The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies
Open accessAbstract
Colorectal cancer (CRC) is a major health problem in industrialized countries. Although inflammation-linked carcinogenesis is a well accepted concept and is often observed within the gastrointestinal tract, the underlying mechanisms remain to be elucidated. Inflammation can indeed provide initiating and promoting stimuli and mediators, generating a tumour-prone microenvironment. Many murine models of sporadic and inflammation-related colon carcinogenesis have been developed in the last decade, including chemically induced CRC models, genetically engineered mouse models, and xenoplants. Among the chemically induced CRC models, the combination of a single hit of azoxymethane (AOM) with 1 week exposure to the inflammatory agent dextran sodium sulphate (DSS) in rodents has proven to dramatically shorten the latency time for induction of CRC and to rapidly recapitulate the aberrant crypt foci-adenoma-carcinoma sequence that occurs in human CRC. Because of its high reproducibility and potency, as well as the simple and affordable mode of application, the AOM/DSS has become an outstanding model for studying colon carcinogenesis and a powerful platform for chemopreventive intervention studies. In this article we highlight the histopathological and molecular features and describe the principal genetic and epigenetic alterations and inflammatory pathways involved in carcinogenesis in AOM/DSS-treated mice; we also present a general overview of recent experimental applications and preclinical testing of novel therapeutics in the AOM/DSS model.
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Cited by
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Diverging inflammasome signals in tumorigenesis and potential targeting
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The Gut Microbiome Modulates Colon Tumorigenesis
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Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention
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Metadata
- Authors
- Fazio, V., Robertis, M., Massi, E., Poeta, M., Carotti, S., Morini, S., Cecchetelli, L., & Signori, E.
- Venue
- Journal of Carcinogenesis
- Publisher
- Sakun Publishing House
- Published
- 2011
- Volume
- 10
- Issue
- 1
- Pages
- 9
- ISSN
- 0974-6773 (ISSN-L)
- 1477-3163
- OpenAlex
- W2153178471
- Cited by
- 579
- References
- 127
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fazio, V., Robertis, M., Massi, E., Poeta, M., Carotti, S., Morini, S., Cecchetelli, L., & Signori, E. (2011). The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies. Journal of Carcinogenesis. https://doi.org/10.4103/1477-3163.78279
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