Intraductal papillary mucinous neoplasm of pancreas

Machado, NormanOneil; al Qadhi, Hani; al Wahibi, Khalifa

doi:10.4103/1947-2714.157477

Cited by 149Pancreatic and Hepatic Oncology ResearchNeuroendocrine Tumor Research AdvancesPancreatitis Pathology and Treatment

Intraductal papillary mucinous neoplasm of pancreas

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Machado, NormanOneil, al Qadhi, Hani, al Wahibi, Khalifa·2015·North American Journal of Medical Sciences

DOI 10.4103/1947-2714.157477PMC PMC4462811

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Abstract

Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are neoplasms that are characterized by ductal dilation, intraductal papillary growth, and thick mucus secretion. This relatively recently defined pathology is evolving in terms of its etiopathogenesis, clinical features, diagnosis, management, and treatment guidelines. A PubMed database search was performed. All the relevant abstracts in English language were reviewed and the articles in which cases of IPMN could be identified were further scrutinized. Information of IPMN was derived, and duplication of information in several articles and those with areas of persisting uncertainties were excluded. The recent consensus guidelines were examined. The reported incidence of malignancy varies from 57% to 92% in the main duct-IPMN (MD-IPMN) and from 6% to 46% in the branch duct-IPMN (BD-IPMN). The features of high-risk malignant lesions that raise concern include obstructive jaundice in a patient with a cystic lesion in the pancreatic head, the findings on radiological imaging of a mass lesion of >30 mm, enhanced solid component, and the main pancreatic duct (MPD) of size ≥10 mm; while duct size 5-9 mm and cyst size <3 mm are considered as "worrisome features." Magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) are primary investigations in diagnosing and following up on these patients. The role of pancreatoscopy and the analysis of aspirated cystic fluid for cytology and DNA analysis is still to be established. In general, resection is recommended for most MD-IPMN, mixed variant, and symptomatic BD-IPMN. The 5-year survival of patients after surgical resection for noninvasive IPMN is reported to be at 77-100%, while for those with invasive carcinoma, it is significantly lower at 27-60%. The follow-up of these patients could vary from 6 months to 1 year and would depend on the risk stratification for invasive malignancy and the pathology of the resected specimen. The understanding of IPMN has evolved over the years. The recent guidelines have played a role in this regard.

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Rates of malignancy in IPMNs range from 57 to 92% for MD-IPMN and 6 to 46% for BD-IPMNs.
“While the rates of malignancy in IPMNs is well characterized (ranging from 57 to 92% for MD-IPMN and 6 to 46% for BD-IPMNs), few reliable tools exist for predicting the risk of an individual lesion progressing to carcinoma [49].”
From Artificial Intelligence in the Diagnosis and Treatment of Pancreatic Cystic Lesions and Adenocarcinoma (2023) · cites this paper as [49]
Few reliable tools exist for predicting the risk of an individual IPMN lesion progressing to carcinoma.
“While the rates of malignancy in IPMNs is well characterized (ranging from 57 to 92% for MD-IPMN and 6 to 46% for BD-IPMNs), few reliable tools exist for predicting the risk of an individual lesion progressing to carcinoma [49].”
From Artificial Intelligence in the Diagnosis and Treatment of Pancreatic Cystic Lesions and Adenocarcinoma (2023) · cites this paper as [49]

