Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
Open accessAbstract
Aging is unmistakable and undeniable in mammals. Interestingly, mice develop cataracts, muscle atrophy, osteoporosis, obesity, diabetes and cognitive deficits after just 2-3 postnatal years, while it takes seven or more decades for the same age-specific phenotypes to develop in humans. Thus, chronological age corresponds differently with biological age in metazoan species and although many theories exist, we do not understand what controls the rate of mammalian aging. One interesting idea is that species-specific rate of aging represents a ratio of tissue attrition to tissue regeneration. Furthermore, current findings suggest that the age-imposed biochemical changes in the niches of tissue stem cells inhibit performance of this regenerative pool, which leads to the decline of tissue maintenance and repair. If true, slowing down stem cell and niche aging, thereby promoting tissue regeneration, could slow down the process of tissue and organismal aging. In this regard, recent studies of heterochronic parabiosis provide important clues as to the mechanisms of stem cell aging and suggest novel strategies for enhancing tissue repair in the old. Here we review current literature on the relationship between the vigor of tissue stem cells and the process of aging, with an emphasis on the rejuvenation of old tissues by the extrinsic modifications of stem cell niches.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exposure to a younger systemic environment alleviated age-associated tissue dysfunctions in ageing telomerase-deficient mice.
“Exposure to a younger systemic environment was also shown to relieve age-associated tissue dysfunctions in ageing telomerase-deficient mice269.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [269]
The Heterochronic Parabiosis section says that work in telomerase-knockout mice suggests age-related changes in the systemic environment might contribute to hematopoietic stem-cell aging. The review also reports improved tissue maintenance and repair from young systemic factors in old mammals (Is Aging of Other Adult Tissues a Stem Cell Paradigm?). It does not say that exposure to a younger environment relieved tissue dysfunction in the telomerase-deficient mice specifically; page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 61 · Cited by 239
Research works printed but not linked: 1
- [61]61. Bert P. Expériences et Considérations Sur la Greffe Animale. Journal del al Anatomie et de la Physiologie 1864; 1:69-87.
- Authors
- Conboy, I. M., & Rando, T. A.
- Affiliations
- QB3 (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Conboy, Irina M.
- Rando, Thomas A.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2012-06-15
- Volume
- 11
- Issue
- 12
- Pages
- 2260-2267
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC3383588
- OpenAlex
- W1978269248
- Cited by
- 239
- References
- 61
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 6 · 2023: 17 · 2022: 14 · 2021: 17 · 2020: 25 · 2019: 20 · 2018: 19 · 2017: 16 · 2016: 11 · 2015: 22 · 2014: 20 · 2013: 20 · 2012: 5
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs (P01 AG036695)
- W. M. Keck Foundation
- Glenn Foundation for Medical Research (P01 AG036695, R01 AR062185)
- Fondation pour la Recherche Médicale
- National Institutes of Health (DP1OD000392, AG023806, OD000392, AG036695)
- National Institute on Aging (R37AG023806, R01 AG 0277252, R01AG023806, P01AG036695)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR062185, R01AR056849)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- heterochronic parabiosis, aging, stem cells, stem cell niche, tissue regeneration, biological age, tissue repair
- MeSH terms
- Animals, Humans, Parabiosis, Regeneration, Rejuvenation, Stem Cells, Signal Transduction, Transforming Growth Factor beta, Cellular Senescence, Muscle, Skeletal, Wnt Proteins, Stem Cell Niche
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
