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Cited by 19Retinal Diseases and TreatmentsMicroRNA in disease regulationAngiogenesis and VEGF in Cancer

MicroRNAs in laser-induced choroidal neovascularization in mice and rats: their expression and potential therapeutic targets

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Peplow, PhilipV, Martinez, Bridget·2021·Neural Regeneration Research
DOI 10.4103/1673-5374.295271PMC PMC8067925
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Abstract

Choroidal neovascularization characterizes wet age-related macular degeneration. Choroidal neovascularization formation involves a primarily angiogenic process that is combined with both inflammation and proteolysis. A primary cause of choroidal neovascularization pathogenesis is alterations in pro- and anti-angiogenic factors derived from the retinal pigment epithelium, with vascular endothelium growth factor being mainly responsible for both clinical and experimental choroidal neovascularization. MicroRNAs (miRNAs) which are short, non-coding, endogenous RNA molecules have a major role in regulating various pathological processes, including inflammation and angiogenesis. A review of recent studies with the mouse laser-induced choroidal neovascularization model has shown alterations in miRNA expression in choroidal neovascularization tissues and could be potential therapeutic targets for wet age-related macular degeneration. Upregulation of miR-505 (days 1 and 3 post-laser), miR-155 (day 14) occurred in retina; miR-342-5p (days 3 and 7), miR-126-3p (day 14) in choroid; miR-23a, miR-24, miR-27a (day 7) in retina/choroid; miR-505 (days 1 and 3) in retinal pigment epithelium/choroid; downregulation of miR-155 (days 1 and 3), miR-29a, miR-29b, miR-29c (day 5), miR-93 (day 14), miR-126 (day 14) occurred in retinal pigment epithelium/choroid. Therapies using miRNA mimics or inhibitors were found to decrease choroidal neovascularization lesions. Choroidal neovascularization development was reduced by overexpression of miR-155, miR-188-5p, miR-(5,B,7), miR-126-3p, miR-342-5p, miR-93, miR-126, miR-195a-3p, miR-24, miR-21, miR-31, miR-150, and miR-184, or suppression of miR-505, miR-126-3p, miR-155, and miR-23/27. Further studies are warranted to determine miRNA expression in mouse laser-induced choroidal neovascularization models in order to validate and extend the reported findings. Important experimental variables need to be standardized; these include the strain and age of animals, gender, number and position of laser burns to the eye, laser parameters to induce choroidal neovascularization lesions including wavelength, power, spot size, and duration.

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  • miRNAs play significant roles in the development and progression of CNV.

    “Recent studies in animal models and humans have highlighted the significant roles of miRNAs in the development and progression of CNV 24 .”

    From rAAV-mediated Multi-miRNA Delivery Targeting MAPK Pathway Suppresses Laser-induced Choroidal Neovascularization in Mice (2026) · cites this paper as [24]

    The Discussion reports that altering specific miRNAs significantly affected CNV lesion development in mice, supporting a role for miRNAs in CNV. The Search strategy and selection criteria section says the studies reviewed used mice or rats, so this source does not substantiate the citing sentence’s reference to studies in humans. Page numbers are unavailable in our copy. (LLM, conf=0.88)

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  • miR-23 was increased in mouse laser-induced choroidal neovascularization models, and suppression of miR-23 reduced choroidal neovascularization development.

    “miR-23 was increased in mouse laser-induced choroidal neovascularization models, and suppression of miR-23 reduced choroidal neovascularization development [46].”

    From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [46]

    The Mouse studies section reports that miR-23a increased in mouse retina/choroid after laser injury. It also reports that an inhibitor targeting both miR-23 and miR-27 reduced CNV area; it does not establish the effect of suppressing miR-23 alone. (LLM, conf=0.85)

