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Cited by 55Autophagy in Disease and TherapyPhagocytosis and Immune RegulationInvertebrate Immune Response Mechanisms

Eating for good health: Linking autophagy and phagocytosis in host defense

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Sanjuan, Miguel A., Green, Douglas R.·2008·Autophagy
DOI 10.4161/auto.6397PMC PMC2612584
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Abstract

Autophagy is a conserved pathway that sequesters cytoplasmic material and delivers it to lysosomes for degradation. Digestion of portions of the cell interior plays a key role in the recycling of nutrients, remodeling, and disposal of superfluous organelles. Along with its metabolic function, autophagy is an important mechanism for innate immunity against invading bacteria and other pathogens. Multicellular organisms seem to have exploited autophagy to eliminate intracellular pathogens that would otherwise grow in the cytoplasm. Surprisingly, autophagy is involved in the response to extracellular pathogens as well, following their engulfment by conventional phagocytosis. Possible links between these two forms of cellular "eating" represent a new dimension in host defense.

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  • LC3 can be recruited to single-membrane phagosomes in a process termed LC3-associated phagocytosis (LAP).

    “Recently, it has been demonstrated that LC3 can be recruited to other membranes including single-membrane phagosomes, in a process termed LC3-associated phagocytosis (LAP).”

    From LC3-Associated Phagocytosis (LAP): Connections with Host Autophagy (2012) · cites this paper as [17]

    The Intracellular Pathogens Surrender to Autophagy section says LC3 is conjugated directly to the phagosome without forming an autophagosome. Figure 1 contrasts this single-membrane process with double-membrane autophagy. Our copy does not call the process “LC3-associated phagocytosis” or “LAP.” (LLM, conf=0.83)

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Authors
Sanjuan, M. A., & Green, D. R.
Affiliations
St. Jude Children's Research Hospital (US)
ORCID
Green, Douglas R.
Venue
Autophagy
Publisher
Informa UK Limited
Published
2008-06-09
Volume
4
Issue
5
Pages
607-611
ISSN
  • 1554-8627 (ISSN-L)
  • 1554-8635
DOI
10.4161/auto.6397
PMC
PMC2612584
OpenAlex
W2053789332
Cited by
55
References
0
Citations by year
2026: 3 · 2025: 1 · 2023: 3 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 5
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Autophagy (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (P01CA069381)
  • National Institute of General Medical Sciences (R01GM052735)
  • National Institute of Allergy and Infectious Diseases (R01AI044828, R01AI040646, R01AI047891)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords
phagocytosis, host defense, innate immunity, intracellular pathogens, extracellular pathogens, lysosomal degradation, nutrient cycling, pathogen clearance
MeSH terms
Animals, Autophagy, Humans, Immune System, Immunity, Innate, Phagocytosis, Phagosomes

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