The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Blood cells and endothelial barrier function
Open accessAbstract
The barrier properties of endothelial cells are critical for the maintenance of water and protein balance between the intravascular and extravascular compartments. An impairment of endothelial barrier function has been implicated in the genesis and/or progression of a variety of pathological conditions, including pulmonary edema, ischemic stroke, neurodegenerative disorders, angioedema, sepsis and cancer. The altered barrier function in these conditions is often linked to the release of soluble mediators from resident cells (e.g., mast cells, macrophages) and/or recruited blood cells. The interaction of the mediators with receptors expressed on the surface of endothelial cells diminishes barrier function either by altering the expression of adhesive proteins in the inter-endothelial junctions, by altering the organization of the cytoskeleton, or both. Reactive oxygen species (ROS), proteolytic enzymes (e.g., matrix metalloproteinase, elastase), oncostatin M, and VEGF are part of a long list of mediators that have been implicated in endothelial barrier failure. In this review, we address the role of blood borne cells, including, neutrophils, lymphocytes, monocytes, and platelets, in the regulation of endothelial barrier function in health and disease. Attention is also devoted to new targets for therapeutic intervention in disease states with morbidity and mortality related to endothelial barrier dysfunction.
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Cites
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
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Pericytes regulate the blood–brain barrier
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Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
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“The cerebral vasculature contains an additional component of the endothelial barrier called tight junctions (TJ), which closely fuses adjacent endothelial cells and further restricts the exchange of fluid and solutes through the paracellular spaces.(24,25) TJ contribute to the highly selective properties of the blood…”
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The Role of Wnt Signaling in Physiological and Pathological Angiogenesis
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Cited by
Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498
Blood-brain barrier dysfunction and recovery after ischemic stroke
Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 936
Turner, R. J., & Sharp, F. R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00056 · Cited by 533
Contribution of Angiogenesis to Inflammation and Cancer
Aguilar-Cazares, D., Chavez-Dominguez, R., Carlos-Reyes, A., Lopez-Camarillo, C., Hernadez de la Cruz, O. N., & Lopez-Gonzalez, J. S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01399 · Cited by 317
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilic, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 286
Metadata
- Authors
- Rodrigues, S. F., & Granger, D. N.
- Venue
- Tissue Barriers
- Publisher
- Informa UK Limited
- Published
- 2015-01-14
- Volume
- 3
- Issue
- 1-2
- Pages
- e978720
- ISSN
- 2168-8362 (ISSN-L)
- 2168-8370
- OpenAlex
- W2076485284
- Cited by
- 284
- References
- 13
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
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