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International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354 · cited 10× · see citing works
“The following CT scan signs are useful in differentiating a benign IPMN from a malignant IPMN: [2,3,10,16] 1) the presence or absence of mural nodules, 2) focal size of the lesion: A lesion greater than 30 mm, with mural nodules that strongly suggest malignancy, 3) enlargement and metastasis of the…”
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“[3,4,13,26,29] However, a signi ﬁ cant number of patients with inactive mucin production or involvement of the body/tail of the pancreas may be asymptomatic.”
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“[50] Association with other malignancies An interesting observation made by some researchers is the likely association of IPMN with synchronous or metachronous malignancy in various other organs.”
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Chari, S., Yadav, D., Smyrk, T., Dimagno, E., Miller, L., Raimondo, M., Clain, J., Norton, I., Pearson, R., Petersen, B., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.36552 · Cited by 499 · cited 1× · see citing works
“[25,26,60,93] There is no good long-term data to indicate whether surveillance can be safely spaced to every 2 years or even discontinued after long-term stability.”
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Del Chiaro, M., Verbeke, C., Salvia, R., Klöppel, G., Werner, J., McKay, C., Friess, H., Manfredi, R., Van Cutsem, E., Löhr, M., et al. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.01.010 · Cited by 498 · see citing works
Pathologically and Biologically Distinct Types of Epithelium in Intraductal Papillary Mucinous Neoplasms: Delineation of an “Intestinal” Pathway of Carcinogenesis in the Pancreas
Adsay, N., Merati, K., Basturk, O., Iacobuzio-Donahue, C., Levi, E., Cheng, J. D., Sarkar, F. H., Hruban, R., & Klimstra, D. (2004) · American Journal of Surgical Pathology · doi:10.1097/00000478-200407000-00001 · Cited by 460 · cited 1× · see citing works
“[51,52] Oncocytic type is another variant and is characterized by complex aborising papillae with delicate cores, oncocytic cells, intraepithelial lumina formation, and common mucin 6 (MUC6) expression.”
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Khalid, A., Zahid, M., Finkelstein, S., Leblanc, J., Kaushık, N., Ahmad, N., Brugge, W., Edmundowicz, S., Hawes, R., & Mcgrath, K. (2009) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2008.07.033 · Cited by 449 · cited 1× · see citing works
“Studies show that the detection of KRAS mutation is likely to support the diagnosis of mucinous cyst more accurately rather than malignant cyst.[91,92] A recent study indicates that GNAS mutation may be helpful in distinguishing a mucinous cyst from an indolent cyst that can be managed conservatively.”
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“[17,43,80] The management of the ductal resection margin with benign and noninvasive diseases such as the various degrees of atypia or dysplasia is a controversial issue.[43,81] In general, the presence of lesser grades of dysplasia (moderate or low-grade) may not require any further therapy.”
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Brat, D. J., Lillemoe, K. D., Yeo, C. J., Warfield, P. B., & Hruban, R. H. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199802000-00003 · Cited by 309 · see citing works
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Cizginer, S., Turner, B. G., Bilge, A., Karaca, Ç., Pitman, M., & Brugge, W. (2011) · Pancreas · doi:10.1097/mpa.0b013e31821bd62f · Cited by 305 · cited 5× · see citing works
“[60] If expertise is available, consideration is given for EUS with cytopathology,[62-69] CEA,[39] and molecular analysis.”
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Gan, S., Thompson, C., Lauwers, G. Y., Bounds, B., & Brugge, W. (2005) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(05)00320-2 · Cited by 303 · see citing works
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients
Sessa, F., Solcia, E., Capella, C., Bonato, M., Scarpa, A., Zamboni, G., Pellegata, N., Ranzani, G., Rickaert, F., & Klöppel, G. (2004) · Virchows Archiv · doi:10.1007/bf00189573 · Cited by 301 · cited 4× · see citing works
“a special entity among the pancreatic neoplasms.[22] The”
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“[52,54] The gastric type is typically of low grade, with only a small percentage developing into carcinoma [Figure 1].”
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“[63,64] PanIN is generally less than 0.5 cm while IPMN is over 1 cm. [63,64] ITPN is a rare lesion and is characterized by a more solid intraductal growth without visible mucin secretion and with less cystic features than IPMN.”
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“[88] In addition, recent studies have shown that PDAC occurs quite frequently as a malignant transformation of IPMN in some sites, and not related to IPMN at others.”
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“[57] It is regarded by some as a high-grade version of the gastric type.”
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“[2] , 25 , 33, 82,”
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“84-86] The patients suitable for these include those with cystic lesions that show no communication with the MPD and IPMN in those who refuse surgery or are high-risk surgical candidates.”
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“[86,87] While signifi cant success has been reported in patients with CT-defi ned cyst resolution (33-79%), concerns remain.[84-87] These include insuffi cient ethanol infi ltration and impossible imaging surveillance after cyst collapse.”
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Taouli, B., Vilgrain, V., Vullierme, M., Terris, B., Denys, A., Sauvanet, A., Hammel, P., & Menu, Y. (2000) · Radiology · doi:10.1148/radiology.217.3.r00dc24757 · Cited by 163 · cited 3× · see citing works
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White, R., D'Angelica, M., Katabi, N., Tang, L. H., Klimstra, D., Fong, Y., Brennan, M., & Allen, P. (2007) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2006.12.040 · Cited by 160 · cited 1× · see citing works
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“1-6,13 , 25-32 25-32] Surgical specimen of BD-IPMN BD-IPMN, when histologically”
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Weinberg, B. M., Spiegel, B., Tomlinson, J., & Farrell, J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.10.001 · Cited by 114 · cited 1× · see citing works
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“[2,31,60] The follow-up would include history/ physical examination, MRI/MRCP (or pancreatic CT scan) surveillance, [1-6, 12-14 12-14, 17 ,”
Influential
Intraductal papillary-mucinous tumors of the pancreas: Differential diagnosis between benign and malignant tumors by endoscopic ultrasonography
Kubo, H., Chijiiwa, Y., Akahoshi, K., Hamada, S., Harada, N., Sumii, T., Takashima, M., & Nawata, H. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03794.x · Cited by 109 · see citing works
Intraductal papillary mucinous neoplasm of the pancreas: can benign lesions be differentiated from malignant lesions with multidetector CT?
Kawamoto, S., Horton, K., Lawler, L., Hruban, R., & Fishman, E. (2005) · Radiographics · doi:10.1148/rg.256055036 · Cited by 107
Frozen Sectioning of the Pancreatic Cut Surface During Resection of Intraductal Papillary Mucinous Neoplasms of the Pancreas Is Useful and Reliable: A Prospective Evaluation
Couvelard, A., Sauvanet, A., Kianmanesh, R., Hammel, P., Colnot, N., Lévy, P., Ruszniewski, P., Bedossa, P., & Belghiti, J. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000188459.99624.a2 · Cited by 106 · cited 1× · see citing works
“[2,60] This is despite the concern that the diagnosis by frozen section is not always accurate as it is considered a suboptimal method of analyzing tissue morphology.[79] The resection should be extended if the ductal margin shows malignant invasive disease.”
Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasms.
Wiesenauer, C., Schmidt, C., Cummings, O., Yiannoutsos, C., Howard, T., Wiebke, E., Goulet, R., Mchenry, L., Sherman, S., Lehman, G., et al. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.6.610 · Cited by 103 · cited 1× · see citing works
