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Hair dye dermatitis and p-phenylenediamine contact sensitivity: A preliminary report
Open accessAbstract
Background: The contact allergic reactions from p -phenylenediamine (PPD) in hair dyes vary from mild contact dermatitis to severe life- threatening events (angioedema, bronchospasm, asthma, renal impairment). Objectives: To study the clinical patterns and PPD contact sensitivity in patients with hair-dye dermatitis. Materials and Methods: Eighty (M:F 47:33) consecutive patients aged between 18 and 74 years suspected to have contact allergy from hair dye were studied by patch testing with Indian Standard Series including p -phenylenediamine (PPD, 1.0% pet). Results: 54 Fifty-four (M:F 21:33) patients showed positive patch tests from PPD. Eight of these patients also showed positive patch test reaction from fragrance mix, thiuram mix, paraben mix, or colophony. Fifty-seven (71%) patients affected were aged older than 40 years. The duration of dermatitis varied from < 1 month to > 1 year with exacerbation following hair coloring. Forty-nine patients had dermatitis of scalp and/or scalp margins and 23 patients had face and neck dermatitis. Periorbital dermatitis, chronic actinic dermatitis, and erythema multiforme-like lesions were seen in 4, 2, and 1 patients, respectively. Conclusions: Hair dyes and PPD constitute a significant cause of contact dermatitis. There is an urgent need for creating consumer awareness regarding hair-dyes contact sensitivity and the significance of performing sensitivity testing prior to actual use.
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“Fragrance ingredients such as fragrance-mix, balsam of Peru and colophony, as well as emulsifying ingredients such as lanolin, amerchol L-101 and propylene glycol, are also common allergens in cosmetics that cause contact dermatitis.”
From Allergens Causing Allergic Contact Dermatitis in Cosmetic Products: A Systematic Review (2024) · cites this paper as [16]
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“The following most common allergen in this study was fragrance-mix I.”
From Allergens Causing Allergic Contact Dermatitis in Cosmetic Products: A Systematic Review (2024) · cites this paper as [16]
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Research works printed but not linked: 28
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Cited by
Sorted by citations
Mujtaba, S. F., Masih, A. P., Alqasmi, I., Alsulimani, A., Khan, F. H., & Haque, S. (2021) · Antioxidants · doi:10.3390/antiox10071008 · Cited by 25
Allergens Causing Allergic Contact Dermatitis in Cosmetic Products: A Systematic Review
Oktaviani, T., Widhiati, S., Kariosentono, H., Irawanto, M. E., & Oktavriana, T. (2024) · SKIN The Journal of Cutaneous Medicine · doi:10.25251/skin.8.6.1 · Cited by 3
Metadata
- Authors
- Gupta, M., Mahajan, V. K., Mehta, K. S., & Chauhan, P. S.
- Affiliations
- Dr. Rajendra Prasad Government Medical College (IN)
- Corresponding author
- Mahajan, Vikram K.
- ORCID
- Mehta, Karaninder S.
- Venue
- Indian Dermatology Online Journal
- Published
- 2015-07
- Volume
- 6
- Issue
- 4
- Pages
- 241-246
- ISSN
- 2229-5178 (ISSN-L)
- 2249-5673
- PMC
- PMC4513401
- OpenAlex
- W2148562774
- Cited by
- 33
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Dermatology Online Journal (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- p-phenylenediamine, contact allergy, patch testing, scalp dermatitis, fragrance mix, thiuram mix, rosin, erythema multiforme-like lesions, chronic actinic dermatitis, periorbital dermatitis, consumer awareness
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