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References 89 · Cited by 19

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  1. [1]Afzal A Shaw LC Ljubimov AV Boulton ME Segal MS Grant MB Retinal and choroidal microangiopathies: therapeutic opportunities Microvasc Res 2007 74 131 144 17585951
  2. [2]Agrawal S Chaqour B MicroRNA signature and function in retinal neovascularization World J Biol Chem 2014 5 1 11 24600510 PMC3942538
  3. [3]Aiello LP Pierce EA Foley ED Takagi K Chen H Riddle L Ferrara N King GL Smith LE Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins Proc Natl Acad Sci USA 1995 92 10457 10461 7479819 PMC40630
  4. [4]Al-Latayfeh M Silva PS Sun JK Aiello LP Antiangiogenic therapy for ischemic retinopathies Cold Spring Harb Perspect Med 2012 2 a006411 22675660 PMC3367538
  5. [5]Amin R Puklin JE Frank RN Growth factor localization in choroidal neovascular membranes of age-related macular degeneration Invest Ophthalmol Vis Sci 1994 35 3178 3188 7519180
  6. [6]Askou AL Aagaard L Kostic C Arsenijevic Y Hollensen AK Bek T Jensen TG Mikkelsen JG Corydon TJ Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors Mol Ther Methods Clin Devel 2015 2 14064 26052532 PMC4449022
  7. [7]Askou AL Benckendorff JN Holmgaard A Storm T Aagaard L Bek T Mikkelsen JG Corydon TJ Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs Hum Gene Ther Methods 2017 28 222 233 28817343
  8. [8]Bagga S Bracht J Hunter S Massirer K Holtz J Eachus R Pasquinelli AE Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation Cell 2005 122 553 563 16122423
  9. [9]Baum JL Wise GN Experimental subretinal neovascularization Trans Am Ophthalmol Soc 1965 63 91 107 5859801 PMC1310187
  10. [10]Bhise NS Shmueli RB Sunshine JC Tzeng SY Green JJ Drug delivery strategies for therapeutic angiogenesis and antiangiogenesis Expert Opin Drug Deliv 2011 8 485 504 21338327 PMC3959173
  11. [11]Bora NS Kaliappan S Jha P Xu Q Sohn JH Dhaulakhandi DB Kaplan HJ Bora PS Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization J Immunol 2006 177 1872 1878 16849499
  12. [13]Cai J Yin G Lin B Wang X Liu X Chen X Yan D Shan G Qu J Wu S Roles of NFKB-miR-29s-MMP-2 circuitry in experimental choroidal neovascularization J Neuroinflammation 2014 11 88 24886609 PMC4030271
  13. [14]Cao J Zhao L Li Y Liu Y Xiao W Song Y Luo L Huang D Yancopoulos GD Wiegand SJ Wen R A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap Invest Ophthalmol Vis Sci 2010 51 6009 6017 20538989 PMC3061520
  14. [15]Cao WJ Rosenblat JD Roth NC Kuliszewski MA Matkar PN Rudenko D Liao C Lee PJ Leong-Poi H Therapeutic angiogenesis by ultrasound-mediated microRNA-126-3p delivery Aterioscler Thromb Vasc Biol 2015 35 2401 2411 26381870
  15. [16]Carmeliet P Collen D Tissue factor Int J Biochem Cell Biol 1998 30 661 667 9695023
  16. [17]Chen Y Hu Y Moiseyev G Zhou KK Chen D Ma JX Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency Microvasc Res 2009 78 119 127 19281829 PMC2728019
  17. [18]Dobi ET Puliafito CA Destro M A new model of experimental choroidal neovascularization in the rat Arch Ophthalmol 1989 107 264 269 2464985
  18. [20]Edelman JL Castro MR Quantitative image analysis of laser-induced choroidal neovascularization in rat Exp Eye Res 2000 71 523 533 11040088
  19. [21]elDirini AA Ogden TE Ryan SJ Subretinal endophotocoagulation: a new model of subretinal neovascularization in the rabbit Retina 1991 11 244 249 1925091
  20. [22]Espinosa-Heidmann DG Suner IJ Hernandez EP Monroy D Csaky KG Cousins SW Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization Invest Ophthalmol Vis Sci 2003 44 3586 3592 12882811
