The DOI matches its Crossref record.
Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair
Open accessAbstract
Increased numbers of autophagosomes/autophagic vacuoles are seen in a variety of physiological and pathological states in the nervous system. In many cases, it is unclear if this phenomenon is the result of increased autophagic activity or decreased autophagosome-lysosome fusion. The functional significance of autophagy and its relationship to cell death in the nervous system is also poorly understood. In this review, we have considered these issues in the context of acute neuronal injury and a range of chronic neurodegenerative conditions, including the Lurcher mouse, Alzheimer's, Parkinson's, Huntington's and prion diseases. While many issues remain unresolved, these conditions raise the possibility that autophagy can have either deleterious or protective effects depending on the specific situation and stage in the pathological process.
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Citations
Cited by
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
The machinery of macroautophagy
Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083
Tanida, I., Ueno, T., & Kominami, E. (2008) · Methods in Molecular Biology™ · doi:10.1007/978-1-59745-157-4_4 · Cited by 1,785
Boland, B., Kumar, A., Lee, S., Platt, F. M., Wegiel, J., Yu, W. H., & Nixon, R. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-08.2008 · Cited by 1,119
Self-citationMacroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505082 · Cited by 967
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Metadata
- Authors
- Rubinsztein, D. C., DiFiglia, M., Heintz, N., Nixon, R. A., Qin, Z.-H., Ravikumar, B., Stefanis, L., & Tolkovsky, A.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2005-04-28
- Volume
- 1
- Issue
- 1
- Pages
- 11-22
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W1990586782
- Cited by
- 423
- References
- 0
- FWCI
- 18.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rubinsztein, D. C., DiFiglia, M., Heintz, N., Nixon, R. A., Qin, Z.-H., Ravikumar, B., Stefanis, L., & Tolkovsky, A. (2005). Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy. https://doi.org/10.4161/auto.1.1.1513
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
