The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Notch Signaling in Cancer
Open accessAbstract
Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant transformation, pathophysiologic Notch signals potentially contribute to cancer development in several different ways. Notch signaling was first linked to tumorigenesis through identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL).(1) Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. In this review, we will focus on recent studies linking aberrant Notch signaling with cancer. First, we discuss various mechanisms through which Notch signaling may influence cellular transformation. Then, we critically review literature pertaining to the role of Notch signaling in several cancers, and discuss possible therapeutic targets in the Notch pathway.
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Citations
Cites
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology · doi:10.1038/ni793 · Cited by 478
Cited by
Notch signaling: control of cell communication and cell fate
Lai, E. C. (2004) · Development · doi:10.1242/dev.01074 · Cited by 1,050
Notch1 and Notch2 Have Opposite Effects on Embryonal Brain Tumor Growth
Fan, X., Mikolaenko, I., Elhassan, I., Ni, X., Wang, Y., Ball, D., Brat, D. J., Perry, A., & Eberhart, C. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1446 · Cited by 382
Alam, H., Sehgal, L., Kundu, S. T., Dalal, S. N., & Vaidya, M. M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-08-0703 · Cited by 301
Shafi, O. (2016) · BMC Neurology · doi:10.1186/s12883-016-0765-2 · Cited by 125
Brumby, A., Secombe, J., Horsfield, J., Coombe, M., Amin, N., Coates, D., Saint, R., & Richardson, H. (2004) · Genetics · doi:10.1534/genetics.104.026617 · Cited by 49
Metadata
- Authors
- Allenspach, E. J., Maillard, I., Aster, J. C., & Pear, W. S.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2002-08-13
- Volume
- 1
- Issue
- 5
- Pages
- 466-476
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2004916479
- Cited by
- 344
- References
- 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Allenspach, E. J., Maillard, I., Aster, J. C., & Pear, W. S. (2002). Notch Signaling in Cancer. Cancer Biology & Therapy. https://doi.org/10.4161/cbt.1.5.159
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