  21. [23]Farnoodian M Wang S Dietz J Nickells RW Sorenson CM Sheibani N Negative regulators of angiogenesis: important targets for treatment of exudative AMD Clin Sci (Lond) 2017 131 1763 1780 28679845 PMC6016847
  22. [24]Frykman PK Brown MS Yamamoto T Goldstein JL Herz J Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor Proc Natl Acad Sci U S A 1995 92 8453 8457 7667310 PMC41175
  23. [25]Gao F Sun M Gong Y Wang H Wang Y Hou H MicroRNA-195a-3p inhibits angiogenesis by targeting Mmp2 in murine mesenchymal stem cells Mol Reprod Dev 2016 83 413 423 26989874
  24. [26]Gong Y Li J Sun Y Fu Z Liu CH Evans L Tian K Saba N Fredrick T Morss P Chen J Smith LE Optimization of an image-guided laser-induced choroidal neovascularization model in mice PLoS One 2015 10 e0132643 26161975 PMC4498645
  25. [27]Grossniklaus HE Kang SJ Berglin L Animal models of choroidal and retinal neovascularization Prog Retin Eye Res 2010 29 500 519 20488255 PMC2962694
  26. [28]Hagerman GS Luthert PJ Victor Chong NH Johnson LV Anderson DH Mullins RF An integrated hypothesis that considers drusen as biomarkers of immune- mediated processes at the RPE-Bruch’s membrane interface in aging and age-related macular degeneration Prog Retin Eye Res 2001 20 705 732 11587915
  27. [29]Haines JL Schnetz-Boutaud N Schmidt S Scott WK Agarwal A Postel EA Olson L Kenealy SJ Hauser M Gilbert JR Pericak-Vance MA Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6 Invest Ophthalmol Vis Sci 2006 47 329 335 16384981
  28. [30]He L Hannon GJ MicroRNAs: small RNAs with a big role in gene regulation Nat Rev Genet 2004 5 522 531 15211354
  29. [31]Heckenlively JR Hawes NL Friedlander M Nusinowitz S Hurd R Davisson M Chang B Mouse model of subretinal neovascularization with choroidal anastomosis Retina 2003 23 518 522 12972764
  30. [32]Hou H Gao F Liang H Lv Y Li M Yao L Zhang J Dou G Wang Y MicroRNA- 188-5p regulates contribution of bone marrow-derived cells to choroidal neovascularization development by targeting MMP-2/13 Exp Eye Res 2018 175 115 123 29908885
  31. [33]Hu W Jiang A Liang J Meng H Chang B Gao H Qiao X Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model’s retinal angiomatous proliferation Invest Ophthalmol Vis Sci 2008 49 407 415 18172119
  32. [34]Hua J Guerin KI Chen J Michán S Stahl A Krah NM Seaward MR Dennison RJ Juan AM Hatton CJ Sapieha P Sinclair DA Smith LE Resveratrol inhibits pathologic retinal neovascularization in Vldlr (-/-) mice Invest Ophthalmol Vis Sci 2011 52 2809 2816 21282584 PMC3088563
  33. [35]Ishikawa K Kannan R Hinton DR Molecular mechanisms of subretinal fibrosis in age-related macular degeneration Exp Eye Res 2016 142 19 25 25773985 PMC4568171
  34. [36]Juźwik CA S Drake S Zhang Y Paradis-Isler N Sylvester A Amar-Zifkin A Douglas C Morquette B Moore CS Fournier AE microRNA dysregulation in neurodegenerative diseases: a systematic review Prog Neurobiol 2019 182 101664 31356849
  35. [38]Krystolik MG Afshari MA Adamis AP Gaudreault J Gragoudas ES Michaud NA Li W Connolly E O’Neill CA Miller JW Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment Arch Ophthalmol 2002 120 338 346 11879138
  36. [39]Kvanta A Algvere PV Berglin L Seregard S Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor Invest Ophthalmol Vis Sci 1996 37 1929 1934 8759365
  37. [40]Kwak N Okamoto N Wood JM Campochiaro PA VEGF is major stimulator in model of choroidal neovascularization Invest Ophthalmol Vis Sci 2000 41 3158 3164 10967078
