the Scientific Society (publishedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Keywords
- zolpidem, delirium, non-benzodiazepine hypnotics, insomnia, adverse drug reactions, neuropsychiatric adverse effects, risk factors, drug interactions
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