The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RNA processing in human mitochondria
Open accessAbstract
Mammalian mitochondrial DNA is transcribed as precursor polycistronic transcripts containing 13 mRNAs, 2 rRNAs, punctuated by 22 tRNAs. The mechanisms involved in the excision of mitochondrial tRNAs from these polycistronic transcripts have remained largely unknown. We have investigated the roles of ELAC2, mitochondrial RNase P proteins 1 and 3, and pentatricopeptide repeat domain protein 1 in the processing of mitochondrial polycistronic transcripts. We used a deep sequencing approach to characterize the 5' and 3' ends of processed mitochondrial transcripts and provide a detailed map of mitochondrial tRNA processing sites affected by these proteins. We show that MRPP1 and MRPP3 process the 5' ends of tRNAs and the 5' unconventional, non tRNA containing site of the CO1 transcript. By contrast, we find that ELAC2 and PTCD1 affect the 3' end processing of tRNAs. Finally, we found that MRPP1 is essential for transcript processing, RNA modification, translation and mitochondrial respiration.
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Cites
PNPASE Regulates RNA Import into Mitochondria
Wang, G., Chen, H.-W., Oktay, Y., Zhang, J., Allen, E. L., Smith, G. M., Fan, K. C., Hong, J. S., French, S. W., McCaffery, J. M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.035 · Cited by 366 · cited 1×
“An additional RNA-containing RNase P has been reported, which may function in mitochondria with an alternative or complementary processing specificity.(12) Recently we have shown that manipulating the expression of another PPR domain protein, pentatricopeptide repeat domain protein 1 (PTCD1), alters the abundance of s…”
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Cited by
Mechanisms and regulation of protein synthesis in mitochondria
Kummer, E., & Ban, N. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00332-2 · Cited by 349
Boczonadi, V., Müller, J. S., Pyle, A., Munkley, J., Dor, T., Quartararo, J., Ferrero, I., Karcagi, V., Giunta, M., Polvikoski, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5287 · Cited by 149
LRPPRC-mediated folding of the mitochondrial transcriptome
Siira, S. J., Spåhr, H., Shearwood, A.-M. J., Ruzzenente, B., Larsson, N.-G., Rackham, O., & Filipovska, A. (2017) · Nature Communications · doi:10.1038/s41467-017-01221-z · Cited by 123
Self-citationThe post-transcriptional life of mammalian mitochondrial RNA
Rorbach, J., & Minczuk, M. (2012) · Biochemical Journal · doi:10.1042/bj20112208 · Cited by 118
Lopez Sanchez, M. I. G., Waugh, H. S., Tsatsanis, A., Wong, B. X., Crowston, J. G., Duce, J. A., & Trounce, I. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-10233-0 · Cited by 45
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Metadata
- Authors
- Lopez Sanchez, M. I. G., Mercer, T. R., Davies, S. M. K., Shearwood, A.-M. J., Nygård, K. K. A., Richman, T. R., Mattick, J. S., Rackham, O., & Filipovska, A.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 10
- Issue
- 17
- Pages
- 2904-2916
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1969625755
- Cited by
- 238
- References
- 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lopez Sanchez, M. I. G., Mercer, T. R., Davies, S. M. K., Shearwood, A.-M. J., Nygård, K. K. A., Richman, T. R., Mattick, J. S., Rackham, O., & Filipovska, A. (2011). RNA processing in human mitochondria. Cell Cycle. https://doi.org/10.4161/cc.10.17.17060
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