Synthetic and natural iron chelators: Therapeutic potential and clinical use

Hatcher, Heather C, Singh, Ravi N, Torti, Frank M, Torti, Suzy V·2009·Future Medicinal Chemistry

Cited by (241)

Items 201–241 of 241

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  3. Synthesis and Characterization of 3-Hydroxy-2-(5'-Hydroxypentyl)-4H-Pyran-4-one and Study of Its Complexation with Iron(III)
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  4. Deferoxamine and other iron chelators
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  5. Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
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  6. Alleviation of Hepatotoxicity by Natural Chelators in Lead-induced Poisoning in Rats
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  7. Antioxidant Activity and Phytochemicals of Locally Consumed Plant Foods from Baguio City, Philippines
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  8. Manuka combinations with nigella sativa and hydroxyurea in treating iron overload of pediatric β-thalassemia major, randomized clinical trial
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  9. Combination Disease‐Modifying Therapy for Neurodegenerative Diseases Using Repurposed Drugs
    Alexander Shtilbans, Anthony Edward Lang · 2026 · Annals of Neurology
  10. Deferoxamine Attenuates Seizure Stages, Oxidative Stress, and Apoptosis via Iron Chelation in a PTZ-Induced Epilepsy Model
    Arzuhan ÇETİNDAĞ ÇİLTAŞ, Levent Hacısüleyman · 2026 · Neurochemical Journal
  11. Herbal Neurotherapeutics for Cognitive Disorders: Integrative Mechanisms Linking Neurotransmitter Systems, Neurodegeneration, and the Gut-Brain Axis
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  12. Synthesis of 3-hydroxy-4-pyridinone hexadentate chelators, and biophysical evaluation of their affinity towards lipid bilayers
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  13. Chemistry and Biomedical Applications of Fungal Siderophores
    Mohamed Saleem Abdul Shukkoor, Shaik Ibrahim Khalivulla · 2021 · Fungal biology
  14. Evaluation of Beneficial Effects of Melilotus officinalis on Blood Profiles in iron Overloaded Sprague Dawley Rats
    N.A. Sheikh, Satish Bhaskar Kosalge, Tusharbindu R. Desai, Anil P. Dewani, Deepak Mohale, Alok Shiomurti Tripathi · 2020 · Journal of Hematology Research
  15. Pharmacokinetic characterization and modeling of a deferoxamine-based nanochelator in rats
    Gregory Jones · 2022
  16. Transferrin Receptor 1 is Required for CD4+ T Cell Iron-Dependent Response During Acute Toxoplasma gondii Infection
    Stephen L. Denton, Tathagato Roy, Hunter K. Keplinger, Sai K. Ng, Jason P. Gigley · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
    Vera Vollenweider, Karoline Rehm, Clara Chepkirui, Manuela Pérez‐Berlanga, Magdalini Polymenidou, Jörn Piel, Laurent Bigler, Rolf Kümmerli · 2024 · eLife
  18. Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
    Vera Vollenweider, Karoline Rehm, Clara Chepkirui, Manuela Pérez‐Berlanga, Magdalini Polymenidou, Jörn Piel, Laurent Bigler, Rolf Kümmerli · 2024 · eLife
  19. Are Calcium Channels More Important Than Calcium Influx for Cell Proliferation?
    Anne‐Sophie Borowiec, Gabriel Bidaux, Thierry Capiod · 2013 · Springer eBooks
  20. A Mini-Review on Iron Chelating Agents as a Promising Therapeutic Target in Treatment of Leishmaniasis
    Mahdi Fakhar, Mohammad Azadbakht, Ali Davoodi, Shahram Eslami, Hajar Ziaei Hezarjaribi, Masoud Keighobadi · 2020 · DOAJ (DOAJ: Directory of Open Access Journals)
  21. A Summary on Up-To-Date Research on Fungal Siderophores on Disease, Treatment and Pathogenicity Based on Text Mining, Bioinformatics and Experts’ Opinion
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  23. Biochemical, Biophysical and Functional Characterization of an Insoluble Iron Containing Hepcidin–Ferritin Chimeric Monomer Assembled Together with Human Ferritin H/L Chains at Different Molar Ratios
