Nitric oxide deficiency in pulmonary hypertension: pathobiology and implications for therapy
Open accessAbstract
Nitric oxide (NO) is a diffusible gas with diverse roles in human physiology and disease. Significant progress in the understanding of its biological effects has taken place in recent years. This has led to a better understanding of the pathobiology of pulmonary hypertension (PH) and the development of new therapies. This article provides an overview of the NO physiology and its role in the pathobiology of lung diseases, particularly PH. We also discuss current and emerging specific treatments that target NO signaling pathways in PH.
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The hallmark feature of PAH and other forms of PH is reduced bioavailability of NO signaling and poor endothelial responsiveness to triggers of vasodilatation.
“The hallmark feature of PAH and other forms of PH is reduced bioavailability of NO signaling and poor endothelial responsiveness to triggers of vasodilatation[28–34].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [34]
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References 179 · Cited by 86
- Authors
- Tonelli, A. R., Haserodt, S., Aytekin, M., & Dweik, R. A.
- Affiliations
- Department of Pulmonary Allergy and Critical Care Medicine Respiratory Institute Cleveland Ohio USA
- Cleveland Clinic (US)
- Corresponding author
- Dweik, Raed A.
- Venue
- Pulmonary Circulation
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 3
- Issue
- 1
- Pages
- 20-30
- ISSN
- 2045-8932 (ISSN-L)
- 2045-8940
- PMC
- PMC3641730
- OpenAlex
- W2118726397
- Cited by
- 86
- References
- 179
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 13 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 3
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Pulmonary Circulation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources
- National Institutes of Health (HL081064, HL107147, HL095181, RR026231)
- Ohio Department of Development
- American Heart Association (0826095H)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Genetics › Vascular Anomalies and Treatments
- Keywords
- nitric oxide, pulmonary hypertension, nitric oxide signaling, pathobiology, lung disease, vasodilation
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