Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 2

The DOI matches its Crossref record.

Evaluation of the Effect of Vitamin D Treatment on Cardiac Function in Non-Obese Female Adolescents with Vitamin D Deficiency in Türkiye: A Cross-Sectional Study

Altın, H, Şen, E, Bozdemir, ŞE, Türe, E, Aktürk, B, Karaca, A·2024·Nigerian Journal of Clinical Practice
DOI 10.4103/njcp.njcp_721_23
Open this paper in CoChat — free account

Abstract

A BSTRACT: Background: Vitamin D deficiency may cause adverse effects on the cardiovascular system as well as many other systems. The risk of vitamin D deficiency increases during adolescence, when the growth rate is high, due to reasons such as limited sun exposure, inadequate dietary calcium, and vitamin D intake. Aim: To evaluate the effect of daily 2000 IU vitamin D supplementation for 12 weeks on cardiac function in non-obese adolescent girls with vitamin D deficiency. Methods: This cross-sectional study was carried out between September 2021 and June 2022. A total of 108 non-obese adolescent girls having 25-hydroxyvitamin D [25(OH)D] levels below 12 ng/mL were given daily 2000 IU vitamin D orally for 12 weeks. Serum levels of 25(OH)D, alkaline phosphatase, parathormone, calcium, phosphate, and cardiac function were determined before and after treatment. Results: After treatment, the 25(OH)D levels were above 20 ng/mL in 90.8% of the adolescents. The parathormone and alkaline phosphatase levels decreased, while the phosphate levels increased. Echocardiographic tissue Doppler studies showed positive changes in some systolic and diastolic function indicators. In addition, the myocardial performance index decreased from 0.42 ± 0.03 to 0.40 ± 0.03 ( P < 0.001) in the left ventricle, from 0.43 ± 0.03 to 0.38 ± 0.03 ( P < 0.001) in the right ventricle, and from 0.41 ± 0.04 to 0.38 ± 0.02 ( P < 0.001) in the interventricular septum after vitamin D treatment as compared to pretreatment. Conclusion: It was observed that administration of 2000 IU vitamin D treatment for a period of 12 weeks to non-obese adolescent girls with vitamin D deficiency contributed positively to cardiac systolic and diastolic function.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4103/njcp.njcp_721_23