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  24. Exploring the Molecular Mechanisms of Action of Samoan Medicinal Plants via Chemical Genetic Analyses
    Seeseei Molimau-Samasoni · 2016
  25. Investigation of Mitochondrial Transfer between Human Erythroblasts
    Brittany Lewer · 2019
  26. Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma
    Egarit Noulsri, Surada Lerdwana · 2022 · Medical Hypotheses
  27. Evaluation of beneficial effects of Epilobium hirsutum on hematological parameter in iron intoxicated Sprague–Dawley rats
    Naheed Waseem A. Sheikh, Satish Bhaskar Kosalge, Tusharbindu R. Desai, Anil P. Dewani, Deepak Mohale, Alok Shiomurti Tripathi · 2022 · Journal of Hematology and Allied Sciences
  28. A review on therapeutic use of iron in cancer treatment
    Yadvender, Gurmeet Kaur · 2024 · AIP conference proceedings
  29. Green decontaminants for the remediation of chemical, biological, radiological and nuclear contaminants
    Pooja Yadav, Raman Chawla, Varnika Khattar, Ashrit Nair, Bhupendra Singh Butola, Navneet Sharma, Haider Ali Khan · 2025 · Phytochemistry Reviews
  30. Design of nanocarriers for hexadentate 3,4-hydroxypyridinone chelators: A macrophage-targeted strategy to address intracellular infections
    Sílvia Vinhas, Tânia Moniz, Andreia Granja, Baltazar de Castro, Salette Reis, Maria Rangel · 2025 · Journal of Drug Delivery Science and Technology
  31. Small molecule inhibitors of HG-induced VEC ferroptosis: synthetic advances and therapeutic applications
    Yu-Xi Zheng, Ning Meng, Cheng‐Shi Jiang · 2025 · Future Medicinal Chemistry
  32. Phytochemicals in tribal food and medicine
    Selva Kumar T, Aminu Abdullahi, Rajiv Periakaruppan, Priyadharshini Eswaran, Gowtham Shanmugam · 2025 · Elsevier eBooks
  33. Molecular docking approaches in mycetoma: Toward improved patient management
    Ali Awadallah Saeed, Marwa Salah S. Osman, Ahmed Hassan Fahal · 2026 · PLoS neglected tropical diseases
  34. Protective effects of propolis against bisphenol a-induced hepatorenal toxicity in male rats: an experimental study
    Nehal H. Ali, Heba Nageh Gad El-Hak, Zohour Ibrahim Nabil, Ghada M. Abd Elghany · 2026 · Beni-Suef University Journal of Basic and Applied Sciences
  35. Role of endolysosome iron in amyloid-β protein-induced increases in reactive oxygen species, mitochondrial depolarization, and cytotoxicity
    D. Quansah, P. Halcrow, Nirmal Kumar, Braelyn Liang, Jonathan D. Geiger · 2026 · Journal of Alzheimer's Disease
  36. Quantitative structure–activity relationship (QSAR) investigation of isonicotinamide derivatives as GSK-3β inhibitors using DFT based quantum descriptors for Alzheimer’s disease
    Sarthak J. Trivedi, Sutapa Mondal Roy, Debesh Ranjan Roy · 2026 · Interactions
  37. Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth
    Hong Wang, Jiawei Liu, Xintao Yang, Mohamad Koohi‐Moghadam, Shuting Gao, Yuanyuan Han, Dineshi Sewvandi Thalakiriyawa, James Kit Hon Tsoi, Yanqi Yang, Waruna Lakmal Dissanayaka · 2026 · International Endodontic Journal
  38. Ferroptosis in Radiation Pneumonitis: Mechanisms and Advances in Interventions Combining Traditional Chinese and Western Medicine
    培艳 曾 · 2026 · Traditional Chinese Medicine
  39. Fine-tuning thiosemicarbazones with heterocyclic substituents: identification of styryl-dependent cysteine reactivity and potent anti-cancer activity
    Tharushi P. Wijesinghe, Mahendiran Dharmasivam, Büşra Kaya, Paul V. Bernhardt, Masnun Naher, Des Raymond Richardson · 2026 · Chemical Science
  40. BindingDB Entry 50047920: Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease.
    BindingDB · 2018 · UC San Diego
  41. BindingDB Entry 50012329: Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.
    BindingDB · 2022 · UC San Diego