“13, 16, 26, 29, 33, 35, 41, 46] The most likely among”
Intraductal papillary mucinous neoplasms of the pancreas.
Gourgiotis, S., Ridolfini, M. P., & Germanos, S. (2007) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2006.11.031 · Cited by 102
Histopathological Diagnosis of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary-Mucinous Neoplasms: Interobserver Agreement
Longnecker, D. S., Adsay, V. N., Castillo, C. F. F.-D., Hruban, R. H., Kasugai, T., Klimstra, D. S., Kl??ppel, G., L�ttges, J., Memoli, V. A., Tosteson, T. D., et al. (2005) · Pancreas · doi:10.1097/01.mpa.0000186245.35716.18 · Cited by 102 · cited 2× · see citing works
“[63,64] PanIN is generally less than 0.5 cm while IPMN is over 1 cm. [63,64] ITPN is a rare lesion and is characterized by a more solid intraductal growth without visible mucin secretion and with less cystic features than IPMN.”
Influential
Frequency of Extrapancreatic Neoplasms in Intraductal Papillary Mucinous Neoplasm of the Pancreas: Implications for Management
Reid-Lombardo, K., Mathis, K., Wood, C. M., Harmsen, W., & Sarr, M. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181b5ad1e · Cited by 100 · cited 5× · see citing works
“[48] Increased age, heavy cigarette smoking, alcohol consumption, and ﬁ rst degree family history of gastric cancer were seen as the signi ﬁ cant risk factors while ﬁ rst degree family history of colorectal cancer was a borderline risk factor.”
Influential
Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type.
Sadakari, Y., Ohuchida, K., Nakata, K., Ohtsuka, T., Aishima, S., Takahata, S., Nakamura, M., Mizumoto, K., & Tanaka, M. (2010) · Surgery · doi:10.1016/j.surg.2009.11.011 · Cited by 99 · cited 5× · see citing works
“[52,53] Although carcinoma may develop in them, it is usually of tubular type and behaves more like the conventional pancreatic ductal adenocarcinoma (PDAC).”
Influential
Septated cystic tumors of the pancreas: Is it possible to treat them by endoscopic ultrasonography-guided intervention?
Oh, H.-C., Seo, D., Kim, S.-C., Yu, E., Kim, K., Moon, S.-H., Park, D., Lee, S.-S., Lee, S.-K., & Kim, M.-H. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802495537 · Cited by 97 · cited 1× · see citing works
“[86,87] 84-87] These include insuf ﬁ cient ethanol in ﬁ ltration and impossible imaging surveillance after cyst collapse.”
Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas.
Castellano-Megías, V., Andrés, C., López-Alonso, G., & Colina‐Ruizdelgado, F. (2014) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v6.i9.311 · Cited by 96 · cited 8× · see citing works
“…stula may occur as a consequence of mechanical penetration as a result of excessive pressure by the mucin-ﬁ lled ducts or due to in ﬂ ammation or autodigestion by the enzyme-rich ﬂ uids, [27] or it could be a result of direct invasion due to malignancy, as in malignant IPMN (high-grade dysplasia).”
Influential
Intraductal papillary mucinous neoplasm.
Reis, J., Schiffman, S. R., & Voci, S. L. (2012) · Ultrasound Quarterly · doi:10.1097/ruq.0b013e318258602f · Cited by 94
Surgical management of intraductal papillary mucinous tumors of the pancreas: the role of routine frozen section of the surgical margin, intraoperative endoscopic staged biopsies of the Wirsung duct, and pancreaticogastric anastomosis.
Gigot, J., Deprez, P., Sempoux, C., Descamps, C., Métairie, S., Glineur, D., & Gianello, P. (2001) · Archives of Surgery · doi:10.1001/archsurg.136.11.1256 · Cited by 84 · cited 1× · see citing works
“[60] It has been suggested that pancreaticogastrostomy should be used after pancreaticoduodenectomy that would allow easy access to the pancreatic duct and thus, for disease surveillance with endoscopy and sampling of the pancreatic juice for cytology.[94]”
Diagnostic yield of EUS-FNA-based cytology distinguishing malignant and benign IPMNs: A systematic review and meta-analysis
Suzuki, R., Thosani, N., Annangi, S., Guha, S., & Bhutani, M. S. (2014) · Pancreatology · doi:10.1016/j.pan.2014.07.006 · Cited by 84 · cited 2× · see citing works
“[60] If expertise is available, consideration is given for EUS with cytopathology,[62-69] CEA,[39] and molecular analysis.”
Interleukin-6 dependence of advanced malignant plasma cell dyscrasias
Zhang, X., Bataille, R., Widjenes, J., & Klein, B. (1992) · Cancer · doi:10.1002/1097-0142(19920315)69:6 · Cited by 83 · see citing works
Single-operator pancreatoscopy is helpful in the evaluation of suspected intraductal papillary mucinous neoplasms (IPMN).
Arnelo, U., Siiki, A., Swahn, F., Segersvärd, R., Enochsson, L., del Chiaro, M., Lundell, L., Verbeke, C., & Löhr, J. (2014) · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · doi:10.1016/j.pan.2014.08.007 · Cited by 78 · see citing works
Distinguishing Benign From Malignant Intraductal Papillary Mucinous Tumors of the Pancreas by Imaging Techniques
Baba, T., Yamaguchi, T., Ishihara, T., Kobayashi, A., Oshima, T., Sakaue, N., Kato, K., Ebara, M., & Saisho, H. (2004) · Pancreas · doi:10.1097/00006676-200410000-00006 · Cited by 71 · cited 3×
“13, 16, 30, 46] The MPD is”
Added value of diffusion‐weighted imaging to MR cholangiopancreatography with unenhanced mr imaging for predicting malignancy or invasiveness of intraductal papillary mucinous neoplasm of the pancreas
Kang, K. M., Lee, J. M., Shin, C.-I., Baek, J., Kim, S. H., Yoon, J., Han, J., & Choi, B. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24022 · Cited by 69 · cited 4×
“[60] MRCP is reported to be more sensitive than ERCP, [2,3,9,12,13,60] the distinct advantage being that it is not operator dependent and noninvasive.”
Influential
Systematic Review and Meta-Analysis Comparing the Surgical Outcomes of Invasive Intraductal Papillary Mucinous Neoplasms and Conventional Pancreatic Ductal Adenocarcinoma
Koh, Y., Chok, A., Zheng, H.-L., Tan, C. S., & Goh, B. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3639-0 · Cited by 67 · cited 3×
“[60] If expertise is available, consideration is given for EUS with cytopathology,[62-69] CEA,[39] and molecular analysis.[89,90] However, molecular analysis is evolving.”
Influential
International Consensus Guidelines parameters for the prediction of malignancy in intraductal papillary mucinous neoplasm are not properly weighted and are not cumulative
Roch, A. M., Ceppa, E. P., DeWitt, J. M., Al‐Haddad, M., House, M. G., Nakeeb, A., & Schmidt, C. M. (2014) · HPB · doi:10.1111/hpb.12305 · Cited by 66 · cited 11× · see citing works
“[63,64] PanIN is generally less than 0.5 cm while IPMN is over 1 cm. [63,64] ITPN is a rare lesion and is characterized by a more solid intraductal growth without visible mucin secretion and with less cystic features than IPMN.”
Influential
Pancreatic Juice Cytology and Subclassification of Intraductal Papillary Mucinous Neoplasms of the Pancreas
Hibi, Y., Fukushima, N., Tsuchida, A., Sofuni, A., Itoi, T., Moriyasu, F., Mukai, K., & Aoki, T. (2007) · Pancreas · doi:10.1097/mpa.0b013e31802dea0 · Cited by 60 · cited 1× · see citing works
“[56] Differential diagnoses of IPMN that should be histopathologically differentiated include other mucinous cystic lesions, retention cysts, pancreatic intraepithelial neoplasm (PanIN), and intraductal tubulopapillary neoplasm (ITPN).”
The Natural History of Main Duct–Involved, Mixed-Type Intraductal Papillary Mucinous Neoplasm: Parameters Predictive of Progression
Roch, A., Ceppa, E., Al-Haddad, M., Dewitt, J. M., House, M. G., Zyromski, N., Nakeeb, A., & Schmidt, C. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000927 · Cited by 59 · cited 3× · see citing works
“[2,31,60] The follow-up would include history/ physical examination, MRI/MRCP (or pancreatic CT scan) surveillance, [1-6, 12-14 12-14, 17 ,”
Additional value of FDG PET/CT to contrast-enhanced CT in the differentiation between benign and malignant intraductal papillary mucinous neoplasms of the pancreas with mural nodules
Takanami, K., Hiraide, T., Tsuda, M., Nakamura, Y., Kaneta, T., Takase, K., Fukuda, H., & Takahashi, S. (2011) · Annals of Nuclear Medicine · doi:10.1007/s12149-011-0494-y · Cited by 58
Intraoperative ultrasonography by high-resolution annular array transducer for intraductal papillary mucinous tumors of the pancreas.
Kaneko, T., Nakao, A., Inoue, S., Sugimoto, H., Hatsuno, T., Ito, A., Hirooka, Y., Nagasaka, T., & Nakashima, N. (2001) · Surgery · doi:10.1067/msy.2001.109118 · Cited by 58 · cited 1×