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 37

  1. Silva, 2022, Vitamin D metabolism and extraskeletal outcomes:An update, Arch Endocrinol Metab, 66, 748, 10.20945/2359-3997000000565 · DOI
  2. Daniel, 2022, Vitamin D deficiency and cardiometabolic risk factors in adolescents:Systematic review and meta-analysis, Rev Endocr Metab Disord, 23, 995, 10.1007/s11154-022-09736-7 · DOI
  3. Hung, 2023, The role of vitamin D in cardiovascular diseases, Nutrients, 15, 3547, 10.3390/nu15163547 · DOI
  4. Chen, 2011, Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy, Circulation, 124, 1838, 10.1161/CIRCULATIONAHA.111.032680 · DOI · Paper page
  5. Latic, 2022, Interaction of Vitamin D with peptide hormones with emphasis on parathyroid hormone, FGF23, and the renin-angiotensin-aldosterone system, Nutrients, 14, 5186, 10.3390/nu14235186 · DOI
  6. Alsufiani, 2022, A single Vitamin D3 bolus supplementation ımproves Vitamin D status and reduces proinflammatory cytokines in healthy females, Nutrients, 14, 3963, 10.3390/nu14193963 · DOI
  7. Komisarenko, 2018, Vitamin D deficiency and ımmune disorders in combined endocrine pathology, Front Endocrinol (Lausanne), 9, 600, 10.3389/fendo.2018.00600 · DOI
  8. Schleithoff, 2006, Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure:A double-blind, randomized, placebo-controlled trial, Am J Clin Nutr, 83, 754, 10.1093/ajcn/83.4.754 · DOI · Paper page
  9. Wolters, 2023, Longitudinal associations between vitamin D status and cardiometabolic risk markers among children and adolescents, J Clin Endocrinol Metab, 108, e1731, 10.1210/clinem/dgad310 · DOI
  10. Munns, 2016, Global consensus recommendations on prevention and management of nutritional rickets, Horm Res Paediatr, 85, 83, 10.1159/000443136 · DOI · Paper page
  11. Holick, 2011, Evaluation, treatment, and prevention of vitamin D deficiency:An Endocrine Society clinical practice guideline, J Clin Endocrinol Metab, 96, 1911, 10.1210/jc.2011-0385 · DOI · Paper page
  12. Metwalley, 2016, Evaluation of some cardiac functions among children with vitamin D deficiency rickets, Ann Circ, 1, 007, 10.17352/ac.000002 · DOI
  13. Hacıoğlu, 2018, Impaired cardiac functions and aortic elastic properties in patients with severe vitamin D deficiency, J Cardiovasc Echogr, 28, 171, 10.4103/jcecho.jcecho_82_17 · DOI
  14. Uysal, 1999, Cardiac functions in children with vitamin D deficiency rickets, Pediatr Cardiol, 20, 283, 10.1007/s002469900464 · DOI
  15. Chunbin, 2020, Efficacy of Vitamin D on chronic heart failure among adults, Int J Vitam Nutr Res, 90, 49, 10.1024/0300-9831/a000487 · DOI
  16. Yeşiltepe-Mutlu, 2020, Vitamin D status across age groups in Turkey:Results of 108,742 samples from a single laboratory, J Clin Res Pediatr Endocrinol, 12, 248, 10.4274/jcrpe.galenos.2019.2019.0097 · DOI
  17. Neyzi, 2015, Reference values for weight, height, head circumference, and body mass ındex in Turkish children, J Clin Res Pediatr Endocrinol, 7, 280, 10.4274/jcrpe.2183 · DOI
  18. Keskinoglu, 2020, Blood pressure percentiles in Turkish Children and adolescents, J Pediatr Res, 7, 279, 10.4274/jpr.galenos.2019.48030 · DOI
  19. Lang, 2015, Recommendations for cardiac chamber quantification by echocardiography in adults:An update from the American Society of Echocardiography and the European Association of cardiovascular ımaging, J Am Soc Echocardiogr, 28, 1, 10.1016/j.echo.2014.10.003 · DOI · Paper page
  20. Askin, 2023, Myocardial performance index and cardiovascular diseases, Echocardiography, 40, 720, 10.1111/echo.15628 · DOI
  21. Kumaratne, 2020, Treatment with Vitamin D3 in Vitamin D deficient adolescents:A pilot study, Glob Pediatr Health, 7, 1
  22. Bilici, 2019, The effect of 2000 ıu/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents, Turk J Pediatr, 61, 723, 10.24953/turkjped.2019.05.011 · DOI
  23. Rajakumar, 2016, Estimations of dietary vitamin D requirements in black and white children, Pediatr Res, 80, 14, 10.1038/pr.2016.46 · DOI
  24. Jensen, 2023, Latest knowledge on the role of Vitamin D in hypertension, Int J Mol Sci, 24, 4679, 10.3390/ijms24054679 · DOI
  25. Schlüter, 1995, Parathyroid hormone induces protein kinase C but not adenylate cyclase in adult cardiomyocytes and regulates cyclic AMP levels via protein kinase C-dependent phosphodiesterase activity, Biochem J, 310, 439, 10.1042/bj3100439 · DOI
  26. Purra, 2022, Cardiac structural and functional abnormalities in primary hyperparathyroidism, J Endocrinol Invest, 45, 327, 10.1007/s40618-021-01645-x · DOI
  27. Ameri, 2013, Relationship between vitamin D status and left ventricular geometry in a healthy population:Results from the Baltimore Longitudinal Study of Aging, J Intern Med, 273, 253, 10.1111/joim.12007 · DOI
  28. Weber, 2009, Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium, Cardiovasc Res, 81, 500, 10.1093/cvr/cvn261 · DOI
  29. Nizami, 2019, Vitamin D deficiency in rats causes cardiac dysfunction by ınducing myocardial ınsulin resistance, Mol Nutr Food Res, 63, e1900109, 10.1002/mnfr.201900109 · DOI
  30. Pál, 2023, Role of Vitamin D deficiency in the pathogenesis of cardiovascular and cerebrovascular diseases, Nutrients, 15, 334, 10.3390/nu15020334 · DOI
  31. Hassanzadeh-Makoui, 2020, Effects of Vitamin D on left ventricular ejection fraction in patients with systolic heart failure:A Double-Blind randomized clinical trial, Int J Endocrinol Metab, 18, e103528, 10.5812/ijem.103528 · DOI
  32. Matter, 2016, Myocardial function in Saudi adolescents with vitamin D deficiency:Tissue Doppler imaging study, J Saudi Heart Assoc, 28, 22, 10.1016/j.jsha.2015.06.006 · DOI
  33. Gökalp, 2022, Effect of vitamin D on myocardial remodeling and inflammatory status in children with congenital heart disease, Turk J Med Sci, 52, 1900, 10.55730/1300-0144.5537 · DOI
  34. Meems, 2011, Vitamin D biology in heart failure:Molecular mechanisms and systematic review, Curr Drug Targets, 12, 29, 10.2174/138945011793591554 · DOI
  35. Xiu, 2021, Correlation Between 25-Hydroxyvitamin D Level and cardiac diastolic dysfunction in chinese adults with early-onset Type 2 diabetes mellitus:A Cross-sectional study, Diabetes Metab Syndr Obes, 14, 1823, 10.2147/DMSO.S299422 · DOI
  36. Patange, 2013, Vitamin D deficiency is associated with increased left ventricular mass and diastolic dysfunction in children with chronic kidney disease, Pediatr Cardiol, 34, 536, 10.1007/s00246-012-0489-z · DOI
  37. Eisner, 2020, The control of diastolic calcium in the heart:Basic mechanisms and functional implications, Circ Res, 126, 395, 10.1161/CIRCRESAHA.119.315891 · DOI

Cited by

Metadata

Authors
Altın, H., Şen, E., Bozdemir, Ş., Türe, E., Aktürk, B., & Karaca, A.
Affiliations
  • Department of Pediatric Cardiology, Bursa Medical Faculty, Bursa City Hospital, Bursa, Turkey
  • Department of Pediatrics, Bursa City Hospital, Bursa, Turkey
  • Department of Pediatric Infectious Diseases, Bursa Medical Faculty, Bursa City Hospital, Bursa, Turkey
  • Department of Pediatric Emergency Diseases, University of Healty Science, Bursa Medical Faculty, Bursa City Hospital, Bursa, Turkey
Venue
Nigerian Journal of Clinical Practice
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2024-02
Volume
27
Issue
2
Pages
194-201
ISSN
  • 1119-3077
  • 2229-7731
DOI
10.4103/njcp.njcp_721_23
Cited by
2
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.