The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Use of Epigenetic Drugs in Disease: An Overview
Open accessAbstract
Epigenetic changes such as DNA methylation and histone methylation and acetylation alter gene expression at the level of transcription by upregulating, downregulating, or silencing genes completely. Dysregulation of epigenetic events can be pathological, leading to cardiovascular disease, neurological disorders, metabolic disorders, and cancer development. Therefore, identifying drugs that inhibit these epigenetic changes are of great clinical interest. In this review, we summarize the epigenetic events associated with different disorders and diseases including cardiovascular, neurological, and metabolic disorders, and cancer. Knowledge of the specific epigenetic changes associated with these types of diseases facilitates the development of specific inhibitors, which can be used as epigenetic drugs. In this review, we discuss the major classes of epigenetic drugs currently in use, such as DNA methylation inhibiting drugs, bromodomain inhibitors, histone acetyl transferase inhibitors, histone deacetylase inhibitors, protein methyltransferase inhibitors, and histone methylation inhibitors and their role in reversing epigenetic changes and treating disease.
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Cites
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Self-citationIn vivo target gene activation via CRISPR/Cas9-mediated trans-epigenetic modulation
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Challenges and Opportunities in Cancer Drug Resistance
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New Targets for Schizophrenia Treatment beyond the Dopamine Hypothesis
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A cellular and molecular view of T helper 17 cell plasticity in autoimmunity
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Metadata
- Authors
- Heerboth, S., Lapinska, K., Snyder, N., Leary, M., Rollinson, S., & Sarkar, S.
- Venue
- Genetics & Epigenetics
- Publisher
- SAGE Publications
- Published
- 2014-01
- Volume
- 6
- Pages
- 9-19
- ISSN
- 1179-237X (ISSN-L)
- OpenAlex
- W2071100938
- Cited by
- 326
- References
- 122
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Heerboth, S., Lapinska, K., Snyder, N., Leary, M., Rollinson, S., & Sarkar, S. (2014). Use of Epigenetic Drugs in Disease: An Overview. Genetics & Epigenetics. https://doi.org/10.4137/geg.s12270
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