“[2-5,13,26,29,33] The various options employed by the surgeon to determine the extent of disease and facilitate the extent of resection include intraoperative ultrasonography[77,78] and pancreatoscopy.”
Intraductal Oncocytic Papillary Neoplasms of the Pancreas.
Kallen, M., & Naini, B. (2016) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2014-0595-rs · Cited by 54 · cited 1× · see citing works
“[55] These lesions are uncommon and have limited invasion capability and tend to be large with obscure intraductal appearance.”
Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography.
Inoue, K., Ohuchida, J., Ohtsuka, T., Nabae, T., Yokohata, K., Ogawa, Y., Yamaguchi, K., & Tanaka, M. (2003) · Gastrointestinal Endoscopy · doi:10.1067/s0016-5107(03)01962-x · Cited by 54 · cited 2×
“[35] 34-36] However, due to its invasive nature, of late it has been superseded by MRCP as an initial investigation of choice and is used only in those patients with uncertain diagnosis.”
Prevalence and risk factors of extrapancreatic malignancies in a large cohort of patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas.
Larghi, A., Panic, N., Capurso, G., Leoncini, E., Arzani, D., Salvia, R., del Chiaro, M., Frulloni, L., Arcidiacono, P., Zerbi, A., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt184 · Cited by 51 · see citing works
Pseudomyxoma Peritonei Accompanied by Intraductal Papillary Mucinous Neoplasm of the Pancreas
Mizuta, Y., Akazawa, Y., Shiozawa, K., Ohara, H., Ohba, K., Ohnita, K., Isomoto, H., Takeshima, F., Omagari, K., Tanaka, K., et al. (2005) · Pancreatology (Print) · doi:10.1159/000086551 · Cited by 49 · cited 1× · see citing works
“In addition, the risk of developing pancreatic fi stulae and recurrence from potential residual neoplasms exists.[74]”
Adjuvant chemotherapy seems beneficial for invasive intraductal papillary mucinous neoplasms.
Caponi, S., Vasile, E., Funel, N., Lio, N. D., Campani, D., Ginocchi, L., Lucchesi, M., Caparello, C., Lencioni, M., Cappelli, C., et al. (2013) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2012.12.005 · Cited by 48 · cited 2× · see citing works
“[7] Signi ﬁ cant disease-free survival bene ﬁ t was seen in both node positive and node negative subgroups, with signi ﬁ cant overall survival bene ﬁ t in patients with node involvement.”
The evolution of endoscopic ultrasound: improved imaging, higher accuracy for fine needle aspiration and the reality of endoscopic ultrasound-guided interventions
Hawes, R. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32833d1799 · Cited by 45 · see citing works
Laparoscopic vs. Open Resection of Noninvasive Intraductal Pancreatic Mucinous Neoplasms
GUMBS, A., Grès, P., Madureira, F. A. V., & Gayet, B. (2008) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-007-0311-z · Cited by 44 · cited 2× · see citing works
“[75,76] However, conversion to a standard resection with lymphadenectomy is carried out if intraoperative ﬁ ndings raise concern of malignancy or frozen section pathology reveals high-grade dysplasia or invasive disease.”
Pancreatic Resection Guided by Preoperative Intraductal Ultrasonography for Intraductal Papillary Mucinous Neoplasm
Cheon, Y., Cho, Y., Jeon, S., Moon, J., Jeong, S., Hur, K., Jin, S.-Y., & Lee, J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.169 · Cited by 40 · cited 1× · see citing works
“[2-5,13,26,29,33] The various options employed by the surgeon to determine the extent of disease and facilitate the extent of resection include intraoperative ultrasonography[77,78] and pancreatoscopy.”
Overview of the clinical problem: facts and current issues of mucinous cystic neoplasms of the pancreas.
Jeurnink, S., Vleggaar, F., & Siersema, P. (2008) · Digestive and Liver Disease · doi:10.1016/j.dld.2008.03.018 · Cited by 39 · cited 10×
“[3,4,13,26,29] However, a signi ﬁ cant number of patients with inactive mucin production or involvement of the body/tail of the pancreas may be asymptomatic.”
Influential
Fate of the pancreatic remnant after resection for an intraductal papillary mucinous neoplasm: a longitudinal level II cohort study.
Moriya, T., & Traverso, W. (2011) · Archives of Surgery · doi:10.1001/archsurg.2011.2276 · Cited by 32 · cited 1× · see citing works
“[2,31,60] The follow-up would include history/ physical examination, MRI/MRCP (or pancreatic CT scan) surveillance, [1-6, 12-14 12-14, 17 ,”
Proper management and follow-up strategy of branch duct intraductal papillary mucinous neoplasms of the pancreas.
Bae, S., Lee, K. T., Lee, J.-H., Lee, J., Lee, K., & Rhee, J. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.09.010 · Cited by 31 · cited 5× · see citing works
“[2,31,60] The follow-up would include history/ physical examination, MRI/MRCP (or pancreatic CT scan) surveillance, [1-6, 12-14 12-14, 17 ,”
Influential
High Expression of Intestinal-Type Mucin (MUC2) in Intraductal Papillary Mucinous Neoplasms Coexisting With Extrapancreatic Gastrointestinal Cancers
Lee, S.-Y., Choi, D., Jang, K., Lee, K. T., Choi, S., Heo, J., Lee, J., Paik, S., & Rhee, J. (2006) · Pancreas · doi:10.1097/01.mpa.0000202939.40213.fd · Cited by 30 · cited 1× · see citing works
“[49] There are no screening recommendations for detecting extrapancreatic malignancies at present, but it is prudent to look for these lesions based on the frequency of malignancies in the general population of the country or region.”
Pancreatic intraductal papillary mucinous neoplasms: role of CT in predicting pathologic subtypes.
Gupta, R., Mortelé, K., Tatli, S., Girshman, J., Glickman, J., Levy, A., Erturk, S. M., Heffess, C., Banks, P., & Silverman, S. (2008) · AJR. American journal of roentgenology · doi:10.2214/ajr.07.3302 · Cited by 28
Multifocal branch-duct intraductal papillary mucinous neoplasms (IPMNs) of the pancreas: magnetic resonance (MR) imaging pattern and evolution over time
Castelli, F., Bosetti, D., Negrelli, R., Paola, V. D., Zantedeschi, L., Ventriglia, A., Manfredi, R., & Mucelli, R. P. (2013) · La radiologia medica · doi:10.1007/s11547-013-0945-8 · Cited by 27 · cited 5×
“[9,14,18,23] , The type one”
Influential
Outcomes of intraductal papillary mucinous neoplasm with "Sendai-positive" criteria for resection undergoing non-operative management.
Piciucchi, M., Crippa, S., del Chiaro, M., Valente, R., Pezzilli, R., Falconi, M., Fave, G. D., & Capurso, G. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.01.016 · Cited by 24 · cited 1× · see citing works
“In general, pancreaticoduodenectomy with lymphadenectomy is indicated for invasive MD-IPMN of the head, the neck, or the uncinate process, [1-6, 13-15 13-15, 25, 26, 33] and distal pancreatectomy is indicated for IPMN of the body and tail”
Prediction of Malignancy With Endoscopic Ultrasonography in Patients With Branch Duct–Type Intraductal Papillary Mucinous Neoplasm
Lee, K., Lee, S., Lee, J., Ryu, J., Kim, E. Y., Kim, T. H., Moon, J., Lee, W.-J., Cho, Y., & Kim, J. J. (2014) · Pancreas · doi:10.1097/mpa.0000000000000177 · Cited by 22 · cited 2× · see citing works
“[37,66] EUS is generally considered to be reliable in identifying lesions that merit resection than in clarifying the exact type of cystic lesion present.”
Familial intraductal papillary mucinous neoplasms of the pancreas
Rebours, V., Couvelard, A., Peyroux, J.-L., Sauvanet, A., Hammel, P. R., Ruszniewski, P. B., & Lévy, P. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.07.003 · Cited by 21 · cited 1× · see citing works
“[9,14,18,23] , The type one”
Correlation between CT patterns and pathological classification of intraductal papillary mucinous neoplasm.
Zhang, J., Wang, P., & Yuan, X.-D. (2010) · European Journal of Radiology · doi:10.1016/j.ejrad.2008.09.035 · Cited by 17 · cited 2×
“[60] 9, 10, 12 , 13,16 , diagnosis is most likely.”
The Utilization of Imaging Features in the Management of Intraductal Papillary Mucinous Neoplasms
Palmucci, S., Trombatore, C., Foti, P., Mauro, L., Milone, P., Milazzotto, R., Latino, R., Bonanno, G., Petrillo, G., & Cataldo, A. D. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/765451 · Cited by 11 · cited 8×
“Several other fi ndings suggestive of malignancy include large side branch tumors, papillary bulging, CBD dilatation, large number of tumors, solid components, calcifi ed ductal content, invasion to adjacent organs, enlarged peripancreatic lymph nodes, and presence of liver lesions that are suggestive of metastasis.[2…”
Influential

