APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer′s disease
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Previous studies indicate that other genes in this region, beyond APOE, such as NECTIN2 or APOC1, may be implicated in AD.
“Previous studies also indicate that other genes in this region, beyond APOE, such as NECTIN2 30 or APOC1, 32 may be implicated in AD.”
From A genetic and proteomic comparison of key AD biomarkers across tissues (2024) · cites this paper as [32]
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Cites
The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · cited 1× · see citing works
“The three common polymorphisms in the APOE gene (ε2, ε3, and ε4) encode different ApoE proteins with single amino changes (Verghese et al., 2011).”
BackgroundCruchaga, C., Chakraverty, S., Mayo, K., Vallania, F. L. M., Mitra, R. D., Faber, K., Williamson, J., Bird, T., Diaz-Arrastia, R., Foroud, T. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031039 · Cited by 320 · see citing works
Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
Kok, E., Haikonen, S., Luoto, T., Huhtala, H., Goebeler, S., Haapasalo, H., & Karhunen, P. J. (2009) · Annals of Neurology · doi:10.1002/ana.21696 · Cited by 299 · see citing works
Effect of<i>APOE</i>genotype on amyloid plaque load and gray matter volume in Alzheimer disease
Drzezga, A., Grimmer, T., Henriksen, G., Mühlau, M., Perneczky, R., Miederer, I., Praus, C., Sorg, C., Wohlschläger, A., Riemenschneider, M., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a2e8d0 · Cited by 248 · see citing works
A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease
Nordberg, A., Carter, S. F., Rinne, J., Drzezga, A., Brooks, D. J., Vandenberghe, R., Perani, D., Forsberg, A., Långström, B., Scheinin, N., et al. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2237-2 · Cited by 186 · see citing works
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Research works printed but not linked: 42
- [1]Abildayeva K Berbee JF Blokland A Jansen PJ Hoek FJ Meijer O Lutjohann D Gautier T Pillot T De Vente J Havekes LM Ramaekers FC Kuipers F Rensen PC Mulder M Human apolipoprotein C-I expression in mice impairs learning and memory functions J Lipid Res 2008 49 856 869 18160739
- [3]Bangen KJ Beiser A Delano-Wood L Nation DA Lamar M Libon DJ Bondi MW Seshadri S Wolf PA Au R APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline J Stroke Cerebrovasc Dis 2013 22 1361 1369 23601373 PMC3849195
- [4]Barnes DE Yaffe K The projected effect of risk factor reduction on Alzheimer's disease prevalence Lancet Neurol 2011 10 819 828 21775213 PMC3647614
- [5]Basak JM Verghese PB Yoon H Kim J Holtzman DM Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes J Biol Chem 2012 287 13959 13971 22383525 PMC3340151
- [6]Berbée JF van der Hoogt CC Kleemann R Schippers EF Kitchens RL van Dissel JT Bakker-Woudenberg IA Havekes LM Rensen PC Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis FASEB J 2006 20 2162 2164 16935938
- [7]Caselli RJ Reiman EM Locke DE Hutton ML Hentz JG Hoffman-Snyder C Woodruff BK Alexander GE Osborne D Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment Arch Neurol 2007 64 1306 1311 17846270
- [8]Caselli RJ Reiman EM Osborne D Hentz JG Baxter LC Hernandez JL Alexander GG Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele Neurology 2004 62 1990 1995 15184602
- [9]Corder EH Saunders AM Strittmatter WJ Schmechel DE Gaskell PC Small GW Roses AD Haines JL Pericak-Vance MA Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 1993 261 921 923 8346443
- [11]Cummings JL Mini-Mental State Examination. Norms, normals, and numbers JAMA 1993 269 2420 2421 8479071
