The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mAPK
Open accessAbstract
Curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells. Hence, the aim of the present study was to investigate the anticancer properties of curcumin in cisplatin-resistant human ovarian cancer cells in vitro. The results indicated that curcumin inhibited the proliferation of both cisplatin-resistant (CR) and sensitive (CS) human ovarian cancer cells almost equally. Enhanced superoxide generation was observed in both CR and CS cells treated with curcumin. Curcumin induced G(2)/M phase cell-cycle arrest in CR cells by enhancing the p53 phosphorylation and apoptosis through the activation of caspase-3 followed by PARP degradation. Curcumin also inhibited the phosphorylation of Akt while the phosphorylation of p38 MAPK was enhanced. In summary, our results showed that curcumin inhibits the proliferation of cisplatin-resistant ovarian cancer cells through the induction of superoxide generation, G(2)/M arrest, and apoptosis.
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Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?
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Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment
Chikara, S., Nagaprashantha, L. D., Singhal, J., Horne, D., Awasthi, S., & Singhal, S. S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2017.11.002 · Cited by 559
Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route
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Metadata
- Authors
- Weir, N. M., Selvendiran, K., Kutala, V. K., Tong, L., Vishwanath, S., Rajaram, M., Tridandapani, S., Anant, S., & Kuppusamy, P.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2007-02
- Volume
- 6
- Issue
- 2
- Pages
- 178-184
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2056984342
- Cited by
- 275
- References
- 52
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mAPK. https://app.cochat.ai/papers/10.4161/cbt.6.2.3577
- The paper
- Weir, N. M., Selvendiran, K., Kutala, V. K., Tong, L., Vishwanath, S., Rajaram, M., Tridandapani, S., Anant, S., & Kuppusamy, P. (2007). Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mAPK. Cancer Biology & Therapy. https://doi.org/10.4161/cbt.6.2.3577
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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