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Nonfluoride remineralization: An evidence-based review of contemporary technologies
Abstract
Since past few years, there have been many strategies to combat dental caries, erosion, hypersensitivity, and many other oral conditions. The last decade has seen many advanced researches in the field of dentistry. The scope of dentistry has evolved from only a curative one to a largely preventive one. There have been technologies available for the minimal invasive cure of dental caries, early diagnosis and early reversal of the initial carious lesion using nonoperative techniques. There has also more focus being made to treat dental caries as a process rather than curing the lesion only. The role of saliva, demineralization and remineralization has been better understood. The aim of this paper is to review the contemporary nonfluoridated systems available for remineralization therapy and ideas for their implementation into clinical practice. A search of articles from PubMed and Medline and databases like Google and Google scholar, ScienceDirect and Wiley with the keywords remineralization, demineralization, nonfluoridated demineralizing agents was conducted in the month of August 2012 out of a total 114 articles, 86 articles have been used in the present evidence-based review.
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“CPP–ACP and calcium compete for identical binding sites on S. mutans, with CPP–ACP demonstrating double the binding affinity to bacterial cells compared to calcium.”
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“The combined anticariogenic effect of CPP–ACP and fluoride is also associated with the presence of ACP fluoride on the tooth surface, which is facilitated by CPP.11”
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Research works printed but not linked: 68
- Zero, 2006, Dentifrices, mouthwashes, and remineralization/caries arrestment strategies, BMC Oral Health, S9
- Wolff, 2009, The cariogenic dental biofilm: Good, bad or just something to control?, Braz Oral Res, 31
- Stephan, 1940, Changes in hydrogen ion concentration on tooth surfaces and in carious lesions, J Am Dent Assoc, 718
- Meyer-Lueckel, 2002, The effect of commercially available saliva substitutes on predemineralized bovine dentin in vitro, Oral Dis, 192
- Alauddin SS. In vitro remineralization of human enamel with bioactive glass containing dentifrice using confocal microscopy and nanoindentation analysis for early caries defense. A thesis, University of Florida; 2004. Available from: http://www.ufdc.ufl.edu/ufe0007162/00001. [Last accessed on 2014 Aug 27].
- Dowker, 1999, Crystal chemistry and dissolution of calcium phosphate in dental enamel, Mineral Mag, 791
- Liu, 2011, The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial carieslike dentin, Dent Mater, 465
- Bertassoni, 2011, Mechanical recovery of dentin following remineralization in vitro - an indentation study, J Biomech, 176
- Bertassoni, 2010, Evaluation of surface structural and mechanical changes following remineralization of dentin, Scanning, 312
- Dai, 2011, Can Caries-Affected Dentin be Completely Remineralized by Guided Tissue Remineralization?, Dent Hypotheses, 74
- Pradeep, 2011, Remineralizing agents in the non-invasive treatment of early carious lesions, Int J Dent Case Rep, 73
- Ferguson, 2002, The persistent dry mouth, Contin Med Educ N Z Fam Physician, 1
- Aguiar, 2009, A review of the biological and clinical aspects of radiation caries, J Contemp Dent Pract, 83
- Badr, 2010, Protective effect of three different fluoride pretreatments on artificially induced dental erosion in primary and permanent teeth, J Am Sci, 442
- Ranjitkar S, Kaidonis JA, Roger SJ. "Gastroesophageal Reflux Disease and Tooth Erosion," International Journal of Dentistry, vol. 2012, Article ID 479850, p. 10, 2012. doi:10.1155/2012/479850. · DOI
- Karlinsey, 2009, In vitro evaluation of eroded enamel treated with fluoride and a prospective tricalcium phosphate agent, J Dent Oral Hygiene, 52
- Goswami, 2012, Latest developments in non-fluoridated remineralizing technologies, J Indian Soc Pedod Prev Dent, 2
- Chhabra, 2011, The beyond measures: Non flouride preventive measures for dental caries, J Int Oral Health, 1
- Singh M, Kaur M. Fluoride alternatives: A review of the present status. J Contemporary Dent Sci 1:54-61. Available from: http://www.nootandentalindia.org/journal-contents.html. [Last accessed on 2014 Aug 26].