Flagged first, then by citations

8 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

[11]Inoue H Tsuchida A Kawasaki Y Fujimoto Y Yamasaki S Kajiyama G Preoperative diagnosis of intraductal papillary-mucinous tumors of the pancreas with attention to telomerase activity Cancer 2001 91 35 41 11148557
[19]Furuta K Watanabe H Ikeda S Differences between solid and duct-ectatic types of pancreatic ductal carcinomas Cancer 1992 69 1327 33 1540869
[29]Longnecker DS Observations on the etiology and pathogenesis of intraductal papillary-mucinous neoplasms of the pancreas Hepatogastroenterology 1998 45 1973 80 9951850
[36]Maeshiro K Nakayama Y Yasunami Y Furuta K Ikeda S Diagnosis of mucin-producing tumour of the pancreas by balloon-catheter endoscopic retrograde pancreatography - compression study Hepatogastroenterology 1998 45 1986 95 9951852
[73]Takeyoshi I Ohwada S Nakamura S Ogawa T Kawashima Y Ikeya T Segmental pancreatectomy for mucin-producing pancreatic tumors Hepatogastroenterology 1999 46 2585 8 10522046

Sorted by citations

Burden of Pancreatic Cancer: From Epidemiology to Practice
Khalaf, N., El-Serag, H. B., Abrams, H. R., & Thrift, A. P. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.02.054 · Cited by 308 · see citing works
Enrichment of oral microbiota in early cystic precursors to invasive pancreatic cancer
Gaiser, R. A., Halimi, A., Alkharaan, H., Lu, L., Davanian, H., Healy, K., Hugerth, L. W., Ateeb, Z., Valente, R., Fernández Moro, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317458 · Cited by 227 · see citing works
Predicting pancreatic ductal adenocarcinoma using artificial intelligence analysis of pre-diagnostic computed tomography images.
Qureshi, T. A., Gaddam, S., Wachsman, A. M., Wang, L., Azab, L., Asadpour, V., Chen, W., Xie, Y., Wu, B., Pandol, S. J., et al. (2022) · Cancer Biomarkers · doi:10.3233/cbm-210273 · Cited by 79 · see citing works
Assessment of Malignant Potential in Intraductal Papillary Mucinous Neoplasms of the Pancreas: Comparison between Multidetector CT and MR Imaging with MR Cholangiopancreatography.
Kang, H.-J., Lee, J. M., Joo, I., Hur, B., Jeon, J., Jang, J.-Y., Lee, K., Ryu, J., Han, J., & Choi, B. (2016) · Radiology · doi:10.1148/radiol.2015150217 · Cited by 69 · see citing works
Surgical overtreatment of pancreatic intraductal papillary mucinous neoplasms: Do the 2017 International Consensus Guidelines improve clinical decision making?
Sharib, J. M., Fonseca, A. L., Swords, D. S., Jaradeh, K., Bracci, P. M., Firpo, M. A., Hatcher, S., Scaife, C. L., Wang, H., Kim, G. E., et al. (2018) · Surgery · doi:10.1016/j.surg.2018.07.014 · Cited by 55 · see citing works
A review of deep learning and radiomics approaches for pancreatic cancer diagnosis from medical imaging
Yao, L., Zhang, Z., Keles, E., Yazici, C., Tirkes, T., & Bagci, U. (2023) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000966 · Cited by 53 · see citing works
“DL can be used for tumor segmentation, crucial for diagnosis and prognostic purposes because the size, shape, and location of the tumor are critical in such tasks.”
Method
Robotic Enucleation for Benign or Borderline Tumours of the Pancreas: A Retrospective Analysis and Comparison from a High-Volume Centre in Asia
Jin, J., Qin, K., Li, H., Wu, Z.-C., Zhan, Q., Deng, X.-X., Chen, H., Shen, B.-Y., Peng, C.-H., & Li, H.-W. (2016) · World Journal of Surgery · doi:10.1007/s00268-016-3655-2 · Cited by 49 · see citing works
Pancreatic intraductal papillary mucinous neoplasms: Current diagnosis and management
Jabłońska, B., Szmigiel, P., & Mrowiec, S. (2021) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v13.i12.1880 · Cited by 57 · see citing works
“Absolute indications: Jaundice; Enhancing mural nodule ≥ 5 mm; MPD ≥ 10 mm; HGD or cancer on cytology; Solid mass European (2018) Relative indications: Cyst size ≥ 4 cm; Enhancing mural nodule ≥ 5 mm/years; Acute pancreatitis (due to IPMN); New onset of diabetes; Rapidly increasing cyst size; Elevated serum levels of…”
Background
Pancreatic Cancer Diagnosis and Management: Has the Time Come to Prick the Bubble?
Moutinho-Ribeiro, P., Macedo, G., & Melo, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00779 · Cited by 41 · see citing works
“They represent up to 10% of the neoplasms of the pancreas, and the ones harboring high-grade dysplasia carry an important risk of malignant transformation (11, 12).”
Background
Artificial Intelligence in the Diagnosis and Treatment of Pancreatic Cystic Lesions and Adenocarcinoma
Jiang, J., Chao, W.-L., Culp, S., & Krishna, S. G. (2023) · Cancers · doi:10.3390/cancers15092410 · Cited by 38 · see citing works
“While the rates of malignancy in IPMNs is well characterized (ranging from 57 to 92% for MD-IPMN and 6 to 46% for BD-IPMNs), few reliable tools exist for predicting the risk of an individual lesion progressing to carcinoma [49].”
Background
Natural History and Treatment Trends in Pancreatic Cancer Subtypes
Pokrzywa, C., Abbott, D., Matkowskyj, K., Ronnekleiv-Kelly, S., Winslow, E., Weber, S., & Fisher, A. V. (2019) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-019-04113-3 · Cited by 38 · see citing works
Deep Learning Applications in Pancreatic Cancer
Patel, H., Zanos, T. P., & Hewitt, D. B. (2024) · Cancers · doi:10.3390/cancers16020436 · Cited by 34 · see citing works
“While the integration of AI in healthcare generates tremendous excitement, it also poses ethical issues that must be addressed before wider adoption.”
Background
Are the Current Guidelines for the Surgical Management of Intraductal Papillary Mucinous Neoplasms of the Pancreas Adequate? A Multi-Institutional Study.
Wilson, G., Maithel, S., Bentrem, D., Abbott, D., Weber, S., Cho, C., Martin, R. C. G., Scoggins, C., Kim, H.-J., Merchant, N., et al. (2017) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2016.12.031 · Cited by 35 · see citing works
The diagnostic role of CT, MRI/MRCP, PET/CT, EUS and DWI in the differentiation of benign and malignant IPMN: A meta-analysis.
Liu, H., Cui, Y., Shao, J., Shao, Z.-J., Su, F., & Li, Y.-Y. (2020) · Clinical imaging · doi:10.1016/j.clinimag.2020.11.018 · Cited by 34 · see citing works
Co-occurrence of IPMN and malignant IPNB complicated by a pancreatobiliary fistula: A case report and review of the literature
Ren, X., Zhu, C.-L., Qin, X., Jiang, H., Xia, T., & Qu, Y.-P. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i1.102 · Cited by 30
Validation of a nomogram to predict the risk of cancer in patients with intraductal papillary mucinous neoplasm and main duct dilatation of 10 mm or less
Jung, W., Park, T., Kim, Y., Park, H., Han, Y., He, J. P., Wolfgang, C. L., Blair, A. B., Rashid, M., Kluger, M. D., et al. (2019) · British journal of surgery · doi:10.1002/bjs.11293 · Cited by 35 · see citing works
Cystic pancreatic lesions: MR imaging findings and management
Morana, G., Ciet, P., & Venturini, S. (2021) · Insights into Imaging · doi:10.1186/s13244-021-01060-z · Cited by 33 · see citing works
“The main differential diagnosis of unifocal BD-IPMN is pseudocysts, MCN and SCN, since sometimes communication with MPD cannot be correctly assessed [66, 68], while the main differential diagnosis of multifocal BDIPMN is with the rare ACCN (Fig.”
BackgroundInfluential
Utility of the 2006 Sendai and 2012 Fukuoka guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas
Hsiao, C.-Y., Yang, C.-Y., Wu, J.-M., Kuo, T.-C., & Yu-Wen, T. (2016) · Medicine · doi:10.1097/md.0000000000004922 · Cited by 26 · see citing works
DWI of Pancreatic Ductal Adenocarcinoma: A Pilot Study to Estimate the Correlation With Metastatic Disease Potential and Overall Survival.
Garces-Descovich, A., Morrison, T. C., Beker, K., Jaramillo-Cardoso, A., Moser, A., & Mortelé, K. (2019) · AJR. American journal of roentgenology · doi:10.2214/ajr.18.20017 · Cited by 23
Pancreatic cancer screening: Still a delusion?
