Nitric Oxide Therapy for Dermatologic Disease
Open accessAbstract
Nitric oxide (NO) plays an important role in the maintenance and regulation of the skin and the integrity of its environment. Derangement of NO production is implicated in the etiology of a multitude of dermatologic diseases, indicating future therapeutic directions. In an era of increasing resistance rates to available antibiotics and subpar development of new agents, NO is promising as a prospective topical broad-spectrum antimicrobial agent with small likelihood of resistance development. Because the greatest strides have been made in the setting of infectious disease and skin and soft-tissue infection, this will be a major focus of this article. In addition, we will review NO's role in skin regulation and dysregulation, immune function, the various topical release systems that have been devised and tested, NO's relation to UV radiation and skin pigmentation, and finally, its potential applications as a cosmeceutical.
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NO has been evaluated as a therapy in a variety of bacterial and fungal infections, including infections by Pseudomonas aeruginosa in cases of cystic fibrosis and infections caused by dermatophytes.
“NO has been evaluated as a therapy in a variety of bacterial and fungal infections, including infections by Pseudomonas aeruginosa in cases of cystic fibrosis and infections caused by dermatophytes (22–24).”
From Inhibition of Classical and Alternative Modes of Respiration in <i>Candida albicans</i> Leads to Cell Wall Remodeling and Increased Macrophage Recognition (2019) · cites this paper as [23]
The section on skin and soft-tissue infection reports in vitro activity of NO-releasing preparations against P. aeruginosa, and Table 1 lists activity against Trichophyton species and tinea pedis. The References identify P. aeruginosa as a cystic-fibrosis pathogen studied under laboratory conditions, but the paper does not establish that NO was evaluated to treat infections in people with cystic fibrosis. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn the skin, •NO provides a protective barrier against micro-organisms and regulates melanogenesis and the formation of erythema that can occur from exposure to ultraviolet UV light.
“In the skin, •NO provides a protective barrier against micro-organisms, and regulates melanogenesis and the formation of erythema that can occur from exposure to ultraviolet UV light [120].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [120]
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References 62 · Cited by 43
- Authors
- Adler, B. L., & Friedman, A. J.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Friedman, Adam J
- Venue
- Future Science OA
- Publisher
- Informa UK Limited
- Published
- 2015-07-27
- Volume
- 1
- Issue
- 1
- Pages
- FSO37-FSO37
- ISSN
- 2056-5623 (ISSN-L)
- PMC
- PMC5137922
- OpenAlex
- W2183838214
- Cited by
- 43
- References
- 62
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 4
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Future Science OA (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- nitric oxide, nitric oxide therapy, skin diseases, topical antimicrobial agents, antibiotic resistance, skin and soft tissue infections, immune function, topical drug delivery systems, ultraviolet radiation, skin pigmentation, cosmeceuticals
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