- Walsh LJ. Contemporary technologies for remineralization therapies: A review. International Dentistry S Afr 11:6-16. Available from: http://www.moderndentistrymedia.com/nov_dec2009/walsh.pdf. [Last accessed on 2014 Aug 26].
- Al-Batayneh, 2009, The clinical applications of tooth moussetm and other CPP-ACP products in caries prevention: Evidence-based recommendations, Smile Dent J, 8
- Reynolds, 1997, Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions, J Dent Res, 1587
- Bussadori, 250;, Cytotoxicity assessment of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste, Conscientiae Sa, 354
- Cai, 2003, Remineralization of enamel subsurface lesions in situ by sugar-free lozenges containing casein phosphopeptide-amorphous calcium phosphate, Aust Dent J, 240
- Collins FM. Treatment options for tooth discoloration and remineralization. RDH 2008;28:1-11. doi: 02797720.
- Cochrane, 2010, New approaches to enhanced remineralization of tooth enamel, J Dent Res, 1187
- El, 2009, Combining casein phosphopeptide-amorphous calcium phosphate with fluoride: Synergistic remineralization potential of artificially demineralized enamel or not?, J Biomed Optics, 044039
- Kumar VL, Itthagarun A, King NM. The effect of casein phosphopeptide-amorphous calcium phosphate on remineralization of artificial caries-like lesions: An in vitro study. Aust Dent J 2008;53:34-40. doi: 10.1111/j.1834-7819.2007.00006.x. · DOI
- Oshiro, 2007, Effect of CPP-ACP paste on tooth mineralization: An FE-SEM study, J Oral Sci, 115
- Rose, 2000, Effects of an anticariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques, Arch Oral Biol, 569
- Shen, 2001, Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate, J Dent Res, 2066
- Shirahatti, 2007, The effects of three different pastes on enamel caries formation and lesion depth progression - An In Vitro Study, J Oral Health Comm Dent, 1
- Yimcharoen, 2011, The effect of casein phosphopeptide toothpaste versus fluoride toothpaste on remineralization of primary teeth enamel, Southeast Asian J Trop Med Public Health, 1032
- Vongsawan, 2010, The effect of high calcium milk and casein phosphopeptide-amorphous calcium phosphate on enamel erosion caused by cholinated water, Southeast Asian J Trop Med Public Health, 1494
- Zhao, 2011, Amorphous calcium phosphate and its application in dentistry, Chem Cent J, 40
- Reynolds, 2006, Casein phosphopeptide - amorphous calcium phosphate and the remineralization of enamel, US Dentistry, 51
- Dorozhkin, 2009, Nanodimensional and nanocrystalline apatites and other calcium orthophosphates in biomedical engineering, biology and medicine, Materials, 1975
- Tschoppe, 2009, Evaluation of the remineralising capacities of modified saliva substitutes in vitro, Arch Oral Biol, 810
- Lynch, 2011, Effects of zinc and fluoride on the remineralisation of artificial carious lesions under simulated plaque fluid conditions, Caries Res, 313
- George, 1992, The involvement of calcium phosphates in biological mineralization and demineralization processes, Pure Appl Chem, 1673
- Sullivan, 2001, Development of an enhanced anticaries efficacy dual component dentifrice containing sodium fluoride and dicalcium phosphate dihydrate, Am J Dent, 3A
- Roveri N, Battistella E, Bianchi CL, et al., "Surface Enamel Remineralization: Biomimetic Apatite Nanocrystals and Fluoride Ions Different Effects," Journal of Nanomaterials 2009, Article ID 746383 doi:10.1155/2009/746383. · DOI
- Roveri, 2008, Synthetic biomimetic carbonate-hydroxyapatite nanocrystals for enamel remineralization, Adv Mater Res Vols, 821
- Tschoppe, 2011, Enamel and dentine remineralization by nano-hydroxyapatite toothpastes, J Dent, 430