Moutinho-Ribeiro, P., Coelho, R., Giovannini, M. F., & Macedo, G. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.001 · Cited by 21 · see citing works
Role of stromal activin A in human pancreatic cancer and metastasis in mice
Mancinelli, G. E., Torres, C., Krett, N. L., Bauer, J. I., Castellanos, K., McKinney, R., Dawson, D. W., Guzman, G., Hwang, R. F., Grimaldo, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-87213-y · Cited by 25 · see citing works
Pitfalls in the MDCT of pancreatic cancer: strategies for minimizing errors
Haj‐Mirzaian, A., Kawamoto, S., Zaheer, A., Hruban, R. H., Fishman, E. K., & Chu, L. C. H. (2020) · Abdominal Radiology · doi:10.1007/s00261-019-02390-9 · Cited by 23 · see citing works
Accuracy of an administrative database for pancreatic cancer by international classification of disease 10th codes: A retrospective large-cohort study
Hwang, Y., Park, S. M., Ahn, S., Lee, J.-C., Park, Y.-S., & Kim, N. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i37.5619 · Cited by 25 · see citing works
STAT3 signaling in pancreatic ductal adenocarcinoma: a candidate therapeutic target
Al‐Hetty, H. R. A. K., Abdulameer, S. J., Alkubaisy, S. A., Zaid, S. A., Jalil, A. T., & Jasim, I. K. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154425 · Cited by 16 · see citing works
Clinical Applications of Classical and Novel Biological Markers of Pancreatic Cancer
Pekarek, L., Fraile‐Μartinez, O., Montero, C. G., Sáez, M. A., Barquero-Pozanco, I., del Hierro-Marlasca, L., Castro-Martinez, P. D., Romero-Bazán, A., Álvarez-Mon, M. Á., Monserrat, J., et al. (2022) · Cancers · doi:10.3390/cancers14081866 · Cited by 18 · see citing works
SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN
Zhang, C.-L., Shen, Q., Liu, F., Yang, F., Gao, M.-Q., Jiang, X.-C., Li, Y., Zhang, X.-Y., En, G., Pan, X., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-44646-x · Cited by 15 · see citing works
“There are three main types of IPMN: the main pancreatic duct type (MD-IPMN), branch-duct type (BD-IPMN), and mixed type 11 .”
Background
Misdiagnosis of pancreatic intraductal papillary mucinous neoplasms and the challenge of mimicking lesions: imaging diagnosis and differentiation strategies
Yasrab, M., Kwak, S. J., Khoshpouri, P., Fishman, E. K., & Zaheer, A. (2024) · Abdominal Radiology · doi:10.1007/s00261-024-04551-x · Cited by 11 · see citing works
“IPMNs have a slight male predilection and are typically diagnosed incidentally at a mean age of 60 [8].”
Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts
Li, F., Malli, A., Cruz-Monserrate, Z., Conwell, D., & Krishna, S. (2018) · World Journal of Gastrointestinal Endoscopy · doi:10.4253/wjge.v10.i1.1 · Cited by 11 · see citing works
Improving Pancreatic Cyst Management: Artificial Intelligence-Powered Prediction of Advanced Neoplasms through Endoscopic Ultrasound-Guided Confocal Endomicroscopy
Jiang, J. H., Chao, W., Cao, T., Culp, S., Napoléon, B., El-Dika, S. S., Machicado, J. D., Pannala, R., Mok, S. R. S., Luthra, A., et al. (2023) · Biomimetics · doi:10.3390/biomimetics8060496 · Cited by 9 · see citing works
“BD-IPMNs are the most common PCLs, with the reported risk of malignancy ranging between 6 and 46% [5–7].”
Background
Bioinformatic Analysis and Integration of Transcriptome and Proteome Results Identify Key Coding and Noncoding Genes Predicting Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Saha, B., Chhatriya, B., Pramanick, S., & Goswami, S. (2021) · BioMed Research International · doi:10.1155/2021/1056622 · Cited by 8 · see citing works
“However, the incidence of malignancy, as reported, varies from 57% to 92% in case of MD-IPMN and from 6% to 46% in BD-IPMN [2].”
Abbreviated Magnetic Resonance Imaging With Breath‐Hold Three‐Dimensional Magnetic Resonance Cholangiopancreatography: Assessment of Malignant Risk of Pancreatic Intraductal Papillary Mucinous Neoplasm
Yoo, J., Min, J. H., Lee, D. H., Hur, B. Y., Kim, S. W., & Kim, E. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27612 · Cited by 9 · see citing works
“While observation may be sufficient for low-risk IPMNs, invasive IPMNs showed worse prognosis with a 5-year survival rate of 27–60%, with surgical resection to improve patient survival.(3,4) Therefore, regular surveillance is important to determine the appropriate surgical indications.”
Background
Effectiveness of steroid therapy for pancreatic cysts complicating autoimmune pancreatitis and management strategy for cyst-related complications
Kuraishi, Y., Watanabe, T., Muraki, T., Ashihara, N., Ozawa, M., Nakamura, A., Kanai, K., Hamano, H., & Kawa, S. (2019) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2019.1623307 · Cited by 8
“We diagnosed IPMN based on distinctive image findings on CT, MRI, and EUS, including dilated ductal system morphology and complex cystic mass, the presence of mucin or mural nodules, and communication of the cystic mass to the pancreatic duct [20].”
Method
Are the screening guidelines for branch duct intraductal papillary mucinous neoplasms cost‐effective in an Australian setting?
Lai, T., Bull, N. B., Goonawardena, J., Bradshaw, L., Fox, A. M., & Hassen, S. (2023) · ANZ Journal of Surgery · doi:10.1111/ans.18697 · Cited by 9 · see citing works
MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY (MRCP) VERSUS ENDOSONOGRAPHY-GUIDED FINE NEEDLE ASPIRATION (EUS-FNA) FOR DIAGNOSIS AND FOLLOW-UP OF PANCREATIC INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS
Costa, D. A. P. D. D., Guerra, J., Goldman, S., Kemp, R., Santos, J. S., Ardengh, J., Ribas, C., Nassif, P. A., & Ribas-Filho, J. (2019) · Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · doi:10.1590/0102-672020190001e1471 · Cited by 7
Intraductal papillary mucinous neoplasm complicated by a gastropancreatic fistula
Patel, A. B., Allen, A., Kuwahara, J., Wadsworth, T., Loeffler, D. M., & Xie, K. (2018) · Radiology Case Reports · doi:10.1016/j.radcr.2018.11.015 · Cited by 7
Cystic pancreatic neoplasms: what we need to know and new perspectives
Galluzzo, A., Bogani, S., Fedeli, F., Danti, G., & Miele, V. (2024) · Journal of Medical Imaging and Interventional Radiology · doi:10.1007/s44326-024-00022-1 · Cited by 4 · see citing works
“[18].”
Pancreatic colloid adenocarcinoma arising from intraductal papillary mucinous neoplasm: Radiologic-pathologic correlation with cinematic rendering
Markovitz, M., Jiang, K., Kim, D., Rose, T., Permuth, J., & Jeong, D. (2023) · Acta Radiologica Open · doi:10.1177/20584601231157046 · Cited by 6
“Intraductal papillary mucinous neoplasms (IPMN) are well described pancreatic lesions accounting for 3–5% of all pancreatic tumors.(1) IPMNs are classified into four histopathological types: gastric, intestinal, pancreatobiliary, and oncocytic.”
Background
The Use of Intraoperative Frozen Sections in Guiding the Extent of Pancreatic Resections for Intraductal Papillary Mucinous Neoplasms
Chi, Z., Dhall, D., & Mertens, R. (2022) · Pancreas · doi:10.1097/mpa.0000000000001963 · Cited by 7 · see citing works
Exosomal glypican-1 for risk stratification of pancreatic cystic lesions: A case of pathological progression in the absence of any suspicious imaging finding.
Moutinho-Ribeiro, P., Costa-Moreira, P., Adem, B., Batista, I., Almeida, M., Barroca, H., Lopes, J., Carneiro, F., Melo, S., & Macedo, G. (2020) · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · doi:10.1016/j.pan.2020.01.015 · Cited by 6 · see citing works
Conditional survival analysis for patients with intraductal papillary mucinous neoplasms (IPMNs) undergoing curative resection.
Gaitanidis, A., Alevizakos, M., Tsaroucha, A., Tsalikidis, C., Simopoulos, C., & Pitiakoudis, M. (2018) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2018.01.011 · Cited by 6
Navigating Intraductal Papillary Mucinous Neoplasm Management through Fukuoka Consensus vs. European Evidence-Based Guidelines on Pancreatic Cystic Neoplasms—A Study on Two European Centers
