The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Structural Insights into G-Quadruplexes: Towards New Anticancer Drugs
Open accessAbstract
DNA G-quadruplexes are DNA secondary structures formed in specific G-rich sequences. DNA sequences that can form G-quadruplexes have been found in regions with biological significance, such as human telomeres and oncogene-promoter regions. DNA G-quadruplexes have recently emerged as a new class of novel molecular targets for anticancer drugs. Recent progress on structural studies of the biologically relevant G-quadruplexes formed in human telomeres and in the promoter regions of human oncogenes will be discussed, as well as recent advances in the design and development of G-quadruplex-interactive drugs. DNA G-quadruplexes can readily form in solution under physiological conditions and are globularly folded nucleic acid structures. The molecular structures of intramolecular G-quadruplexes appear to differ from one another and, therefore, in principle may be differentially regulated and targeted by different proteins and drugs.
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Cites
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Cited by
Dai, J., Carver, M., Hurley, L. H., & Yang, D. (2011) · Journal of the American Chemical Society · doi:10.1021/ja205646q · Cited by 381
Self-citationHu, M.-H., Wang, Y.-Q., Yu, Z.-Y., Hu, L.-N., Ou, T.-M., Chen, S.-B., Huang, Z.-S., & Tan, J.-H. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01697 · Cited by 101
Metadata
- Authors
- Yang, D., & Okamoto, K.
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2010-04
- Volume
- 2
- Issue
- 4
- Pages
- 619-646
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W2143583668
- Cited by
- 322
- References
- 14
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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