An Assessment of Psychiatric Disturbances in Graves Disease in a Medical College in Eastern India
Open accessAbstract
BACKGROUND: Graves' disease is a unique conglomeration of cardiovascular, neurological, ophthalmological, and other systemic manifestations. In this study we have tried to explore the psychiatric dimensions of this disease. AIMS: This study attempted to explore clinical features, types, and treatment outcome of psychiatric disturbances in Graves disease. STUDY DESIGN: This is a purposive study following the criteria of DSM IV. MATERIALS AND METHODS: A total of 36 adult patients of newly diagnosed Graves disease and 30 age- and sex-matched controls were included. Data enumerated were age, sex, date of admission, analysis of psychiatric signs, and symptoms by one independent observer, diagnostic categorization, effect of treatment, and outcome. Follow-up evaluation was done after 1 year. Statistical Analysis : Statistical analysis was done by the standard error of difference, the chi-square test, and paired Student's T-test. RESULTS: Among 36 patients 32 were female and 4 were male. Fifteen patients (41.67%) were diagnosed with generalized anxiety disorders (GAD), 6 (16.67%) with mood disorder, 6 (16.67%) with obsessive compulsive disorder (OCD), and 2 each with personality disorder and schizophreniform disorder. The common symptoms were insomnia, irritability, and anxiety. The frequency of GAD was statistically more significant in the Graves disease group in comparison to control. Fourteen patients agreed to take both antithyroid and antipsychotropic medications (group 1). The rest were treated with only antithyroid drug (group 2). There was significant improvement in both groups and no difference between the groups. CONCLUSION: The prevalence of certain psychiatric manifestations in Graves' disease was significantly higher than in the control group. There was no significant difference between therapy with antithyroid drugs and combination of antithyroid with psychotropic medications.
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In Chattopadhyay et al.'s study, both treatment groups showed significant improvement in symptoms of insomnia, irritability, and anxiety.
“The study showed significant improvement in symptoms of insomnia, irritability, and anxiety for both groups.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [7]
The Results report significant improvement in both treatment groups, and the Materials and Methods passage reports significant improvement in psychiatric rating scores at one year. The paper identifies insomnia, irritability, and anxiety as common symptoms, but does not report significant improvement for each of those symptoms separately in both groups. (LLM, conf=0.86)
Experimental — accuracy not yet measuredChattopadhyay et al. assessed 36 patients with newly diagnosed Graves disease and comorbid psychiatric concerns, including 41% with generalized anxiety disorder, 16% with obsessive-compulsive disorder, and 16% with undifferentiated mood disorders.
“Chattopadhyay et al. (7) assessed a group of 36 patients in India with newly diagnosed Graves disease and comorbid psychiatric concerns, including 41% with generalized anxiety disorder, 16% with obsessive-compulsive disorder, and 16% with undifferentiated mood disorders.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [7]
The Materials and Methods passage reports 36 newly diagnosed Graves disease patients, of whom 31 had psychiatric manifestations. It gives 41.67% with generalized anxiety disorder and 16.67% each with obsessive-compulsive disorder and mood disorder, consistent with the cited approximate percentages. It does not describe the mood disorders as “undifferentiated.” No page number is available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn Chattopadhyay et al.'s study, the extent of symptomatic improvement was not significantly different between the two treatment groups.
“However, the extent of symptomatic improvement was not significantly different between groups.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [7]
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Disorders of the Thyroid and Parathyroid
Egan, A., & Dean, D. (2021) · Mental Health, Diabetes and Endocrinology · doi:10.1017/9781911623625.007
- Authors
- Chattopadhyay, C., Chakrabarti, N., & Ghosh, S.
- Affiliations
- KPC Medical College and Hospital (IN)
- Nil Ratan Sircar Medical College and Hospital (IN)
- Corresponding author
- Chattopadhyay, C
- ORCID
- Chattopadhyay, C
- Venue
- Nigerian Journal of Clinical Practice
- Published
- 2012
- Volume
- 15
- Issue
- 3
- Pages
- 276
- ISSN
- 1119-3077 (ISSN-L)
- OpenAlex
- W2010129632
- Cited by
- 23
- References
- 19
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 3 · 2021: 3 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Nigerian Journal of Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- Graves' disease, psychiatric disturbances, generalized anxiety disorder, mood disorders, obsessive-compulsive disorder, personality disorders, schizophreniform disorder, antithyroid drugs, antipsychotic drugs, treatment outcomes, insomnia, irritability, anxiety
- MeSH terms
- Adolescent, Adult, Female, Graves Disease, Humans, India, Male, Middle Aged, Schools, Medical, Antithyroid Agents, Antipsychotic Agents, Young Adult
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