Glutaminolysis feeds mTORC1
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Glutamine is an important amino acid from a metabolic point of view. As an amino acid and a precursor for other amino acids, it sustains protein synthesis. It is also required for production of nuc...
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α-KG induces mTORC1 activation by enhancing GTP loading of RagB in a PHD-dependent manner, promoting cell growth.
“α-KG induces mTORC1 activation by enhancing GTP loading of the RagB protein in a PHD-dependent manner, thus promoting cell growth160,161.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [160]
Glutaminolysis increases α-KG, resulting in GTP loading of RagB and lysosomal translocation of mTORC1 in human cancer cell lines.
“According to another study, glutaminolysis increases the level of α-KG production, resulting in GTP loading of RagB and lysosomal translocation of the mTORC1 complex in human cancer cell lines160.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [160]
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References 10 · Cited by 77
- Authors
- Durán, R. V., & Hall, M. N.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Hall, Michael N.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2012-11-15
- Volume
- 11
- Issue
- 22
- Pages
- 4107-4108
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC3524199
- OpenAlex
- W2060450593
- Cited by
- 77
- References
- 10
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 10 · 2016: 3 · 2015: 8 · 2014: 7 · 2013: 7
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Cell Cycle (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- edoc (University of Basel)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- glutaminolysis, mTORC1, glutamine metabolism, amino acid metabolism, protein synthesis, nucleotide synthesis, nutrient signaling
- MeSH terms
- Mechanistic Target of Rapamycin Complex 1, Animals, Autophagy, Glutamine, Glutarates, Humans, Isocitrate Dehydrogenase, Ketoglutaric Acids, Mutation, Multiprotein Complexes, Mice, Gene Knock-In Techniques, TOR Serine-Threonine Kinases
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