  38. [41]Lambert V Lecomte J Hansen S Blacher S Gonzalez ML Struman I Sounni NE Rozet E de Tullio P Foidart JM Rakic JM Noel A Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice Nat Protoc 2013 8 2197 2211 24136346
  39. [42]Landskroner-Eiger S Moneke I Sessa WC miRNAs as modulators of angiogenesis Cold Spring Harb Perspect Med 2013 3 a006643 23169571 PMC3552340
  40. [43]Li Y Huang D Xia X Wang Z Luo L Wen R CCR3 and choroidal neovascularization PLoS One 2011 6 e17106 21358803 PMC3039674
  41. [44]Liu CH Sun Y Li J Gong Y Tian KT Evans LP Morss PC Fredrick TW Saba NJ Chen J Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization Proc Natl Acad Sci U S A 2015 112 12163 12168 26374840 PMC4593127
  42. [45]Liu CH Wang Z Sun Y Chen J Animal models of ocular angiogenesis: from development to pathologies FASEB J 2017 31 4665 4681 28739642 PMC5636695
  43. [46]Lopez PF Sippy BD Lambert HM Thach AB Hinton DR Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes Invest Ophthalmol Vis Sci 1996 37 855 868 8603870
  44. [47]Lukiw WJ Surjyadipta B Dua P Alexandrov PN Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer’s disease (AD) and in age-related macular degeneration (AMD) Int J Biochem Mol Biol 2012 3 105 116 22509485 PMC3325769
  45. [48]Martinez B Peplow PV MicroRNAs as diagnostic and therapeutic tools for Alzheimer’s disease: advances and limitations Neural Regen Res 2019a 14 242 255 30531004 PMC6301178
  46. [49]Martinez B Peplow PV MicroRNAs as biomarkers of diabetic retinopathy and disease progression Neural Regen Res 2019b 14 1858 1869 31290435 PMC6676865
  47. [50]Martinez B Peplow PV MicroRNAs as diagnostic and prognostic biomarkers of age-related macular degeneration: advances and limitations Neural Regen Res 2020a doi:104103/1673-5374293131 PMC7996036 32985463
  48. [51]Martinez B Peplow PV MicroRNAs in blood and cerebrospinal fluid as diagnostic markers of multiple sclerosis and to monitor disease progression Neural Regen Res 2020b 15 606 619 31638082 PMC6975152
  49. [52]Meister G miRNAs get an early start on translational silencing Cell 2007 131 25 28 17923084
  50. [53]Mens MM Ghanbari M Cell cycle regulation of stem cells by microRNAs Stem Cell Rev Rep 2018 14 309 322 29541978 PMC5960494
  51. [54]Montezuma SR Vavvas D Miller JW Review of the ocular angiogenesis animal models Semin Ophthalmol 2009 24 52 61 19373687
  52. [55]Natoli R Fernando N MicroRNA as therapeutics for age-related macular degeneration Adv Exp Med Biol 2018 1074 37 43 29721925
  53. [56]Neeley KA Gardner TW Ocular neovascularization: clarifying complex interactions Am J Pathol 1998 153 665 670 9736014 PMC1852998
  54. [57]Peng Q Collette W 3rd Giddabasappa A David J Twamley M Kalabat D Aguirre SA Huang W Plasma miR-183/96/182 cluster and miR-124 are promising biomarkers of rat renal toxicity Toxicol Sci 2016 152 273 283 27208084
  55. [58]Pihlmann M Askou AL Aagaard L Bruun GH Svalgaard JD Holm-Nielsen MH Dagnaes-Hansen F Bek T Mikkelsen JG Jensen TG Corydon TJ Adeno- associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo J Gene Med 2012 14 328 338 22438271
  56. [60]Poor SH Qiu Y Fassbender ES Shen S Woolfenden A Delpero A Kim Y Buchanan N Gebuhr TC Hanks SM Meredith EL Jaffee BD Dryja TP Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation Invest Opthalmol Vis Sci 2014 55 6525 6534 25205860
  57. [61]Rakic JM Lambert V Munaut C Bajou K Peyrollier K Alvarez-Gonzalez ML Carmeliet P Foidart JM Noël A Mice without UPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization Invest Ophthalmol Vis Sci 2003 44 1732 1739 12657615