- [12]Cuzzo LM Ross-Cisneros FN Yee KM Wang MY Sadun AA Low-density lipoprotein receptor-related protein is decreased in optic neuropathy of Alzheimer disease J Neuroophthalmol 2011 31 139 146 21593627 PMC3106991
- [13]Devan WJ Falcone GJ Anderson CD Jagiella JM Schmidt H Hansen BM Jimenez-Conde J Giralt-Steinhauer E Cuadrado-Godia E Soriano C Ayres AM Schwab K Kassis SB Valant V Pera J Urbanik A Viswanathan A Rost NS Goldstein JN Freudenberger P Heritability estimates identify a substantial genetic contribution to risk and outcome of intracerebral hemorrhage Stroke 2013 44 1578 1583 23559261 PMC3684199
- [15]Elias-Sonnenschein LS Viechtbauer W Ramakers IH Verhey FR Visser PJ Predictive value of APOE-epsilon4 allele for progression from MCI to AD-type dementia: a meta-analysis J Neurol Neurosurg Psychiatry 2011 82 1149 1156 21493755
- [16]Emi M Wu LL Robertson MA Myers RL Hegele RA Williams RR White R Lalouel JM Genotyping and sequence analysis of apolipoprotein E isoforms Genomics 1988 3 373 379 3243553
- [17]Fallin D Kundtz A Town T Gauntlett AC Duara R Barker W Crawford F Mullan M No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample Neurosci Lett 1997 233 145 147 9350853
- [18]Hachinski VC Iliff LD Zilhka E Du Boulay GH McAllister VL Marshall J Russell RW Symon L Cerebral blood flow in dementia Arch Neurol 1975 32 632 637 1164215
- [19]Hollenbach E Ackermann S Hyman BT Rebeck GW Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease Neurology 1998 50 1905 1907 9633759
- [20]Holtzman DM Herz J Bu G Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease Cold Spring Harb Perspect Med 2012 2 a6312 PMC3282491 22393530
- [21]Hong CJ Liu TY Liu HC Wang SJ Fuh JL Chi CW Lee KY Sim CB Epsilon 4 allele of apolipoprotein E increases risk of Alzheimer's disease in a Chinese population Neurology 1996 46 1749 1751 8649585
- [22]Hughes CP Berg L Danziger WL Coben LA Martin RL A new clinical scale for the staging of dementia Br J Psychiatry 1982 140 566 572 7104545
- [23]Jin C Li W Yuan J Xu W Cheng Z Association of the CR1 polymorphism with ate-onset Alzheimer's disease in Chinese Han populations: a meta-analysis Neurosci Lett 2012 527 46 49 22960360
- [24]Jonsson T Stefansson H Steinberg S Jonsdottir I Jonsson PV Snaedal J Bjornsson S Huttenlocher J Levey AI Lah JJ Rujescu D Hampel H Giegling I Andreassen OA Engedal K Ulstein I Djurovic S Ibrahim-Verbaas C Hofman A Ikram MA Variant of TREM2 associated with the risk of Alzheimer's disease N Engl J Med 2013 368 107 116 23150908 PMC3677583
- [25]Kamboh MI Ferrell RE DeKosky ST Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene Neurosci Lett 1998 244 65 68 9572586
- [26]Kang DE Saitoh T Chen X Xia Y Masliah E Hansen LA Thomas RG Thal LJ Katzman R Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease Neurology 1997 49 56 61 9222170
- [29]Kolsch H Ptok U Mohamed I Schmitz S Rao ML Maier W Heun R Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease Am J Med Genet B Neuropsychiatr Genet 2003 121 128 130 12898587
- [30]Kontula K Aalto-Setala K Kuusi T Hamalainen L Syvanen AC Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: convenient alternative to phenotyping by isoelectric focusing Clin Chem 1990 36 2087 2092 2253351
- [31]Lendon CL J Talbot C Craddock NJ Woo Han S Wragg M Morris JC Goate AM Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population Neurosci Lett 1997 222 187 190 9148246
- [32]Li H Wetten S Li L St JP Upmanyu R Surh L Hosford D Barnes MR Briley JD Borrie M Coletta N Delisle R Dhalla D Ehm MG Feldman HH Fornazzari L Gauthier S Goodgame N Guzman D Hammond S Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease Arch Neurol 2008 65 45 53 17998437
