Endocrine hypertension - Cushing′s syndrome
Open accessAbstract
Hypertension is a major and frequent comorbid finding of Cushing's syndrome. This review discusses the etiology and pathophysiology of hypertension in Cushing's syndrome, while suggesting methods of management of this condition. It also provides an overview of diagnosis and management strategies in this disease.
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Although small cohort studies suggest high BP is highly prevalent (often exceeding 80%) among patients with Cushing syndrome, the overall frequency of hypertension among patients with Cushing syndrome remains to be accurately characterized.
“Although a variety of relatively small cohort studies suggest that high BP is highly prevalent (often exceeding 80%),324,325 the overall frequency of hypertension, mild or severe, among patients with Cushing syndrome remains to be accurately characterized.”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [325]
Hypercortisolism can promote hypertension through additional pathways including activating the renin-angiotensin system, sensitizing the vasculature to catecholamines, and impairing endogenous nitric oxide bioavailability.
“However, it is also recognized the hypercortisolism can promote hypertension through a variety of additional pathways (eg, activating the renin-angiotensin system, sensitizing the vasculature to catecholamines, and impairing endogenous nitric oxide bioavailability).324,325”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [325]
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References 17 · Cited by 23
- Authors
- Singh, Y., Kotwal, N., & Menon, A.
- Affiliations
- Armed Forces Medical College (IN)
- Corresponding author
- Singh, Yashpal
- ORCID
- Kotwal, Narendra
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2011
- Volume
- 15
- Issue
- 8
- Pages
- 313
- ISSN
- 2230-8210 (ISSN-L)
- PMC
- PMC3230089
- OpenAlex
- W2090676392
- Cited by
- 23
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2013: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Endocrinology and Metabolism (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Keywords
- Cushing's syndrome, endocrine hypertension, hypercortisolism, hypertension pathophysiology, hypertension etiology, antihypertensive therapy
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