  58. [62]Romano GL Platania CBM Drago F Salomone S Ragusa M Barbagallo C Di Pietro C Purrello M Reibaldi M Avitabile T Longo A Bucolo C Retinal and circulating miRNAs in age-related macular degeneration: An in vivo animal and human study Front Pharmacol 2017 8 168 28424619 PMC5371655
  59. [63]Ruan Q Han S Jiang WG Boulton ME Chen ZJ Law BK Cai J αB-crystallin, an effector of unfolded protein response, confers anti-VEGF resistance to breast cancer via maintenance of intracrine VEGF in endothelial cells Mol Cancer Res 2011 9 1632 1643 21984182 PMC3652269
  60. [64]Ryan SJ The development of an experimental model of subretinal neovascularization in disciform macular degeneration Trans Am Opthalmol Soc 1979 77 707 745 PMC1311723 94717
  61. [65]Sabatel C Malvaux L Bovy N Deroanne C Lambert V Gonzalez ML Colige A Rakic JM Noël A Martial JA Struman I MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells PLoS One 2011 6 e16979 21347332 PMC3037403
  62. [66]Sakurai E Anand A Ambati BK van Rooijen N Ambati J Macrophage depletion inhibits experimental choroidal neovascularization Invest Ophthalmol Vis Sci 2003 44 3578 3585 12882810
  63. [67]Sengupta N Caballero S Mames RN Butler JM Scott EW Grant MB The role of adult bone marrow-derived stem cells in choroidal neovascularization Invest Ophthalmol Vis Sci 2003 44 4908 4913 14578416
  64. [68]Shen D Wen R Tuo J Bojanowski CM Chan CC Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice Ophthalmic Res 2006 38 71 73 16352919 PMC1930147
  65. [69]Shen J Yang X Xie B Chen Y Swaim M Hackett SF Campochiaro PA MicroRNAs regulate ocular neovascularization Mol Ther 2008 16 1208 1216 18500251 PMC3033219
  66. [70]Shi YY Wang YS Zhang ZX Cai Y Zhou J Hou HY van Rooijen N Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells Graefes Arch Clin Exp Ophthalmol 2011 249 1667 1679 21655971
  67. [71]Stahl A Connor KM Sapieha P Chen J Dennison RJ Krah NM Seaward MR Willett KL Aderman CM Guerin KI Hua J Löfqvist C Hellström A Smith LE The mouse retina as an angiogenesis model Invest Opthalmol Vis Sci 2010 51 2813 2826 PMC2891451 20484600
  68. [72]Steen B Sejersen S Berglin L Seregard S Kvanta A Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes Invest Ophthalmol Vis Sci 1998 39 2194 2200 9761302
  69. [73]Stewart MW Rosenfeld PJ Penha FM Wang F Yehoshua Z Bueno-Lopez E Lopez PF Pharmacokinetic rationale for dosing every 2 weeks versus 4 weeks with intravitreal ranibizumab, bevacizumab, and aflibercept (vascular endothelial growth factor Trap-eye) Retina 2012 32 434 457 22374154
  70. [74]Takahashi T Nakamura T Hayashi A Kamei M Nakabayashi M Okada AA Tomita N Kaneda Y Tano Y Inhibition of experimental choroidal neovascularization by overexpression of tissue inhibitor of metalloproteinase-3 in retinal pigment epithelium cells Am J Ophthalmol 2000 130 774 781 11124297
  71. [75]Tobe T Ortega S Luna JD Ozaki H Okamoto N Derevjanik NL Vinores SA Basilico C Campochiaro PA Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model Am J Pathol 1998 153 1641 1646 9811357 PMC1853405
  72. [76]Toma HS Barnett JM Penn JS Kim SJ Improved assessment of laser-induced choroidal neovascularization Microvasc Res 2010 80 295 302 20553963 PMC3390000
  73. [77]Wang L Lee AY Wigg JP Peshavariya H Liu P Zhang H miRNA involvement in angiogenesis in age-related macular degeneration J Physiol Biochem 2016a 72 583 592 27349759