Djordjevic, V. R., Knežević, D., Trotovšek, B., Tomažič, A., Petrič, M., Hadžialjević, B., Grubor, N., & Djokić, M. (2024) · Cancers · doi:10.3390/cancers16112156 · Cited by 5 · see citing works
“These growths have a potential risk of developing into malignancies [5].”
Background
Intraductal Papillary Mucinous Neoplasm Arising from Heterotopic Pancreas in Stomach: A Case Report and Review of Literature
Pang, Y., Liu, Y., Liu, Q., & Hou, G. (2022) · International Journal of Surgical Pathology · doi:10.1177/10668969221117990 · Cited by 7 · see citing works
“It is primarily characterized by cystic dilation of pancreatic ducts with variable mucin secretion, papillary epithelium, and dysplasia.(4) In clinical practice, the differential diagnosis of IPMN and other malignancies, especially ductal adenocarcinoma is still very difficult, as it usually complicated with invasive…”
Background
Mucin-filled CBD, difficult to manage cholangitis
Kumar, M., Sonika, U., Sachdeva, S., & Dalal, A. (2021) · BMJ Case Reports · doi:10.1136/bcr-2020-238363 · Cited by 5
A CASE OF CYSTIC PHEOCHROMOCYTOMA WITH HYPERTENSION AND HEADACHES MIMICKING A LARGE PANCREATIC CYSTIC TUMOR
Yamagata, S., Kageyama, K., Nomura, A., Murasawa, S., Ogasawara, M., Kawaguchi, T., Tazawa, Y., & Ogawa, Y. (2017) · AACE Clinical Case Reports · doi:10.4158/ep161408.cr · Cited by 4 · see citing works
Conditions at risk of pancreatic cancer: The radiology perspective
Cannella, R., Burgio, M. D., Maino, C., Matteini, F., Ippolito, D., Boraschi, P., Zamboni, G. A., & Vernuccio, F. (2025) · European Journal of Radiology · doi:10.1016/j.ejrad.2025.112119 · Cited by 2 · see citing works
Successful embolization with subsequent pancreaticoduodenectomy for intraductal papillary mucinous neoplasm hemorrhage: a case report and review of literature
Tanemura, M., Cho, A., Niwa, Y., Ishita, T., Mouri, T., Sugishita, T., Higuchi, R., Ota, M., Yoshida, K., & Katagiri, S. (2024) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-024-02035-5 · Cited by 3
“Complicated lesions associated with IPMNs, such as acute pancreatitis, perforation, and fistula formation, have been documented [1–4].”
Current and Emerging Applications of Artificial Intelligence (AI) in the Management of Pancreatobiliary (PB) disorders
Bush, N., Khashab, M., & Akshintala, V. (2024) · Current Gastroenterology Reports · doi:10.1007/s11894-024-00942-8 · Cited by 3 · see citing works
“Intra-ductal papillary neoplasms (IPMNs) represent up to 50% of incidentally detected pancreatic cystic lesions and carry an inherent risk for progression to PDAC [22].”
Fistula formation into other organs secondary to intraductal papillary mucinous neoplasm of the pancreas: A case report and literature review
Shishido, Y., Mitsuoka, E., Ito, R., Ishii, M., & Fujimoto, K. (2023) · Medicine · doi:10.1097/md.0000000000034288 · Cited by 3
“IPMN accounts for less than 10% of all pancreatic neoplasms and exhibits a unique range of clinical features compared to invasive ductal adenocarcinoma.[1] IPMNs display a broad spectrum of dysplasia, ranging from low and high-grade dysplasia (carcinoma in situ) to invasive carcinoma.”
Background
Main-Duct Intraductal Papillary Mucinous Neoplasm Complicated by a Pancreaticogastric Fistula and a Pancreaticocholedocal Fistula
Patel, S., Salmi, U. A., & Shamousi, K. A. (2023) · Cureus · doi:10.7759/cureus.38502 · Cited by 3
“Worrisome features of carcinoma include duct size 5-9 mm and cyst size ≥30 mm [3].”
Background
Pancreatic cancer in patient with groove pancreatitis: Potential pitfalls in diagnosis
Lugo-Fagundo, E., Weisberg, E. M., & Fishman, E. K. (2022) · Radiology Case Reports · doi:10.1016/j.radcr.2022.09.020 · Cited by 3 · see citing works
Intraductal papillary mucinous neoplasm complicated with intraductal bleeding in a young woman mimicked a cystic solid pseudo-papillary tumor: a case report
Wu, J.-M., Lin, Y., & Wu, J.-W. (2020) · BMC Gastroenterology · doi:10.1186/s12876-020-01436-3 · Cited by 3
“AP is the most common complications of IPMN, approximately 20% of IPMN complicated with acute pancreatitis of mild to moderate severity [4].”
BackgroundResult
Helicobacter pylori is undetectable in intraductal papillary mucinous neoplasm.
Baysal, B., Ince, A., Gültepe, B., Güçin, Z., Malya, F. U., Tozlu, M., Senturk, H., Bagci, P., Çelikel, Ç., Aker, F., et al. (2016) · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · doi:10.1016/j.pan.2016.06.005 · Cited by 3
“Intraductal papillary mucinous neoplasm, a cystic neoplasm with characteristic mucinous secretion [18,19], is believed to be a”
Background
Preoperative Prediction of Subtype and Artificial Intelligence–Driven Endomicroscopy Detection of Advanced Neoplasia in Intraductal Papillary Mucinous Neoplasms
Koehler, B., Chen, W., Esnakula, A. K., Frankel, W. L., Abdelbaki, A., Culp, S., Li, Z., Chao, W., Hart, P. A., Pawlik, T. M., et al. (2025) · Techniques and Innovations in Gastrointestinal Endoscopy · doi:10.1016/j.tige.2025.250956 · Cited by 2 · see citing works
Intracholecystic papillary-tubular neoplasm of the gallbladder
Wong, L. H., Ferrer, G., & Mayo, S. (2021) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-021-05193-w · Cited by 2
Main duct intraductal papillary mucinous neoplasm of the pancreas with spontaneous fistula into stomach
Kandelaki, H., Page, B., & Raimes, S. (2020) · ANZ journal of surgery · doi:10.1111/ans.16139 · Cited by 2
“Obstruction of pancreatic ducts by secretion of thick mucin leads to increased ductal pressure, a precursor to mechanical fistula formation, and progressive parenchymal atrophy resulting in pancreatic insufficiency.(5) Fistula formation enables release of enzymes; however, in our case, this occurred in an acidic stoma…”
Background
Intraductal papillary mucinous neoplasm of pancreas
Panteleev, V. I., Gorin, D. S., Kaldarov, A. R., & Kriger, A. G. (2019) · Pirogov Russian Journal of Surgery · doi:10.17116/hirurgia201911181 · Cited by 3 · see citing works
Imaging assessment and radiological features of pancreatic cystic lesions
Brandi, N., Giampalma, E., Inchingolo, R., Catalano, O. A., Midulla, M., & Renzulli, M. (2025) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2025.102053 · Cited by 1 · see citing works
Technical success, clinical efficacy, and safety of endoscopic minor papilla interventions for symptomatic pancreatic diseases
Ren, X., Qu, Y.-P., Xia, T., & Tang, X.-F. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i20.100192 · Cited by 1
“…third case, multiple tumors were presented inside the pancreatic duct, and appeared to be malignant with atypical vascular images[33] as shown by ultra-thin pancreatoscopy, with the dorsal pancreatic duct dilation of more than 12 mm as shown by pancreatography, indicative of surgical therapy[19].”
A Comparison of Single Dimension and Volume Measurements in the Risk Stratification of Pancreatic Cystic Lesions
Ryoo, D. Y., Koehler, B., Rath, J., Shah, Z. K., Chen, W., Esnakula, A., Hart, P. A., & Krishna, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185871 · Cited by 1
“They also have a signiﬁcant malignant potential, with a mean malignancy rate of 61% in main-duct IPMNs (MD-IPMNs) when the duct diameter is ≥ 10 mm and a malignancy rate of 25.5% in branch-duct IPMNs (BD-IPMNs) when the cyst diameter is ≥ 4 cm [7].”
BackgroundInfluential
GASTROPANCREATIC FISTULA SECONDARY TO A PANCREATIC INTRADUCTAL PAPILLARY MUCINOUS NEOPLASIA - ENDOSCOPIC ULTRASOUND AND UPPER GASTROINTESTINAL ENDOSCOPY FINDINGS.
Bonin, E., de Souza, R. C. A., Mueller, R. P., Ioshii, S., & Ardengh, J. (2021) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202100000-44 · Cited by 1
A mixed-type intraductal papillary mucinous neoplasm of the pancreas with a histologic combination of gastric and pancreatobiliary subtypes in a 70-year-old woman: a case report
Ismail, S., Darwisho, R., Ali, M., Haidar, M., Houreih, M. A., & Alshehabi, Z. (2020) · Journal of Medical Case Reports · doi:10.1186/s13256-020-02464-z · Cited by 1
