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Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
Open accessAbstract
Cathepsins have long been considered as housekeeping molecules. However, specific functions have also been attributed to each of these lysosomal proteases. Squamous cell carcinoma antigen (SCCA) 1, widely expressed in various uterine cervical cells, is an endogenous cathepsin (cat) L inhibitor. In this study, we investigated whether the cat L-SCCA 1 lysosomal pathway and autophagy were involved in resveratrol (RSV)-induced cytotoxicity in cervical cancer cells. RSV induced GFP-LC3 aggregation as well as increased the presence of LC3-II and autophagosomes as was revealed by electron microscopy in cervical cancer cells. Prolonged treatment of RSV induced cytosolic translocation of cytochrome c, caspase 3 activation and apoptotic cell death. This apoptotic effect was abrogated by trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane, an inhibitor of cat B and L, but not by pepstatin A, an inhibitor of cat D. As cervical cancer cells express little cat B, we further studied the role of cat L. RSV induced dissipation of the lysosomal membrane permeability (LMP), leakage and increased cytosolic expression and activity of cat L. Inhibition of cat L by small interference RNA (siRNA) protected cells from RSV-induced cytotoxicity. In contrast, inhibition of SCCA 1 by siRNA promoted RSV-induced cytotoxicity. Inhibition of autophagic response by wortmannin (WT) or asparagine (ASP) resulted in decreased early LC3-II formation, reduced LMP, and abolishment of the increase in RSV-induced cell death. In conclusion, we have identified a new cytotoxic mechanism in which the lysosomal enzyme cat L acts as a death signal integrator in cervical cancer cells. Furthermore, SCCA 1 may play an antiapoptotic role through anti-cat L activity.
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“Moreover, CTSL appears to play a key role in the regulation of autophagic adaptation vs. RCD in cells responding to the LMP inducer resveratrol [783, 784].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [783]
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Metadata
- Authors
- Hsu, K.-F., Wu, C.-L., Huang, S.-C., Wu, C.-M., Hsiao, J.-R., Yo, Y.-T., Chen, Y.-H., Shiau, A.-L., & Chou, C.-Y.
- Affiliations
- National Cheng Kung University (TW)
- Chi Mei Medical Center (TW)
- National Cheng Kung University Hospital (TW)
- Corresponding author
- Shiau, Ai-Li
- Chou, Cheng-Yang
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2009-05-16
- Volume
- 5
- Issue
- 4
- Pages
- 451-460
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2113492659
- Cited by
- 155
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 5 · 2020: 15 · 2019: 7 · 2018: 14 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 11 · 2013: 9 · 2012: 12
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- National Cheng Kung University
- National Institute for Basic Biology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- cathepsin L, resveratrol, cervical cancer, apoptosis, SCCA1, lysosomal membrane permeability, LC3-II, cytochrome c release, caspase-3 activation, lysosomal proteases, wortmannin, L-asparaginase, siRNA knockdown
- MeSH terms
- Resveratrol, Autophagy, Cathepsins, Uterine Cervical Neoplasms, Cysteine Endopeptidases, Cytosol, Enzyme Activation, Extracellular Space, Female, Humans, Intracellular Membranes, Iron, Lysosomes, Models, Biological, Permeability, Stilbenes, Apoptosis, Protein Transport, Cytochromes c, Cell Line, Tumor, Cell Proliferation, Caspase 3, Cathepsin L
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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