  74. [78]Wang L Lee AY Wigg JP Peshavariya H Liu P Zhang H miR-126 regulation of angiogenesis in age-related macular degeneration in CNV mouse model Int J Mol Sci 2016b 17 895 PMC4926429 27338342
  75. [79]Wang S Koster KM He Y Zhou Q miRNAs as potential therapeutic targets of age-related macular degeneration Future Med Chem 2012 4 277 287 22393936 PMC3313592
  76. [80]Witmer AN Vrensen GF Van Noorden CJ Schlingemann RO Vascular endothelial growth factors and angiogenesis in eye disease Prog Retin Eye Res 2003 22 1 29 12597922
  77. [81]Yan XC Cao J Liang L Wang L Gao F Yang ZY Duan JL Chang TF Deng SM Liu Y Dou GR Zhang J Zheng QJ Zhang P Han H miR-342-5p is a Notch downstream molecule and regulates multiple angiogenic pathways including Notch, vascular endothelial growth factor and transforming growth factor β signaling J Am Heart Assoc 2016 5 e003042 26857067 PMC4802463
  78. [82]Yanagi Y Tamaki Y Obata R Muranaka K Homma N Matsuoka H Mano H Subconjunctival administration of bucillamine suppresses choroidal neovascularization in the rat Invest Ophthalmol Vis Sci 2002 43 3495 3499 12407161
  79. [83]Zhang P Wang H Luo X Liu H Lu B Li T Yang S Gu Q Li B Wang F Sun X MicroRNA-155 inhibits polarization of macrophages to M2-type and suppresses choroidal neovascularization Inflammation 2018 41 143 153 28965281
  80. [84]Zhao S Lu L Liu Q Chen J Yuan Q Qiu S Wang X MiR-505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B Scand J Immunol 2019 90 e12832 31544253
  81. [85]Zhou J Pham L Zhang N He S Gamulescu MA Spee C Ryan SJ Hinton DR Neutrophils promote experimental choroidal neovascularization Mol Vis 2005 11 414 424 15988410
  82. [86]Zhou Q Gallagher R Ufret-Vincenty R Li X Olson EN Wang S Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23-27-24 clusters Proc Natl Acad Sci U S A 2011 108 8287 8292 21536891 PMC3100947
  83. [87]Zhou Q Anderson C Zhang H Li X Inglis F Jayagopal A Wang S Repression of choroidal neovascularization through actin cytoskeleton pathways by microRNA-24 Mol Ther 2014 22 378 389 24297048 PMC3916039
  84. [88]Zhou Q Anderson C Hanus J Zhao F Ma J Yoshimura A Wang S Strand and cell type-specific function of microRNA-126 in angiogenesis Mol Ther 2016 24 1823 1835 27203443 PMC5112035
  85. [89]Zhu Y Lu Q Shen J Zhang L Gao Y Shen X Xie B Improvement and optimization of standards for a preclinical animal test model of laser induced choroidal neovascularization PLoS One 2014 9 e94743 24781648 PMC4004536
  86. [90]Zhuang Z Xiao-qin Hu H Tian SY Lu ZJ Zhang TZ Bai YL Down-regulation of microRNA-155 attenuates retinal neovascularization via the PI3K/Akt pathway Mol Vis 2015 21 1173 1184 26539029 PMC4605754

Authors
Peplow, P., & Martinez, B.
Affiliations
  • University of Otago (NZ)
  • St. George's University (GD)
Corresponding author
Peplow, PhilipV
ORCID
Martinez, Bridget
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021
Volume
16
Issue
4
Pages
621
ISSN
1673-5374 (ISSN-L)
DOI
10.4103/1673-5374.295271
PMC
PMC8067925
OpenAlex
W3092207638
Cited by
19
References
89
Citations by year
2026: 5 · 2025: 3 · 2024: 6 · 2022: 3 · 2021: 2
FWCI
0.99
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
choroidal neovascularization, microRNA, laser-induced choroidal neovascularization, neovascular age-related macular degeneration, miRNA expression profiling, retinal pigment epithelium, choroid, angiogenesis, inflammation, miRNA mimics and inhibitors, therapeutic target, miR-155, miR-126-3p, miR-342-5p, miR-505, vascular endothelial growth factor

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