Probiotic based therapy for atopic dermatitis: Outcomes of clinical studies
Open accessAbstract
Atopic dermatitis (AD) is one of the chronic inflammatory skin diseases characterized by conflicts in epidermal barrier and wired immune response. About 10%-20% of the population is affected by AD, especially infants. Topical application of corticosteroids, antihistamines, and antibiotics are used to treat severe AD condition. Recent studies suggest that disturbance in skin and intestinal microbiota is majorly linked to skin diseases. Probiotics are known for the positive alteration of an individual's microbiome and associated with several health benefits. Clinical studies suggest that probiotic and synbiotic supplementation protect infants from a stringent AD to some extent. Reduction in the risk of AD development upon probiotic supplementation was not observed in all studied populations. Further studies are needed to regularize microbiome of skin and intestine in AD patients that may reduce AD severity. Present review summarizes the outcomes from clinical studies on AD using probiotic as an alternative treatment candidate.
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Probiotic efficacy appears to be strain- and population-specific, with some strains effective in certain patient groups but not in others.
“Accordingly, probiotic efficacy appears to be strain- and population-specific, with some strains being effective in certain patient groups but not in others [92,93], and there is evidence that probiotics may increase the risk of sensitization in individuals predisposed to allergic diseases [94].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [92]
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References 60 · Cited by 22
- Authors
- Sivamaruthi, B., Kesika, P., & Chaiyasut, C.
- Affiliations
- Chiang Mai University (TH)
- Venue
- Asian Pacific Journal of Tropical Biomedicine
- Published
- 2018
- Volume
- 8
- Issue
- 6
- Pages
- 328
- ISSN
- 2221-1691 (ISSN-L)
- OpenAlex
- W2811504106
- Cited by
- 22
- References
- 60
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 1
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Asian Pacific Journal of Tropical Biomedicine (publishedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic dermatitis, probiotics, synbiotics, skin microbiome, gut microbiota, infants, skin barrier, complementary and alternative medicine, clinical outcomes
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