- [33]Liu CC Kanekiyo T Xu H Bu G Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy Nat Rev Neurol 2013 9 106 118 23296339 PMC3726719
- [34]Loparev VN Cartas MA Monken CE Velpandi A Srinivasan A An efficient and simple method of DNA extraction from whole blood and cell lines to identify infectious agents J Virol Methods 1991 34 105 112 1955487
- [35]McKhann G Drachman D Folstein M Katzman R Price D Stadlan EM Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease Neurology 1984 34 939 944 6610841
- [36]Meng X D’Arcy C Apolipoprotein E gene environmental risk factors, and their interactions in dementia among seniors Int J Geriatr Psychiatry 2012 28 1005 1014 23255503
- [37]Nagata T Shinagawa S Kuerban B Shibata N Ohnuma T Arai H Nakayama K Yamada H Age-Related Association between Apolipoprotein E epsilon4 and Cognitive Function in Japanese Patients with Alzheimer's Disease Dement Geriatr Cogn Dis Extra 2013 3 66 73 23569459 PMC3618110
- [38]Nillesen WM Smeets HJ van Oost BA Human ApoCI HpaI restriction site polymorphism revealed by the polymerase chain reaction Nucleic Acids Res 1990 18 3428 1972565 PMC330980
- [40]Popp J Meichsner S Kolsch H Lewczuk P Maier W Kornhuber J Jessen F Lutjohann D Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease Biochem Pharmacol 2013 86 37 42 23291240
- [41]Smith GE Bohac DL Waring SC Kokmen E Tangalos EG Ivnik RJ Petersen RC Apolipoprotein E genotype influences cognitive ‘phenotype’ in patients with Alzheimer's disease but not in healthy control subjects Neurology 1998 50 355 362 9484353
- [42]Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CJ Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Alzheimers Dement 2011 7 280 292 21514248 PMC3220946
- [43]Strittmatter WJ Saunders AM Schmechel D Pericak-Vance M Enghild J Salvesen GS Roses AD Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease Proc Natl Acad Sci U S A 1993 90 1977 1981 8446617 PMC46003
- [44]Tiraboschi P Hansen LA Masliah E Alford M Thal LJ Corey-Bloom J Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease Neurology 2004 62 1977 1983 15184600
- [46]Whitehair DC Sherzai A Emond J Raman R Aisen PS Petersen RC Fleisher AS Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment Alzheimers Dement 2010 6 412 419 20813342 PMC2943876
- [47]Woods AG Sokolowska I Taurines R Gerlach M Dudley E Thome J Darie CC Potential biomarkers in psychiatry: focus on the cholesterol system J Cell Mol Med 2012 16 1184 1195 22304330 PMC3823072
- [48]Zhou YT Zhang ZX Chan P He XM Tang MN Wu CB Hong Z Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population Neurosci Lett 2008 444 109 111 18706476
- [49]Zhuang JP Wang G Cheng Q Wang LL Fang R Liu LH Xiong R Zhang Y Gui YX Kang WY Tang HD Chen SD Cognitive impairment and the associated risk factors among the elderly in the Shanghai urban area: a pilot study from China Transl Neurodegener 2012 1 22 23210893 PMC3546888
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A genetic and proteomic comparison of key AD biomarkers across tissues
Marsh, T. W., Western, D., Timsina, J., Gorijala, P., Yang, C., Pastor, P., Liu, M., Morris, J. C., Bateman, R. J., Schindler, S. E., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.14139 · Cited by 6 · see citing works
Self-citation
- Authors
- Zhang, W., Hu, C., Yang, Z., Zhou, Q., Peng, D., Yuan, X., Lv, Z., Pang, S., Jiang, W., Yang, C., Shi, X., Pang, G., Yang, Y., & Xie, H.
- Venue
- Neural Regeneration Research
- Published
- 2014
- Volume
- 9
- Issue
- 6
- Pages
- 653
- ISSN
- 1673-5374
- PMC
- PMC4146240
- Cited by
- 33
- References
- 6
- Language
- en
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