- Roveri, 2009, Recent advancements in preventing teeth health hazard: The daily use of hydroxyapatite instead of fluoride, Recent Pat Biomed Eng, 197
- Huang, 2009, Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro, Biomed Mater, 034104
- King, 2006, Remineralization by nanohydroxyapatite-containing dentifrice: A pH cycling study using slurry, J Dent Res, 000
- Itthagarun, 2006, Remineralization effects of nanohydroxyapatite-containing dentifrice: A pH-cycling study using supernatant, J Dent Res, 000
- Haghgoo, 2011, Evaluation of the effect of nanohydroxyapatite on erosive lesions of the enamel of permanent teeth following exposure to soft beer in vitro, Sci Res Essays, 5933
- Nakashima, 2009, Effect of a test dentifrice containing nano-sized calcium carbonate on remineralization of enamel lesions in vitro, J Oral Sci, 69
- Madan, 2011, Tooth remineralization using bio-active glass - A novel approach, J Acad Adv Dent Res, 45
- Vahid, 2012, Remineralization Effect of Topical NovaMin Versus Sodium Fluoride (1.1%) on Caries-Like Lesions in Permanent Teeth, J Dent (Tehran), 68
- Stone, 2008, Enhanced enamel fluoride uptake from NovaMin® - Containing fluoride dentifrices, J Dent Res, 0625
- Wefel JS. NovaMin: Likely clinical success. Adv Dent Res 2009;21:40-3. · DOI
- Mason, 2009, New In Vitro and In Situ evidence for a toothpaste formulated for those at risk from erosive tooth wear, J Clin Dent, 175
- Jaidka, 2012, The Effect of prevident and pronamel in the prevention of chemical erosion: A comparative study, Indian J Stomatol, 102
- Poggio, 2010, Impact of two toothpastes on repairing enamel erosion produced by a soft drink: An AFM in vitro study, J Dent, 868
- Acevedo, 2008, Clinical evaluation of the ability of CaviStat® in a mint confection to inhibit the development of dental caries in children, J Clin Dent, 1
- Rirattanapong, 2011, Effect of five different dental products on surface hardness of enamel exposed to chlorinated water in vitro, Southeast Asian J Trop Med Public Health, 1293
- Su, 2011, Caries prevention for patients with dry mouth, J Can Dent Assoc, b85
- Rirattanapong, 2011, Effect of various forms of calcium in dental products on human enamel microhardness in vitro, Southeast Asian J Trop Med Public Health, 1056
- Karlinsey, 2009, In vitro remineralization efficacy of NaF systems containing unique forms of calcium, Am J Dent, 185
- Delbem, 2010, Anticaries effect of dentifrices with calcium citrate and sodium trimetaphosphate, J Appl Oral Sci, 94
- Skrtic, 2002, Silica- and zirconia-hybridized amorphous calcium phosphate: Effect on transformation to hydroxyapatite, J Biomed Mater Res, 597
- Qi, 2012, Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate, Acta Biomater, 836
- Rethman MP, Beltrán-Aguilar ED, Billings RJ, Burne RA, Clark M, Donly KJ, et al. Non-fluoride caries preventive agents. Full report of a systematic review and evidence-based recommendations. ADA Center for Evidence Based Dentistry; 2011. Available from: http://www.ada.org › ADA News › Media Resources › Press Releases. [Last accessed on 2012 Jul 25].
- Yamamotoa, 2010, Antibacterial characteristics of CaCO3-MgO composites, Mater Sci Eng, 208
- Featherstone, 2006, Delivery challenges for fluoride, chlorhexidine and xylitol, BMC Oral Health, S8
Cited by
Sorted by citations
Baidya, D., Pathivada, L., Garg, N., Karthik, K. M., Jain, A. K., & Bhyri, P. (2026) · International Journal of Clinical Pediatric Dentistry · doi:10.5005/jp-journals-10005-3470
Metadata
- Authors
- Kalra, D., Kalra, R., Kini, P., & Allama Prabhu, C.
- Venue
- Journal of Dental and Allied Sciences
- Publisher
- Medknow
- Published
- 2014
- Volume
- 3
- Issue
- 1
- Pages
- 24
- ISSN
- 2277-4696
- Cited by
- 26
- References
- 0
- Language
- en
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