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Cited by 41Extracellular vesicles in diseaseAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Extracellular vesicles in Alzheimer’s disease: from pathology to therapeutic approaches

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Thakor, AvneshS, Garcia-Contreras, Marta·2023·Neural Regeneration Research
DOI 10.4103/1673-5374.343882PMC PMC9241420
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Abstract

Alzheimer's disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive symptoms. Identifying novel biomarkers for Alzheimer's disease has the potential for patient risk stratification, early diagnosis, and disease monitoring in response to therapy. A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific diseases. In addition, extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic cargo. This is critical given the huge unmet need for novel treatment strategies for Alzheimer's disease. This review summarizes and discusses the most recent findings in this field.

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  • Several studies have shown that both extracellular free Aβ and Aβ-contained EVs play a role in the progression of AD pathology.

    “Several studies have shown that both extracellular free Aβ and Aβ-contained EVs play a role in the progression of AD pathology [136–140].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [136]

    The section “Extracellular Vesicles in the Pathogenesis of Alzheimer’s Disease” reports that Aβ-containing EVs are toxic to neurons and can stimulate Aβ aggregation, supporting their role in AD pathology. It also describes Aβ accumulation and plaque formation, but does not specifically identify extracellular free Aβ, as distinct from EV-associated Aβ, as contributing to progression. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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References 58 · Cited by 41

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Authors
Thakor, A., & Garcia-Contreras, M.
Affiliations
Stanford University (US)
Corresponding author
Thakor, AvneshS
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2023
Volume
18
Issue
1
Pages
18
ISSN
1673-5374 (ISSN-L)
DOI
10.4103/1673-5374.343882
PMC
PMC9241420
OpenAlex
W4284960943
Cited by
41
References
58
Citations by year
2026: 9 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 1
FWCI
0.83
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
extracellular vesicles, Alzheimer's disease, biomarkers, early diagnosis, treatment delivery, biologic therapy, neurodegeneration, disease pathology

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