Cited by 23Pituitary Gland Disorders and TreatmentsHormonal Regulation and HypertensionAdrenal and Paraganglionic Tumors

Endocrine hypertension - Cushing′s syndrome

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Singh, Yashpal, Kotwal, Narendra, Menon, AS·2011·Indian Journal of Endocrinology and Metabolism

Abstract

Hypertension is a major and frequent comorbid finding of Cushing's syndrome. This review discusses the etiology and pathophysiology of hypertension in Cushing's syndrome, while suggesting methods of management of this condition. It also provides an overview of diagnosis and management strategies in this disease.

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Crossref · 10.4103/2230-8210.86973

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  • Although small cohort studies suggest high BP is highly prevalent (often exceeding 80%) among patients with Cushing syndrome, the overall frequency of hypertension among patients with Cushing syndrome remains to be accurately characterized.

    “Although a variety of relatively small cohort studies suggest that high BP is highly prevalent (often exceeding 80%),324,325 the overall frequency of hypertension, mild or severe, among patients with Cushing syndrome remains to be accurately characterized.”
  • Hypercortisolism can promote hypertension through additional pathways including activating the renin-angiotensin system, sensitizing the vasculature to catecholamines, and impairing endogenous nitric oxide bioavailability.

    “However, it is also recognized the hypercortisolism can promote hypertension through a variety of additional pathways (eg, activating the renin-angiotensin system, sensitizing the vasculature to catecholamines, and impairing endogenous nitric oxide bioavailability).324,325”

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References 17 · Cited by 23

Authors
Singh, Y., Kotwal, N., & Menon, A.
Affiliations
Armed Forces Medical College (IN)
Corresponding author
Singh, Yashpal
Venue
Indian Journal of Endocrinology and Metabolism
Published
2011
Volume
15
Issue
8
Pages
313
ISSN
2230-8210 (ISSN-L)
OpenAlex
W2090676392
Cited by
23
References
17
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2013: 1
FWCI
0.26
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
Keywords
Cushing's syndrome, endocrine hypertension, hypercortisolism, hypertension pathophysiology, hypertension etiology, antihypertensive therapy

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