CoChat
Sign Up
Cited by 508Hyperglycemia and glycemic control in critically ill and hospitalized patientsAdrenal Hormones and DisordersDiabetes Treatment and Management

Glucocorticoid-induced hyperglycemia

Clore, John N., Thurby-Hay, Linda·2009·Endocrine Practice
DOI 10.4158/ep08331.rar
Open this paper in CoChat — free account

Abstract

Objective To review the current literature on glucocorticoid-induced hyperglycemia and provide a strategy for its treatment.Methods We undertook an electronic (MEDLINE) and a library review of the existing pertinent literature published from 1950 to March 2009.Results Glucocorticoid-induced hyperglycemia is common in patients with and without diabetes. The odds ratio for new-onset diabetes mellitus in patients treated with glucocorticoids ranges from approximately 1.5 to 2.5. Total glucocorticoid dose and duration of therapy are strong predictors of diabetes induction. Other risk factors include age and body mass index. Failure to treat glucocorticoid-induced hyperglycemia is related to the presumed short duration of administration of glucocorticoid treatment and the emphasis on fasting plasma glucose only. Understanding the pharmacodynamics of glucocorticoids can lead to increased recognition and improved treatment of the condition. Recent demonstrations that even shortterm elevations in blood glucose level may be associated with adverse sequelae argue for greater attention to the condition.Conclusion Glucocorticoid-induced hyperglycemia is an important clinical finding that, if recognized, can be effectively treated. We propose a relatively simple schema for the proactive management of corticosteroid-induced hyperglycemia that has been effective and easily adaptable to both the inpatient and the outpatient setting.

Integrity signals

Registry

Crossref · 10.4158/ep08331.rar

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • This observation is in line with previous studies reporting large postprandial glucose excursions with only modest changes in fasting glucose levels.

    “This observation is in line with previous studies reporting large postprandial glucose excursions with only modest changes in fasting glucose levels [19, 26].”

    From Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial (2011) · cites this paper as [26]

  • Patients with long-term cortisol excess, as seen in Cushing syndrome, and patients treated with glucocorticoids often have increased susceptibility to hyperglycaemia and manifest diabetes mellitus.

    “Patients with long-term cortisol excess, as seen in those with Cushing syndrome 24 , and patients treated with glucocorticoids often have increased susceptibility to hyperglycaemia and manifest diabetes mellitus 25 .”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [25]

  • Glucocorticoid-induced hyperglycemia or diabetes is a common complication.

    “GC-induced hyperglycemia or DM is nonetheless a common complication (-), and there are reports of a dose-dependent increase in the risk of developing DM requiring hypoglycemic therapy ().”

    From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [195]

  • A recent meta-analysis found an odds ratio of 1.5 to 2.5 for newly diagnosed diabetes in patients taking exogenous glucocorticoids.

    “A recent meta-analysis revealed an odds ratio of . to . for newly diagnosed DM in patients taking exogenous GCs; measuring FPG level may underestimate the disease compared with a glucose tolerance test ().”

    From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [195]

  • Measuring fasting plasma glucose may underestimate diabetes compared with a glucose tolerance test.

    “A recent meta-analysis revealed an odds ratio of . to . for newly diagnosed DM in patients taking exogenous GCs; measuring FPG level may underestimate the disease compared with a glucose tolerance test ().”

    From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [195]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Clore, J. N., & Thurby-Hay, L.
Affiliations
Virginia Commonwealth University (US)
Corresponding author
Clore, John N.
Venue
Endocrine Practice
Publisher
Elsevier BV
Published
2009-07
Volume
15
Issue
5
Pages
469-474
ISSN
1530-891X (ISSN-L)
DOI
10.4158/ep08331.rar
OpenAlex
W2057624928
Cited by
508
References
39
Citations by year
2026: 34 · 2025: 29 · 2024: 32 · 2023: 40 · 2022: 37 · 2021: 46 · 2020: 29 · 2019: 34 · 2018: 31 · 2017: 26 · 2016: 19 · 2015: 25 · 2014: 22 · 2013: 33 · 2012: 26
FWCI
3.11
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Endocrine Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
glucocorticoid-induced hyperglycemia, corticosteroid-induced diabetes, new-onset diabetes, risk factors, fasting blood glucose, hyperglycemia management, body mass index, age
MeSH terms
Glucocorticoids, Humans, Hyperglycemia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review