Premalignant lesions and cellular senescence
Georgakopoulou, E. A., Evangelou, K., & Gorgoulis, V. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00001-8 · Cited by 3 · see citing works
Management of Intraductal Papillary Mucinous Neoplasms
Sham, J., & Weiss, M. (2019) · Clinical Algorithms in General Surgery · doi:10.1007/978-3-319-98497-1_99 · Cited by 1
Primary Pancreatic Cystic Neoplasms
Schneider, A. B., & Roggin, K. (2019) · Shackelford's Surgery of the Alimentary Tract, 2 Volume Set · doi:10.1016/b978-0-323-40232-3.00098-4 · Cited by 1 · see citing works
Prognostic Value of Digitally Quantified CDX2 Expression in Pancreatic Ductal Adenocarcinoma Without Intestinal Differentiation
Endo, M., Niisato, Y., Shimomura, O., Sakamoto, N., Sugita, S., Hagiwara, Y., Fukuda, S., Matsubara, D., Oda, T., & Tsuchiya, K. (2026) · International Journal of Surgical Pathology · doi:10.1177/10668969261437128
When to operate pancreatic intraductal papillary mucinous neoplasm: Literature review
Alghamdi, T. H. (2026) · World Journal of Clinical Oncology · doi:10.5306/wjco.v17.i3.114990
Pancreaticobiliary Fistula Caused by Intraductal Papillary Mucinous Adenoma Requiring Pancreaticoduodenectomy
Nagao, M., Suto, H., Matsukawa, H., Fujiwara, J., Kagawa, S., Fuke, T., Shimizu, Y., Nishigaki, A., Ando, Y., Oshima, M., et al. (2026) · Surgery Case Reports · doi:10.70352/scrj.cr.25-0779
Hybrid Deep Learning and Gradient Boosting Framework for Early Detection of Pancreatic Cancer
Raja, P., Pradeepa, P., & Priyadarsini, S. (2026) · 2026 4th International Conference on Intelligent Data Communication Technologies and Internet of Things (IDCIoT) · doi:10.1109/idciot67589.2026.11455890
“Annotation-efficient models [14] reported accuracy around 89%, whereas our approach with augmentation achieved >94%, further confirming robustness.”
Influential
Difficulties of CT and MRI Diagnostics of Intraductal Papillary Mucinous Neoplasm of the Pancreas Associated with Invasive Carcinoma
Arablinskii, A. V., Lukianchenko, A. B., & Lobanova, N. (2025) · Journal of oncology: diagnostic radiology and radiotherapy · doi:10.37174/2587-7593-2025-8-1-70-75
Complicated intraductal papillary mucinous neoplasia requiring a two-stage operation
Marinov, V., Karagyozov, P., Kostov, K., Emilova, N., Ivanova, S., Chaneva, M., Atanasova, V., Atanasov, P., & Becheva, M. V. V. (2024) · Pharmacia · doi:10.3897/pharmacia.71.e133902
“These complications are rare and may be caused by high ductal pressure, autodigestion of pancreas parenchyma, or direct spread of invasive neoplasm (Machado et al. 2015).”
Background
Endoscopic Evaluation and Therapy of Intraductal Papillary Mucinous Neoplasms
Bush, N., Krishna, S., Abdelbaki, A., Carpenter, E. S., & Machicado, J. (2024) · Digestive Disease Interventions · doi:10.1055/s-0045-1807743
Editorial for “Hyperpolarized 13C Metabolic MRI of Patients with Pancreatic Ductal Adenocarcinoma”
Robb, F. J. L., & Chen, A. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29163
“3 This recent article on HP [1 – 13C] MRI and its application to pancreatic ductal cancer has created excitement as a fascinating new technique for the disease understanding and evaluation and as a newly evolving tool of precision molecular imaging.”
Influential
A Rare Case of a Pancreatic Intraductal Oncocytic Papillary Neoplasm Associated With Invasive Adenocarcinoma Presenting as a Gastric Mass
Younes, A. I., Hu, X., Peng, L., & Chi, Z.-K. (2023) · Cureus · doi:10.7759/cureus.47886
Evaluation of intraductal papillary mucinous neoplasms detected incidentally with magnetic resonance cholangiopancreatography
Nalbant, M. (2023) · The European Research Journal · doi:10.18621/eurj.1282203
“Malignancy rates are considerably greater for MD-IPMN and mixed types and lower for BD-IPMN [23].”
BackgroundMethodInfluential
Intraductal papillary mucinous neoplasm mimicking a duodenal tumor
Jeong, M. (2023) · Radiology Case Reports · doi:10.1016/j.radcr.2022.12.043
“IPMNs account for less than 10% of all pancreatic neoplasms [2] , and their incidence has increased with the development of diagnostic techniques.”
BackgroundInfluential
Spontaneous Infection of a Nonmalignant Intraductal Papillary Mucinous Neoplasm
Ashhab, A. A., Podboy, A., & Lo, S. (2022) · ACG Case Reports Journal · doi:10.14309/crj.0000000000000736
Visible Intraductal Papillary Mucinous Neoplasm after Drinking Water
Kim, D.-J., Lee, S., Joo, Y.-B., Park, Y., Jun, T., Ahn, J., Lee, I., & Choi, Y. (2020) · Clinical Ultrasound · doi:10.18525/cu.2020.5.1.30
Disease-free long survival after stump recurrence and reoperation of pancreatic IPMN with invasive carcinoma
Santoro, E., Visca, P., Santoro, R., Mancini, P., & Santoro, E. (2019) · Chirurgia · doi:10.23736/s0394-9508.18.04824-6
“For a full and correct diagnosis above and beyond MRI and CT scans you can and should practice an endo ultrasonography with fine-needle aspiration for cytologic examination and assay of markers, as well as the endoscopic removal of pancreatic juice for cytologic examination and dosages of carcino-embryonic antigen [12…”
Method
An appraisal of pancreatic cyst fluid molecular markers
Modi, R. M., Pavurala, R., & Krishna, S. (2017) · International Journal of Gastrointestinal Intervention · doi:10.18528/gii170005
Case Report of Pancreas Divisum and Main Duct Intraductal Papillary Mucinous Neoplasm of the Pancreas
Santos, P. (2016) · doi:10.24966/csmc-8801/100033
Caratéristiques épidémiologiques et morphologiques des principaux kystes pancréatiques
Maniére, T. (2016) · Acta Endoscopica · doi:10.1007/s10190-016-0550-5
Central Pancreatectomy: A Center of Debate of Risk versus Benefit
Machado, N. (2015) · doi:10.4172/2165-7092.1000e138
Self-citation
Pathogenesis, Epidemiology, and Prognosis of Pancreatic Adenocarcinomas
Kim, K. K., Gaddam, S., & Liu, Q. Y. (2021) · Hepato-Pancreato-Biliary Malignancies · doi:10.1007/978-3-030-37482-2_28-1
An Overview of the Tumor Microenvironment and Response to Immunotherapy in Gastrointestinal Malignancies
Herting, C. J., & Lesinski, G. B. (2021) · Cancer immunotherapy · doi:10.1007/13905_2021_1
[Diagnostic and treatment of the intraductal papillary mucinous tumor of pancreas].
Krieger, A., Karmazanovskiy, G., Panteleev, V., Gorin, D. S., Vetsheva, N., Berelavichus, S., Kaldarov, A., & Glotov, A. (2020) · Khirurgiia · doi:10.17116/hirurgia202001114
“Sometimes intraductal papillary mucinous tumor can be presented as a solid formation due to massive proliferation of tumor tissue [12].”
Background
Cystic Lesions of the Pancreas
Başar, O., & Brugge, W. (2019) · ERCP · doi:10.1016/b978-0-323-48109-0.00051-1
Imaging of Pancreatic Malignancies
Czeyda-Pommersheim, F., Kalb, B., & Martín, D. R. (2018) · doi:10.1007/978-3-319-58256-6_7
Mucinous Tumours of the Pancreas
Rao, R., Healey, P., & Halloran, C. (2018) · Springer eBooks · doi:10.1007/978-981-10-8755-4_12

Authors: Machado, N., al Qadhi, H., & al Wahibi, K.
Venue: North American Journal of Medical Sciences
Publisher: Medknow
Published: 2015
Volume: 7
Issue: 5
Pages: 160
ISSN: 1947-2714 (ISSN-L)
DOI: 10.4103/1947-2714.157477
PMC: PMC4462811
OpenAlex: W1660506500
Cited by: 149
References: 100
Citations by year: 2026: 4 · 2025: 10 · 2024: 11 · 2023: 22 · 2022: 16 · 2021: 19 · 2020: 12 · 2019: 16 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 3
FWCI: 1.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: North American Journal of Medical Sciences (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
Keywords: intraductal papillary mucinous neoplasm, pancreatic ductal adenocarcinoma, main duct IPMN, branch duct IPMN, malignant transformation, risk stratification, pancreatic cysts, magnetic resonance imaging, endoscopic ultrasound, pancreatoscopy, surgical resection, postoperative follow-up

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Intraductal papillary mucinous neoplasm of pancreas

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