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Cited by 90DNA Repair MechanismsDNA and Nucleic Acid ChemistryFungal and yeast genetics research

9-1-1 Complex Involvement in DNA Repair: Evidence that DNA Damage Detection Machinery Participates in DNA Repair

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Helt, Christopher E., Wang, Wensheng, Keng, Peter C., Bambara, Robert A.·2005·Cell Cycle
DOI 10.4161/cc.4.4.1598
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Abstract

The toroidal Rad9-Rad1-Hus1 checkpoint complex (9-1-1) is structurally similar to the proliferating cell nuclear antigen (PCNA), which serves as a sliding clamp platform for DNA replication and repair. 9-1-1 has been characterized as a sensor of DNA damage that functions in concert with the checkpoint control proteins ATM and ATR. However, recent data suggest that the 9-1-1 complex and its individual Rad9 component serve different and multiple functions in cells by sensing DNA damage, stimulating apoptosis, and regulating gene transcription. Recently it was reported that 9-1-1 interacts with and/or stimulates components of the base excision repair (BER) pathway including the S. pombe MutY homolog (MYH), human polymerase beta (Polbeta), and flap endonuclease 1 (FEN1). Furthermore, preliminary results indicate a stimulation of DNA ligase I. In this review, the likely direct participation of 9-1-1 in DNA repair is discussed.

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Cited by 90

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Authors
Helt, C. E., Wang, W., Keng, P. C., & Bambara, R. A.
Affiliations
University of Rochester Medicine (US)
ORCID
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2005-01-28
Volume
4
Issue
4
Pages
529-532
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
DOI
10.4161/cc.4.4.1598
OpenAlex
W2092469788
Cited by
90
References
0
Citations by year
2026: 4 · 2025: 2 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
0.57
Type
journal article
Language
en
Open access
Locations
  • Cell Cycle (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (T32CA009363, CA-09363)
  • National Institute of General Medical Sciences (GM02444)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Rad9, DNA damage detection, DNA repair, base excision repair, MUTYH, DNA polymerase beta, FEN1, DNA ligase I, ATM, ATR, DNA damage checkpoint, apoptosis, transcriptional regulation
MeSH terms
Animals, Cell Cycle, DNA Damage, DNA Repair, Exonucleases, Gene Expression Regulation, Humans, Protein Binding, Schizosaccharomyces, Transcription, Genetic, Apoptosis, Cell Cycle Proteins, Proliferating Cell Nuclear Antigen, DNA Polymerase beta, Schizosaccharomyces pombe Proteins, Flap Endonucleases, DNA Glycosylases

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